Cancer is a big problem in the history of human medicine, and there is no way to completely cure it at present. In the face of cancer with extremely high mortality, life is fragile. No matter whether it is poor or rich, famous or unknown, we often see the news that celebrities have died of cancer, and we can’t help sighing, but there are also some wonderful experiences of anti-cancer success!　 Many cancer patients often lose confidence in life after learning that they have cancer, do not actively treat them, or even resist treatment, and feel that treatment is unnecessary, and treatment is a waste of money. In fact, this idea is not correct. Don’t give up until the last moment. Even if cancer has not been completely overcome, after scientific and reasonable treatment with many patients, life can be continued, and even clinical cure or long-term survival with tumors can be achieved! Nowadays, there are many treatments for cancer. If it is found as early as possible and treated actively, one third of cancer can be cured. Medical "cure" is different from what people usually understand. The clinical cure here refers to the disappearance of symptoms and signs after treatment, and the tumor can not be found after image review for more than 5 years.

Today, Xiaobian, a cancer-free home, will share the stories of four celebrities who have succeeded in fighting cancer, and see how they fight cancer. I hope to give some reference and motivation to all cancer friends!

Kai-Fu Lee: From the late stage of cancer to the disappearance of tumor, chemotherapy+targeted therapy against advanced lymphoma.

　 On September 5th, 2013, 52-year-old Kai-fu Lee, the founder of Innovation Factory, announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from. 　

Lymphoma, also known as lymphoma, occurs in the lymphatic system and is one of the malignant diseases of the blood system. In fact, we are no strangers. Besides Kai-Fu Lee, celebrities such as Luo Jing, Asan and Cindy Lee have also suffered from lymphoma. The incidence of lymphoma is actually not too high in malignant tumors, which is about 5/100,000. It can occur at any age, but it is mainly in middle-aged people aged 30-50. The malignant degree of different types of lymphoma varies greatly, which can be roughly divided into: inertia, aggression and high aggression. Inertial lymphoma is similar to chronic diseases, while high aggression is like a "death warrant"! There are many types of lymphoma, but as long as we know, lymphoma can be divided into Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL), the latter accounting for about 90%, and diffuse large B-cell lymphoma is the main type (40%~50%). When you know that you have stage 4 or systemic metastasis, it doesn’t mean that your condition is very serious and there is no cure. Don’t give up treatment easily. The treatment of lymphoma is mainly systemic chemotherapy and radiotherapy. Li Kaifu’s treatment plan is that bendamustine (bendamustine) is combined with rituximab (rituximab, trade name: rituximab). Different from traditional chemotherapy drugs, rituximab is called "an artifact to accurately combat lymphoma". It is an anti-CD20 monoclonal antibody against malignant B lymphocytes, with good effect and little side effects, and it is a milestone in the treatment of lymphoma. 　

Since rituximab was listed in the United States in 1999, the 5-year survival rate of patients with diffuse large B-cell lymphoma has increased to 50%. Rituximab used to be a self-funded drug, which was expensive. Now it has been included in the scope of medical insurance reimbursement, which has enabled many cancer friends to enjoy the fruits of modern medical progress.　　

In addition, Kai-Fu Lee also tried many kinds.Natural therapyIn order to finally defeat cancer.

Keeping a good sleep is the most important thing. Staying up late for a long time may reduce the body’s immunity, and his lymphoma is a common cancer in the immune system. Therefore, after suffering from cancer, he made a schedule to protect his immunity. It is necessary to keep your mouth shut when disaster comes from your mouth. It is particularly important for cancer patients to keep their mouths shut, and maintaining good eating habits can better fight cancer. Kai-fu Lee suggested that everyone should eat more grains, beans, fruits and vegetables, and take a balanced intake. 3. Take your legs apart and exercise properly to inhibit cancer cells. Many studies have confirmed that exercise is beneficial to the rehabilitation of cancer patients and can reduce the risk of cancer recurrence after operation. However, it should be reminded that not all exercise is suitable for cancer patients, and it is suggested to use the principle of "not feeling tired". 4. Good attitude, get twice the result with half the effort When fighting cancer, it is very important to keep a good attitude, which has a great influence on cancer treatment.

Pancreatic cancer: steinman "tried medicine by himself", and the dendritic cell vaccine made him live for four and a half years!

　 Speaking of vaccines, everyone is actually familiar with them, except for the common hepatitis B vaccine and influenza vaccine, and the Covid-19 vaccine that we have vaccinated up to now. In fact, cancer vaccine is also a form of immunotherapy, which can prevent cancer from developing or kill existing tumors by stimulating or restoring the human immune system. In the 21st century, the high incidence of cancer has attracted the attention of the global medical community. As a prominent tumor vaccine, dendritic cell vaccine has been a research hotspot in this field. When it comes to dendritic cell vaccine, we have to mention a legendary figure-ralph steinman, winner of the 2011 Nobel Prize in Physiology or Medicine. 　　

ralph marvin steinman After the diagnosis of pancreatic cancer in 2007, steinman actively tried a therapeutic vaccine (DC vaccine) based on dendritic cells. With the help of this "cellular immunotherapy", his life was extended from the expected months to four and a half years.　 There is a rule in the Nobel Prize that they never give this prize to people who have passed away. However, ralph steinman broke this rule because he passed away quietly three days before receiving the call for winning the prize. Therefore, Staman is also called the most regrettable Nobel Prize winner.

　 0one　　Suffering from pancreatic cancer with a mortality rate of 95%, he devoted himself to the research of DC vaccine.

In 1973, steinman discovered dendritic cells in the spleen of mice, and put forward the concept of dendritic cells. In 2011, steinman shared the Nobel Prize in Physiology or Medicine with Jules Hoffman and Bruce Beutler for "discovering dendritic cells and their role in the acquired immune system".

Pancreatic cancer, which claimed steinman’s life, is one of the malignant tumors with the highest mortality rate at present. The mortality rate of this disease can reach 95% clinically, and it is very rare for patients who can survive for 5 years after being diagnosed with this disease (< 5%). There is no approved cancer vaccine for pancreatic cancer, and the prognosis is very poor. The survival time of advanced patients is weeks or months. The disease is usually treated with the cytotoxic drug gemcitabine. However, this treatment seems to be mainly used for palliative treatment of advanced pancreatic cancer, which can improve the quality of life and prolong the median survival time of 5 weeks. Most patients will soon develop resistance to this drug. Therefore, the indomitable Professor steinman tried to use dendritic cell vaccine to treat his pancreatic cancer. Dendritic cells are the main antigen presenting cells (APC) in the immune system. They process antigenic substances (for example, from invading bacteria and viruses, and from cancer cells) and present antigens on their surfaces to other types of immune cells, especially T cells. This leads to antigen-specific activation of T cells. Therefore, dendritic cells act as the main link between innate immune system and adaptive immune system.　

02　　After eight treatments, dendritic cell vaccine made him live for four and a half years!

　 Professor steinman tried eight experimental therapies, one at a time. For each of these treatments, he and his colleagues submitted a single-patient use agreement to the FDA and obtained the approval of the agency. In these treatments, there are three kinds of cancer vaccines, and steinman finally used the dendritic cell vaccine from his own tumor instead of the cell line. Patients with advanced pancreatic cancer usually have poor prognosis. The median survival time of locally advanced and metastatic pancreatic cancer (advanced pancreatic cancer accounts for more than 80% of individuals diagnosed with the disease) is about 10 months and 6 months respectively. For all stages of pancreatic cancer, the 1-year and 5-year relative survival rates were 25% and 6%, respectively. However, Dr. steinman’s life span has been extended from several months to four and a half years! Since then, the medical community has launched a craze for the research and development of dendritic cell vaccines, which has become a kind of immunotherapy with more research and development achievements in recent years. At present, the dendritic cell vaccines approved by the FDA and many clinical trials entering the third phase are worth looking forward to. Since 2010, exceptThe FDA approved the first dendritic cell vaccine Provenge(sipuleucel-T) for the treatment of refractory prostate cancer. Dendritic cell vaccine has achieved good results in all kinds of cancer. Such as brain tumor-DC VAX-L vaccine, melanoma-—TLPLDC vaccine, renal cancer-—ilixadencel vaccine, newly diagnosed glioblastoma-AV-GBM-1 vaccine, lung cancer-CCL 21-dendritic vaccine, breast cancer -Her2 pulsed dendritic cell vaccine, etc.Xiaobian will not go into details here.

Nasopharyngeal Carcinoma: After 33 proton treatments, Li Zongwei successfully returned to badminton.

　 As the uncrowned king of badminton in the world, Li Zongwei, a famous Malaysian badminton player, has a brilliant career, with three runners-up in the Olympic Games, four runners-up in the World Championships, one runner-up in the soup cup and one silver medal in the men’s singles in the Asian Games. However, on July 25, 2018, he met another more powerful opponent-nasopharyngeal cancer. According to Malaysian media reports, Li Zongwei suddenly announced his withdrawal from the World Badminton Championships and the Asian Games badminton competition, and was later confirmed to have early nasopharyngeal carcinoma in September. However, Li Zongwei was not defeated by the disease. After 33 proton treatments of 25 minutes each time for more than two months, the doctor said that all the cancer cells in his body had been eliminated. In October of the same year, after he announced the success of anti-cancer, he said that he would return to badminton in December. Perhaps Li Zongwei is not a "winner" in badminton. Although he has won numerous titles, he has never won a world championship, including a slightly dismal record against Lin Dan. This time, however, in the face of this "competition" with the same disease, he finally won. This win will be the greatest capital of his life. In terms of treatment, it is difficult to perform radical surgery because of the special location and unclear boundary of nasopharyngeal carcinoma, the deep and narrow nasopharyngeal cavity, and many important blood vessels, cranial nerves and lymphoid tissues around it. But nasopharyngeal carcinoma is sensitive to radiotherapy, Therefore, radiotherapy is the main treatment for nasopharyngeal carcinoma, especially proton therapy. As the "king" of "precision radiotherapy", it can not only show its talents, but also effectively prevent the side effects of radiotherapy.

Proton therapy is a "qualitative leap" in tumor radiation!

　 Proton therapy is to accelerate the nucleus of hydrogen atom (i.e. proton) which has lost electrons to about 70% of the speed of light by using cyclotron or synchrotron. After being accelerated by the accelerator, protons with positive charges become very penetrating ionizing radiation, which enters the human body at a very high speed, is guided by special-shaped equipment, and finally reaches the targeted tumor site. Because of its high speed, the chance of interaction with normal tissues or cells in the body is extremely low. When it reaches a specific part of the tumor, the speed suddenly decreases and stops, and the maximum energy is released, resulting in a "Bragg peak", which can kill cancer cells without causing damage to surrounding tissues and organs.

When tumors are directly adjacent to important organs or structures, such as spinal cord, optic nerve and heart, proton therapy can still effectively treat tumors while protecting the functions of these important organs or structures, which is impossible in conventional radiation therapy.

The high radiation dose is concentrated in the tumor site, and there is no/little dose in the surrounding normal tissues.

Legend: The radiation of Intensity Modulated Proton Therapy (IMPT) is mainly concentrated around the focus of nasopharyngeal carcinoma, with little or no influence on the surrounding normal tissues, while the radiation area of Intensity Modulated Radiotherapy (IMRT) is large, covering the focus and surrounding normal tissues.

Melanoma: "cured" after 4 months, immunotherapy made Carter the "longest-lived president"

　 In August 2015, former US President Carter was diagnosed with malignant melanoma, and liver metastasis and brain metastasis have occurred, so he is an out-and-out terminal patient. But just four months later, at an event in December, 91-year-old Carter announced that he had just confirmed after a general examination that the lesions in his body had disappeared. 　

It is understood that Carter used comprehensive therapy. First, the visible tumor was surgically removed, then the intracranial tumor was treated by radiotherapy, and finally the PD-1 drug Keytruda of Merck was used. After the brain cancer cells disappeared, Carter said that he would continue to use Keytruda for treatment. This incident made immunotherapy popular all over the world overnight. PD-1/PD-L1 and CTLA-4 pathways are crucial to the immune system’s ability to control cancer growth. These pathways are often called immune checkpoints. Many cancers will use these ways to escape the immune system. Specific antibodies to immune checkpoint inhibitors can block these pathways to deal with cancer. Once the immune system can find and deal with cancer, it can stop or slow down the development of cancer. Having said that, I have to mention the biggest difference between immunotherapy and traditional treatment, that is The trailing effect of immunotherapy, that is, patients who benefit from immunotherapy can continuously obtain stable results and bring long-term survival.

This article is original for a cancer-free home, and it needs authorization to reprint.

On October 29th, China Meteorological Bureau held a press conference in November 2024. At the meeting, Xiong Shaoyuan, member of the party group and deputy director of China Meteorological Bureau, introduced the main progress in the modernization of meteorological social services.

Xiong Shaoyuan, member of the Party Group and Deputy Director of China Meteorological Bureau, Zhang Aoguang Photography

In terms of ensuring safety, Xiong Shaoyuan said that China Meteorological Bureau adhered to the principle of putting people first and life first, actively integrated into the national emergency framework, and effectively built the first line of defense for meteorological disaster prevention and mitigation.

According to reports, in terms of emergency linkage mechanism with meteorological disaster warning as the guide, the progressive meteorological service mechanism has achieved national coverage, and a high-level early warning "calling" system has been established and improved. Since 2023, the cumulative number of party and government leaders at all levels and flood control has reached 580,000.

In terms of meteorological disaster risk early warning capability, the first national comprehensive risk survey of natural disasters was completed in 10 categories, and 45 meteorological disaster risk products were released daily. The accuracy of rainstorm warning signal has been improved to 93%, the early warning time of severe convective weather has reached 43 minutes, and the meteorological warning information can be delivered to the public in 3 to 8 minutes, with a coverage rate of 98.8%. In the past five years, the number of deaths caused by meteorological disasters has decreased by an average of 48.5% compared with that between 2014 and 2018, and the proportion of economic losses to GDP has decreased by an average of 0.15%.

In terms of weather modification ability, in the past five years, 5,547 aircraft operations and more than 227,000 ground operations have been organized, with an average annual increase of over 38 billion tons of precipitation, an area affected by artificial precipitation (snow) reaching 5 million square kilometers, and an area protected by artificial hail suppression reaching 600,000 square kilometers.

In terms of high-quality and efficient development, Xiong Shaoyuan said that China Meteorological Bureau adheres to the "big service concept" and meteorological services cover more than 70 industries in the national economy. Focusing on food security, the Ministry of Agriculture and Rural Affairs jointly issued 12 types of agro-meteorological disaster risk warnings. This year, according to the dry-hot wind warning, various localities adopted measures such as "one spray and three defenses" to help winter wheat reduce disasters and increase income by about 3 billion Jin. Focusing on ensuring smooth traffic, the Ministry of Public Security and the Ministry of Transport jointly created a new mode of "one road, three parties" linkage control. The number of traffic accidents caused by bad weather decreased by 50% year-on-year and the operational efficiency increased by 42%. Focusing on helping the development of new quality productivity, 59 meteorological high-value data products were listed on the data exchange. Explore the "meteorology × finance" service, initially build the meteorological service for risk reduction before the disaster, release the first batch of 69 financial meteorological indexes, and establish the financial meteorological index service platform.

(Original title: China Meteorological Bureau: The accuracy of rainstorm warning signal has increased to 93%, and meteorological warning information can be delivered to the public in 3 to 8 minutes)

(Source: Red Star News Author: Hu Yiwen Editor: Guo Manru)

　　CCTV Finance reported on July 20 that in recent days, the phenomenon of vaccine shortage has appeared frequently. Just two days ago, the Shenzhen Municipal Center for Disease Control and Prevention said that the first-class vaccine gap in Shenzhen reached 175,000, and in Guangxi, many parents who vaccinated their children also suffered from vaccine shortage.

　　CCTV Finance "Economic Information Network" column video (01:35)

　　Ms. Long, a citizen of Nanning, Guangxi:DTP has not been vaccinated since May 8th, and now it is more than July 10th. There is no vaccine yet. Originally, four shots were given, but now only two shots have been given.

　　Ms. Long has an eight-month-old child. She should have been vaccinated with the third DTP vaccine in May, but she was delayed for two months, which made her a little worried. There are many parents who have the same experience as Ms. Long.

　　Citizens of Nanning, Guangxi:DTP is free and out of stock.

　　Citizens of Nanning, Guangxi: at my own expense. We waited too long, and the doctor said we didn’t know when it would be available, so we had to call first.

　　According to Guangxi Center for Disease Control and Prevention, there are five kinds of vaccines, namely, leprosy vaccine, measles vaccine, DTP vaccine, hepatitis A vaccine and Japanese encephalitis vaccine, which are currently lacking in Guangxi. Among them, the supply rate of leprosy vaccine with the biggest gap is less than 20%.

　　(1) Leprosy vaccine. Since January 1, 2019, the supply rate in Guangxi has been 19%, and the supply has been insufficient since July 2018.

　　(2) DTP vaccine. Since January 1, 2019, the supply rate in Guangxi has been 32%, and the supply has been insufficient since July 2018.

　　(3) measles vaccine. Since January 1, 2019, the supply rate in Guangxi has been 59%, and the supply has been insufficient since January 2019.

　　(4) Hepatitis A vaccine. Since January 1, 2019, the supply rate in Guangxi has been 72%, and the supply has been insufficient since January 2019.

　　(5) Japanese encephalitis vaccine. Since January 1, 2019, the supply rate in Guangxi has been 60%, and the supply has been insufficient since January 2019.

　　The person in charge of the Guangxi Center for Disease Control and Prevention said that the above-mentioned vaccine shortage is nationwide, mainly because the production capacity of production enterprises is insufficient, and there is no sign of improvement in supply in a short time. These shortages of class I free vaccines can be replaced by self-funded class II vaccines.

　　Zhong Ge, Director of Institute of Immunization Planning, Guangxi Center for Disease Control and Prevention:Newborns have received one or two injections of the first-class vaccine, but if they have not completed the immunization procedure, they can use the second-class vaccine instead of the later injections, which can also achieve the effect of immune protection.

　　(The original title is "Some vaccines are out of stock nationwide! What about the children during the shortage period? The CDC responded &rarr; 》）

　　Huang Qiang, male, Han nationality, born in April 1963 in Dongyang, Zhejiang Province, joined the work in July 1983 and joined the Communist Party of China (CPC) in June 1985. He graduated from the School of Management of Northwestern Polytechnical University with a master’s degree, a doctor of engineering and a researcher-level senior engineer.

　　1979.09&mdash; 1983.07 majoring in aeronautical electrical engineering, Department of Aviation Automatic Control, Northwestern Polytechnical University

　　1983.07&mdash; 1987.09 Designer, Room 14, No.603 Institute of Aviation Industry

　　1987.09&mdash; In March 1990, he studied aviation electrical engineering in the Department of Aviation Automatic Control of Northwestern Polytechnical University and obtained a master’s degree in engineering.

　　1990.03&mdash; 1992.12 Engineer, deputy head and deputy director of the ad hoc system design room of the Engineering Development Department of Xi ‘an Aircraft Industry Company, Ministry of Aerospace.

　　1992.12&mdash; 1994.10 Director of the Ad Hoc System Design Office of the Ministry of Aerospace and Aviation Industry Corporation No.603 (during this period: 1994.03&mdash; In August 1994, China Aviation Technology Import and Export Shenzhen Company took a post exercise)

　　1994.10&mdash; April 2000 Assistant Director and Deputy Director of No.603 Institute of China Aviation Industry Corporation and General Manager and Executive Deputy Director of Science and Technology Industry Corporation (during this period: February 1998.02&mdash; 1998.06 Studying in English Training Class of Xi ‘an Foreign Languages Institute; 1999.03&mdash; 1999.07 Central Party School’s prefectural-level cadre training class)

　　2000.04&mdash; 2003.04 Director of No.603 Institute of China Aviation Industry First Group Corporation

　　2003.04&mdash; 2003.06 Head of the Preparatory Team of the First Aircraft Design and Research Institute of China Aviation Industry Corporation I.

　　2003.06&mdash; 2005.06 Dean, Deputy Secretary of the Party Committee and Director of Shanghai Aircraft Design Institute of China Aviation Industry Corporation I.

　　2005.06&mdash; 2006.01 Dean and Party Secretary of the First Aircraft Design and Research Institute of China Aviation Industry Corporation I and Director and Party Secretary of Shanghai Aircraft Design and Research Institute.

　　2006.01&mdash; 2008.06 Secretary-General of the Commission of Science, Technology and Industry for National Defense (2003.09&mdash; In June 2006, the School of Management of Northwestern Polytechnical University studied as an in-service postgraduate majoring in management science and engineering, and obtained a doctorate in engineering; 2007.03&mdash; 2008.01 Central Party School one-year training course for young and middle-aged cadres)

　　2008.06&mdash; 2014.01 Deputy Director and Member of the Party Group of the State Bureau of Science, Technology and Industry for National Defense

　　2014.01&mdash; 2017.03 Vice Governor of Gansu Province and Member of the Party Group of the Provincial Government

　　2017.03&mdash; 2018.05 Standing Committee of Gansu Provincial Party Committee, Executive Vice Governor and Deputy Secretary of the Party Group of the Provincial Government

　　2018.05&mdash; 2018.06 Standing Committee of Henan Provincial Committee

　　2018.06&mdash; 2020.11 Member of the Standing Committee of Henan Provincial Party Committee, Executive Vice Governor and Deputy Secretary of the Party Group of the Provincial Government

　　2020.11&mdash; 2020.12 Deputy Secretary of Sichuan Provincial Committee

　　2020.12&mdash; 2021.02 Deputy Secretary of Sichuan Provincial Party Committee, Vice Governor, Acting Governor and Party Secretary of the provincial government.

　　2021.02&mdash; Deputy Secretary of Sichuan Provincial Party Committee, Governor of Provincial Government and Party Secretary

　　Deputies to the 13th National People’s Congress and the 13th Provincial People’s Congress.

　　(Resume source: Sichuan Provincial People’s Government Network)

　　Text/Yangcheng Evening News reporter Zhang Hua correspondent Wu Yuantuan Xu Jianying

　　Why do Chinese medicine practitioners who can keep in good health always make you eat less cold things? Yan Fang, director of the Classic Department of Traditional Chinese Medicine of Guangdong Provincial Hospital of Traditional Chinese Medicine, believes that if we want to be healthy, we must first protect our own yang, because the warmth of the yang makes our body move normally. The biggest harm of cold things lies in the loss of human yang, which leads to the weakening of human function. After the weakening of human visceral function, it is easy to cause stagnation of qi and blood stasis. Many of our diseases come from these bad habits that damage yang.

　　Habit 1 Eat a lot of fruit every day.

　　Fruit is rich in vitamins and dietary fiber, which is good for skin and body. So many women eat a lot of fruit every day, eat watermelon and cut it in half, and dig it with a spoon; Eating a bunch of grapes is like eating melon seeds.

　　Yan Fang, director of the Classic Department of Traditional Chinese Medicine of Guangdong Provincial Hospital of Traditional Chinese Medicine, believes that healthy people should eat 250-400g of fruit every day. Western medicine pays attention to the ingredients of fruit, such as "rich in vitamins", but Chinese medicine pays attention to its properties. However, we often ignore the cold or wet weight of fruits, and the storage and transportation are mostly refrigerated. In addition, our Lingnan area has the characteristics of less mountains and more water, and more cold in the middle soil.

　　Modern people, however, are generally cold because of their love of cold drinks, excessive stress and fatigue, abuse of antibiotics, frequent air conditioning and many other factors. This kind of physique, especially for cold and cold fruits, should be cautious and not eat more. Otherwise, excessive cold and dampness will hurt the spleen and stomach, leading to loss of appetite, loose stool, fear of cold and even eczema.

　　Yan Fang suggested that people who are cold and wet should not eat too much fruit. The ancients paid great attention to this point. They didn’t eat fruit on an empty stomach, the infirm didn’t eat fruit, and children and the elderly didn’t dare to give too much fruit to eat. For patients with deficiency cold and particularly greedy mouth, Yan Fang suggested that when eating fruit, a small amount of boiled water should be used for soaking or boiling, which can slightly reduce the coldness. Knowing your physique, choosing the fruit that suits you and tasting it in moderation are the "health tips" for eating fruit.

　　Habit 2 Drink herbal tea at every turn

　　There are few mountains and low terrain in Lingnan area, which shows that "rustic" is thin. The spleen and stomach belong to the soil, which will inevitably affect the function of the spleen and stomach. In addition, the climate here is hot and humid, and everyone thinks that it is necessary to remove more dampness and heat. Herbal tea can clear fire and quench thirst, and it tastes good. There are herbal tea shops all over the street, and the sales are also good.

　　However, eating too much herbal tea that can clear away heat, detoxify and eliminate dampness will further damage the spleen and stomach. The soil is thin and "the soil does not contain fire", so it is naturally easy to "fire" as a disaster!

　　Yan Fang said that repeated fires are mostly caused by deficiency fire, such as dry mouth and bitter taste, red eyes, oral ulcers, swollen gums, sore throat, nosebleeds, dry stools and so on. At the same time, it is accompanied by symptoms such as dull tongue color, pale lips, thin white or slightly greasy tongue coating, light urine color and smell, dry mouth and no desire to drink more, five upset and hot (hands, feet and heart, collectively called five hearts), insomnia and irritability, so the real cure for fire is to regulate the spleen and stomach. If the "rustic" is thick, it will naturally be difficult to get angry!

　　It is not necessary to put out the fire at the sight of the fire, but to get angry and reduce the fire. Drinking too much herbal tea will hurt Zhongyang, and the health will be damaged the day after tomorrow, causing endless harm. The correct way is that herbal tea should be moderate and lead to fire.

　　Habit 3: I have no time during the day and exercise at night.

　　The pace of work and life in the city is fast, and I really don’t have time to exercise during the day. After work, the night is clean, the weather is cool, running and playing ball games, and I feel very sour and refreshing. Plus, there is another reason to eat supper after exercise. Therefore, many people have no time during the day and are used to doing sports at night.

　　Yan Fang believes that improper exercise is better than no exercise. Night exercise calls the human body’s yang, which is contrary to the natural law of "doing at sunrise and resting at sunset", and even affects sleep and rest at night. In addition, supper will hurt the spleen and stomach.

　　Therefore, Yan Fang does not advocate night exercise, and it is the way to keep fit at sunset.

　　Habit 4 Stay up late and make up during the day.

　　At present, young people are under great work pressure and have many recreational activities. Many people are willing to overdraw their physical strength and consume their blood excessively. For example, they always like to stay up late. Others think that if you stay awake at night, you can make up your sleep time the next day.

　　In fact, staying up late is the most harmful to qi and blood. Therefore, people who stay up late usually look haggard and tend to get old. Chinese medicine believes that what is consumed during the day is the yang of the body, and sleeping at night can make the yang get full rest and nourishment. Staying up late for a long time will disturb the balance of yin and yang, qi and blood in the body. Various organs of the body may have different symptoms.

　　Yan Fang believes that the Tao is to preserve one’s health naturally, to do it at sunrise, to rest at sunset, and to stay up late at night is to call the sun be the spirit. Sleeping during the day is to block the yang, and you are not staying up at night, but living.

　　Habit 5 wash your nose with cold water every day

　　Patients with "allergic rhinitis" are very common, and most of them are allergic and have certain heredity. External stimuli, including cold air, pollen, indoor dust, mites, molds, animal hair, dander and poultry feathers, can all lead to nasal itching, continuous sneezing and a lot of clear water-like serous nasal secretions. Each attack lasts for more than one hour and often recurs.

　　Many people are used to washing their noses, thinking that it can clean the bacteria in the nasal cavity, enhance the resistance of the nasal cavity, strengthen the ventilation and drainage of the sinuses, and promote local blood circulation.

　　However, Yan Fang believes that this will consume the body’s yang, reduce the body’s resistance, take the initiative to induce cold pathogens to invade, and lead to recurrent rhinitis.

　　Experts say that washing the nose with cold water does not cure the symptoms, especially cold water washing the nose adds cold to the cold, which encourages cold pathogens to hide in the house, which is not beneficial but harmful. (Watchmaking/Du Hui)

　　People’s Daily Online, Beijing, May 13 (Yang Xi) Recently, the release of the main data of the seventh national census has aroused great concern from all walks of life. Some netizens found that the trend reflected by the census data published this time is inconsistent with that published in non-census years, so they raised some questions about individual data.

　　In this regard, the National Bureau of Statistics answered the above questions and related questions of population statistics.

　　How to count and publish population data?

　　At present, China’s demographic survey mainly has three ways:

　　The first is the national census, which is conducted once every ten years in the year when the mantissa meets "0", and the census data is published in China Census Data.

　　The second is the national 1% population sampling survey, which was conducted in the year when the mantissa met "5", and the survey data was published in the National 1% Population Sampling Survey Data.

　　Third, the national sample survey of population changes, the sample size accounts for about 1&permil of the total population; In addition to the census year and the sampling year of 1% population survey, it is conducted once a year, and the survey data are published in the Statistical Yearbook of China and the Statistical Yearbook of Population and Employment of China.

　　The main statistical indicators of the above three types of population data will be published in the annual data in the database of the National Bureau of Statistics.

　　Why is the trend reflected by census data inconsistent with that published in non-census years?

　　The population in non-census years is calculated according to the sampling survey data of that year. Due to the missing rate of sampling surveys in some years, there will be some deviations in the estimated population as a whole, and these deviations will continue to accumulate with the passage of time.

　　Carrying out the population census once every 10 years can comprehensively find out the number, structure and distribution of China’s population, let us know more clearly the development of China’s population in the past 10 years, and provide extremely valuable data for better studying population issues and formulating population-related policies.

　　So how to deal with this inconsistency? According to international practice and common practice, after the census, the annual data published between the two censuses are generally revised according to the census results, so as to reflect the population development track more truly and objectively. In the sixth national census and the just-concluded fourth national economic census, historical data were also revised according to census data. At present, this work is in progress, and the relevant data will be released on schedule after the revision is completed.

　　Is the population statistics based on household registration or residence?

　　At present, China’s population census and population survey are counted and summarized according to the resident population. The time standard for judging the permanent population is half a year, and the space standard is township, town and street.

　　The resident population is an important basic data for formulating the national economic and social development plan, evaluating the national economic production capacity, and evaluating the welfare level of residents. It has a wide range of applications, such as financial expenditure, urban construction, housing construction, allocation of public facilities, education investment, medical investment and public utility investment, etc., which need to be planned according to the size of the resident population.

　　The registered population refers to the registered population in a certain area, regardless of whether they go out or not, as long as they register their permanent residence in the public security household registration management department. The data of registered population is counted by the public security department. For a long time, China has established a set of perfect household registration statistics and management system, which has played an important role in social management.

　　How is the floating population data counted?

　　Floating population refers to the population whose residence is inconsistent with the township street where the household registration place is located, and who has been separated from the household registration place for half a year or more (excluding the separation of households within the municipal area). The survey indicators used to judge and reflect the floating population include: the place of registration, the place of residence at the time of investigation, the time of leaving the place of registration and the reasons for leaving the place of registration. The National Bureau of Statistics formulates a demographic survey system according to the Statistics Law of the People’s Republic of China, conducts demographic surveys on a regular basis, and publishes major demographic data such as permanent population, birth population, dead population, urban and rural population and floating population.

　　Line up for spicy food.

　　Tempting Gansu mala Tang.

　　"Bouquets of vegetables" are one after another, and enthusiastic diners are one after another. After Tianshui Mala Tang went out of the circle, this "sky-splashing flow" also began to flock to Lanzhou, and the passenger flow of major Mala Tang shops in the city continued to rise obviously. Embracing this wave of traffic dividends, on March 20th, famous local restaurants in Lanzhou took advantage of the situation to offer a new "Gansu Mala Tang" and add another fire with innovative dishes. Even the University of Science and Technology Beijing, thousands of miles away, issued an official announcement, "The campus canteen window, authentic Tianshui Mala Tang in Gansu, is officially launched"!

　　A Lanzhou hot spicy dip famous store huo Shang Jia huo

　　When visiting Lanzhou, Jin Lan Mala Tang in Anning District must be on the must-eat list.

　　At noon on March 19, looking at the endless diners, Ms. Chen, a citizen of Lanzhou, lamented: "Jin Lan Mala Tang, which is deeply loved on weekdays, has become more popular recently!" This is an old-fashioned Mala Tang shop in Lanzhou. The proprietress’s name is Wen Jinlan, and she is from Longnan, Gansu Province. She has been here for more than 20 years. After the hot spicy dip in Tianshui, more and more diners came here, and sometimes they even had to wait in line for an hour to eat.

　　In order to meet the huge passenger flow, it is normal for Wen Jinlan to get up early for nearly 20 hours every day. The reason why it is popular, in the view of the proprietress Wen Jinlan, is because of "popular taste, everyone likes it". The raw materials such as Gangu pepper, Wudu Dahongpao pepper, vermicelli specially customized from Dingxi and grain vinegar produced nearby have jointly contributed to the mouth-watering "spicy and hot".

　　"A large pot of vegetables, all kinds of ingredients wrapped in red juice, a spoonful of crisp sour radish, and the smell of oily spicy seeds between chopsticks directly hit the taste buds." Every meal, Yanji Mala Tang in Zhengning Road, Chengguan District, all the tables inside and outside the store are full. Many people ask, after more than 30 years of opening, people are so popular that there must be an exclusive secret recipe, right? Mr. Zeng, the boss, said frankly: "My wife and I are out-and-out Jianyang people in Sichuan. We have lived in Lanzhou for decades. We improved and adjusted the proportion of juice according to the tastes of local people, which reduced the hemp degree of pepper. It brings together Gansu local materials such as Dingxi Kuanfen and Gangu Chili, forming a unique flavor of Gansu Mala Tang. "

　　B Lanzhou local catering enterprises innovate dishes.

　　On March 20th, Duanji Hotel in Yantan, Lanzhou officially launched the new dish "Gansu Mala Tang". Yang Guoyan, Chairman of the Folk Food Committee of Longcai Association and Deputy General Manager of Lanzhou Duanji Catering Management Co., Ltd., told Benben News reporter: "In order to meet this wave of traffic, we have developed a new dish close to Tianshui Mala Tang, with ingredients such as Gangu Chili, Dingxi Kuanfen and Qin ‘an Zanthoxylum. As a Longcai hotel, our goal is to create a &lsquo; Ganwei hot spicy dip &rsquo; The alternative ingredients will be more extensive, adding lily, yak meat and so on. " Yang Guoyan said that many employees in the store are from Tianshui. Through repeated trial production for many days, this new product has been officially launched.

　　"After Tianshui Mala Tang is on fire, how can we seize this wave of traffic and continue to undertake this heat to Lanzhou? In fact, we still have to work hard on product innovation." Yang Guoyan said, "Gansu is more delicious than mala Tang, Wuwei &lsquo; Three sets of cars &rsquo; , Zhang Ye &lsquo; Stir-fry firecrackers &rsquo; , Longnan stirred up the group &hellip; &hellip; Longshang cuisine has a long history. How to make use of this mala Tang craze to make all kinds of snacks in Gansu known to more people and promote them to the whole country requires not only the help of the cultural tourism department, but also the joint efforts of the catering industry and other departments. "

　　C "Gansu Mala Tang" online orders skyrocketed.

　　According to the data of Meituan, since March, the search volume of keywords related to "Gansu Mala Tang" has increased by 18.5 times from last month, and the number of public comments has soared by 13.2 times. The take-away orders of Gansu Mala Tang increased 66 times from last month. Beijing, Xi ‘an, Jinan, Shanghai and Tianjin are the top five cities in search volume.

　　At the same time, the popularity of Tianshui Mala Tang has also driven the growth of local cultural tourism consumption. The booking volume of travel orders in Tianshui City, Gansu Province increased by 71.8% compared with the same period of last year. Among them, the order volume of hotels and homestays increased by 73.6% year-on-year, and the order volume related to scenic spots increased by 216.8% year-on-year. Maijishan Grottoes, Fuxi Temple, Maijishan Hot Springs, Xianrenya and Yuquan Temple are the top five scenic spots in terms of order volume. Shaanxi, Henan, Jiangsu, Guangdong, Ningxia, Beijing and Sichuan are the top provinces and cities in the source of off-site orders.

　　On various social platforms, many netizens called for authentic Gansu Mala Tang to be eaten in their hometown, and called on Tianshui people to open stores in their hometown. Some physical stores that see business opportunities are trying to seize the opportunity &hellip; &hellip;

　　Gansu Beijing Office, located in Beijing Feitian Mansion, has recently put up "Gansu Mala Tang", attracting many netizens to taste the punch card. And a female shopkeeper from Tianshui also decided to open a Gansu Mala Tang restaurant in Sanlitun, one of the hottest business districts in Beijing, which is expected to be officially opened in half a month.

　　On March 19th, University of Science and Technology Beijing issued a document saying that "Gansu Tianshui Mala Tang" will be launched in the school cafeteria at noon. In order to reflect the authenticity, the school emphasized that "soul juice" is all from Gansu, and it brings together two ingredients of Tianshui, namely Gangu pepper and Qin ‘an pepper. The potato powder is elastic and smooth, Gangu chili pepper is full of oil, and the most delicious thing is the intersection of fresh hemp and Qin ‘an pepper. In fact, as early as 2012, the school established a fixed-point assistance relationship with Qin ‘an County, Gansu Province, and purchased Qin ‘an pepper every year. This year, a new potato powder procurement project was added, and the canteen master went to the local area for research and study, bringing students a better experience.

　　Searching with "Gansu Mala Tang" as the key word through Tianyanchao platform, in the past three months, there have been more than 200 new Mala Tang shops in China. Among them, since February this year, there have been more than 150 newly opened Gansu Mala Tang shops in China. According to the data of Tianyancha Professional Edition, up to now, there are more than 9,600 mala Tang related enterprises in Gansu, while there are nearly 900 related enterprises in Tianshui City alone.

　　Text/Figure Benliu News Lanzhou Morning News reporter Xu Jingwen

Jing Zheng Fa [2018] No.30

District People’s governments, municipal government commissions, offices and bureaus, and municipal institutions:

　　In order to thoroughly implement the Supreme Leader’s Socialism with Chinese characteristics Thought in the New Era and the spirit of the 19th National Congress of the Communist Party of China, fully implement the decision-making arrangements of the CPC Central Committee and the State Council on stabilizing employment, take multiple measures simultaneously and comprehensively, and ensure the smooth completion of the employment objectives and tasks in this city and the sustained and stable employment situation in the current and future period, according to the spirit of "Several Opinions of the State Council on Doing a Good Job in Promoting Employment in the Current and Future Period" (Guo Fa [2018] No.39), combined with the actual situation, the following implementation opinions are put forward:

　　First, support the stable development of enterprises

　　(1) Increase the support for stabilizing posts. Since January 1, 2019, 50% of the unemployment insurance premium actually paid in the previous year can be returned to the insured enterprises that have not laid off employees or laid off fewer employees. From January 1 to December 31, 2019, for the insured enterprises that face temporary production and operation difficulties and are expected to recover, and insist on not laying off employees or reducing layoffs, the return standard can be determined according to the monthly per capita unemployment insurance premium and the number of insured employees in the previous year of this city for six months.

　　(2) Continuously optimize financial services. Improve the policy financing guarantee system, increase the scale of financing guarantee for small and micro enterprises, guide more financial resources to support entrepreneurial employment, and further alleviate the problem of financing difficulties for small and micro enterprises. Banks and other institutions that have made outstanding achievements in the work of business guarantee loans may be rewarded according to 1% of the newly issued business guarantee loans in that year.

　　(3) Guiding and stabilizing labor relations. Strengthen the supervision and management of enterprises’ implementation of the labor contract system and the collective contract system, encourage enterprises to carry out collective consultations with employees, urge enterprises to protect the legitimate rights and interests of employees according to law, further build harmonious labor relations and stabilize employment.

　　Second, encourage entrepreneurship to drive employment

　　(four) increase the support for the discount of business guarantee loans. Small and micro enterprises registered and operated in this city, when the number of newly recruited people who meet the application conditions for business start-up guarantee loans reached 25% of the existing employees (15% for enterprises with more than 100 employees) and signed labor contracts with them for more than one year, can apply for business start-up guarantee loans with a maximum of 3 million yuan according to the standards of the number of recruited people and the amount of each person not exceeding 150,000 yuan, and the discount funds will be borne by the finance. Increase the maximum amount of personal small convenient loans from 100,000 yuan to 150,000 yuan.

　　(5) Strengthen the construction of entrepreneurial carriers. Accelerate the construction of business incubation carriers for key groups and provide low-cost venue support, guidance services and policy support for entrepreneurs; According to the number of entities, the incubation effect and the employment effect, the business incubation base will be rewarded. Support areas with stable employment pressure to provide free business venues for unemployed people to start their own businesses. Strengthen the construction of the "Growth Enterprise Market for College Students" in this city’s regional equity market, and provide professional services such as project incubation, capital docking, equity custody, training and guidance for entrepreneurial enterprises.

　　Third, carry out skills training to improve the quality of employment

　　(six) support enterprises in difficulty to carry out skills training for employees. From January 1 to December 31, 2019, difficult enterprises can use the education funds of enterprise employees to carry out on-the-job training for employees by themselves or by entrusting institutions with corresponding training qualifications in this city. Employees who have obtained corresponding vocational qualification certificates or vocational skill grade certificates after training shall be subsidized by their enterprises according to 50% of the subsidy standard for technical skill upgrading; To carry out non-level skills training and each person’s training time is not less than 20 class hours, and give enterprise subsidies according to the standard of 500 yuan per person.

　　(seven) to encourage workers to improve their professional skills. From January 1, 2019 to December 31, 2020, the application conditions for technical skills upgrading subsidies in this city were relaxed from employees of enterprises who participated in unemployment insurance for more than 3 years to those who participated in insurance for more than 1 year; Persons with employment difficulties in urban and rural areas in this city who have not received unemployment insurance benefits can enjoy cost of living allowance, which is not less than that in 35 yuan, per person per day during the training period, and cost of living allowance policy only enjoys it once per person per year.

　　(eight) to mobilize social forces to participate in vocational training. Support all kinds of vocational colleges (including technical colleges), ordinary colleges and universities, vocational training institutions and qualified enterprises to undertake vocational skills training or entrepreneurship training for unemployed people and rural migrant workers, and give vocational training subsidies according to regulations. The subsidy standard is determined according to the training cost, training duration, market demand and obtaining relevant certificates. Timely study, adjust and enrich the catalogue of vocational training subsidies, and expand the benefits of policies.

　　Fourth, accurate policy to help employment

　　(nine) to expand the scope of employment trainee subsidies. From January 1, 2019, the scope of employment trainee subsidies will be expanded from unemployed college graduates who have left school to registered unemployed people aged 16-24 and rural laborers who have transferred employment registration; Organize them to participate in employment internships for no more than 12 months, give employment internship subsidies according to regulations, and appropriately raise the subsidy standards.

　　(ten) to improve the employer’s post subsidy standards. Employers will be encouraged to recruit people with employment difficulties in urban and rural areas, retired soldiers and laid-off workers from enterprises, and the post subsidy standard will be raised from 5,000 yuan per person per year to 8,000 yuan per person per year.

　　(eleven) to promote the employment of rural labor. Vigorously develop industrial projects with quick results and high returns to help rural laborers find jobs nearby. Encourage outstanding young people to return to their hometowns to start businesses and promote farmers’ employment. Broaden the channels for rural labor to transfer employment, support rural labor who are willing to go out for employment in urban public service posts, and implement relevant policies such as post subsidies and social insurance subsidies. Give full play to the role of rural public welfare posts and enhance the ability to provide care for rural people with employment difficulties.

　　V. Optimizing services to boost employment

　　(twelve) the implementation of permanent service. Unemployed people in this city and rural laborers who require the transfer of employment can apply for unemployment registration, transfer of employment registration and other businesses in the social security offices in the streets (towns) of their permanent residence, enjoy employment and entrepreneurship services nearby, and apply for employment and entrepreneurship support policies at the municipal level and in the districts where their permanent residence is located. People with employment difficulties in urban and rural areas can receive employment assistance in their permanent residence.

　　(13) Improve service quality. Actively use the "internet plus" model, build a network service platform for employment and entrepreneurship, promote departmental information sharing, streamline work links, and reduce application materials, so that "information runs more and people run less errands". Actively carry out policy propaganda, announce the policy list, bidding process, subsidy standard, service organization and contact information, supervise the complaint telephone number to the society, go deep into enterprises to preach policies, understand difficulties, solve problems, do a good job of helping, and promote the implementation of various employment policies and services.

　　(fourteen) to ensure the basic livelihood of the people in need. We will fully implement the unemployment insurance system and steadily raise the level of unemployment insurance benefits. A temporary living allowance of 3,000 yuan will be given to registered unemployed people who have difficulties in life and do not meet the conditions for receiving unemployment insurance benefits. We will integrate urban subsistence allowances, rural subsistence allowances, and low-income family identification systems, expand the scope of assistance, lower the threshold for assistance, and timely include families that meet the minimum living guarantee conditions into the minimum living guarantee scope. Improve the city’s temporary assistance system, give temporary assistance to qualified personnel, and help people in need to get out of trouble.

　　Sixth, improve the safeguard mechanism

　　(15) Strengthen organizational leadership. Give full play to the role of the municipal social security and employment work leading group, improve the working mechanism, and make overall plans for the analysis, policy formulation, guidance and inspection of the city’s employment situation. The relevant municipal departments and district governments should earnestly assume the main responsibility of promoting employment, strengthen communication and close cooperation, and do their best to promote employment.

　　(sixteen) to strengthen publicity and guidance. Guide enterprises to stabilize employees’ employment through transformation, training and job transfer, and support "double innovation"; Guide workers to establish a correct concept of employment, actively improve their employment skills, and realize employment and entrepreneurship through their own efforts. It is necessary to mobilize the forces of all sectors of society to form a joint force to promote employment.

　　(seventeen) optimize the financial security. Comprehensively sort out the existing capital projects that guarantee basic living, promote employment and stabilize employment, and on the basis of maintaining policy continuity and stability, merge and simplify the capital projects and use methods to improve the efficiency of capital use. Strictly implement the real-name management of employment assistance targets and effectively ensure the safe operation of funds.

the people’s government of beijing city

December 20, 2018

BA.4 and BA.5, the new branches of Omicron with stronger communication power, have recently attracted attention. The new branch has triggered a new infection peak in South Africa, and the Portuguese National Institute of Health also estimates that its growth advantage is 13% more than that of BA.2.

Screenshots from the nextstrain website show that the different Omicron branches represented by yellow, orange and red are iterating rapidly within half a year, and the new branches represented by orange and red are also expanding in the cracks.

Screenshot of nextstrain website. According to the uploaded sequencing data, since December last year, the mainstream branches in Omicron have gradually changed from BA.1 (shown as 21K) to BA.2 (shown as 21L) to BA2.12.1 (shown as 22C), and the area occupied by new branches is also expanding.

The new branches of Omicron are frequent. Is the current COVID-19 vaccine still effective? Do the branches BA.2 and BA.5 need their own vaccines? Should the update of COVID-19 vaccine keep up with the variation of virus? How to keep up with the virus mutation? With the above questions, the reporter of Science and Technology Daily contacted and interviewed a number of industry experts.

Is the current vaccine still effective?

Does the mutation branch in Omicron constantly trigger new infection peaks, which means that the current COVID-19 vaccine will be invalid?

Authoritative experts in the industry responded to the Science and Technology Daily reporter and said: "Current vaccines can still provide the most basic protection in ensuring the reduction of severe illness and death.. The epidemic in COVID-19 has been going on for two and a half years. At present, it seems that there is no possibility for Covid-19 to achieve zero infection through vaccination. COVID-19 vaccine can ensure the effect of reducing infection and avoiding serious illness and death. "

Regarding the role of the current vaccine in epidemic prevention and control, the person in charge of vaccine-related production enterprises in COVID-19 holds the same view: "The existing vaccine is no problem in preventing severe illness and death at present, but it will not be 100% anti-infection."

Many statistics or research results from the real world show that the current vaccine plays a significant role in preventing severe illness and death. For example, the latest data in Hong Kong (as of May 25th) showed that the mortality rate of those infected in Omicron who were not vaccinated was 3.04%, while the mortality rate of those infected with three doses of vaccine dropped significantly to 0.04%.

Do the branches BA.2 and BA.5 all need their own vaccines?

According to WHO’s latest weekly report on epidemiological progress in COVID-19 (May 25th),Omicron BA.2 and its progeny pedigree (BA.2.X) have become the main popular variants in the world.At present, the relative proportions of BA.2.X, BA.4 and BA.5 are 94%, 0.8% and 1% respectively.

This shows that during the evolution of Omicron mutant, the branch BA.1 is disappearing. However, the reporter learned that at present, most vaccines against Omicron in China are designed and developed for BA.1.

Whether it is necessary to develop new vaccines for new branches, the industry generally judges from the perspective of vaccine protection: if the activity of neutralizing antibodies produced by the original vaccines against mutant strains is greatly reduced, it is necessary to develop new vaccines; If it still has a good neutralizing effect on the mutant, there is no need to develop a new vaccine.

Although Omicron strain mutates rapidly and different branches appear, butNew vaccines will not be introduced for each branch, and there is no need to do so.. Relevant experts reminded: "If you continue to monitor, you will find that many mutations will disappear soon."

Can vaccine update keep up with virus iteration?

In the technical route of vaccine development in COVID-19, the design cycle of mRNA vaccine is short. On the basis of a mature platform, the design can be completed within 7 days, and the preclinical trials including animal experiments can be completed in about one month.

Industry experts engaged in the research and development of mRNA vaccine said that for the variant branch, the mRNA vaccine does not need to obtain the strain, but only needs to optimize the vaccine sequence according to the variant sequence and test the expression efficiency, and then pre-clinical trials can be carried out. Covid-19 Omicron mutant mRNA vaccine, developed by Suzhou Aibo Bio, China, has been approved for clinical research in UAE.

In response to virus variation, the technical route of inactivated vaccine can also complete the preclinical study of new strains in a short time by establishing an emergency system. The reporter previously learned that it can be advanced to the clinical trial application stage about 2 months after obtaining the new strain.

Keep up with the variation, can COVID-19’s vaccine market learn from the "flu model"

In order to cope with the frequent mutation of viruses, there are precedents for vaccine updates to follow closely. For example, the influenza virus vaccine is recommended by WHO every year, and countries produce new influenza vaccines accordingly.

In order to keep up with the variation in Covid-19, can the "flu model" be used for reference in the marketing of vaccines in COVID-19?

“It is estimated that the future development of COVID-19 vaccine needs to adopt the influenza model.The authoritative experts mentioned above responded, but WHO is unable to recommend mainstream strains through monitoring now, because the pandemic is not over yet.

Another advantage of the "flu model" is that it greatly shortens the time to market for new vaccines. Because there is no need for re-approval, its batch issuance system can effectively shorten the period from vaccine development to marketing. Experts in the industry said that after polishing and construction, various technical routes and platforms have gradually matured, the research and development speed has been accelerated, and the production process has been stable.If the "flu model" can be adopted in the development and marketing of vaccines in COVID-19, the time to market for new vaccines will be greatly shortened.

WHO has revealed some unexpected phenomena in its weekly epidemiological report: available data show that BA.4, BA.5 and BA.2.12.1 spread faster in countries where BA.1 was once prevalent, but less in countries where BA.2 was prevalent; The vaccination degree of each country may have an impact on the popularity of the new branch of Omicron. Visible,Covid-19 mutation and vaccine immunogenicity are mutually causal and widely related, and updating the vaccine in time may have an impact on virus mutation.

Source: Science and Technology Daily

Original title: "Omicron iterates fast, is it necessary to be" anxious "about the vaccine? 》

Read the original text

1905 movie network news　Last weekend (01.18-01.20), the box office revenue in North America totaled $129 million, up 8.2% from the previous week. Monday is Martin Luther King Memorial Day, and we will continue to have a holiday. Among the new films on the list, M Knight Shamalan’s new film "Mr. Glass" earned $40.58 million in the first three days of the first weekend, which was close to $40.01 million in the first week of "Split" in 2017 and higher than $30.33 million in the first week of "Never Die" in 2000. Not surprised or pleased. The media mostly think that the content is too full and too anxious, but there is no emotional touch. They think that they are not attracted to fans of "The Dead Robber" or "Split" and become ungrateful at both ends. Another new film is a slightly niche animated film "Dragon Ball Super: brolly". The plot is based on the animated series "Dragon Ball". After telling the story of Wukong and brolly, it is biased towards fans. In the first week, it won 10.65 million US dollars in 1233 theaters in North America, but it attracted a limited audience and was not optimistic about its subsequent box office development.

"Mr. Glass" is too full of word of mouth, and the fans of "Dragon Ball Super: brolly" are serious

Recommended star rating of Mr. Glass: ★★★

"Dragon Ball Super: brolly" Recommended star rating: ★★★ (specific fan direction)

On the weekend of Martin Luther King’s Day, M Knight Shamalan’s new work "Mr. Glass" earned 40.58 million US dollars at the box office in North America from Friday to Sunday, which was close to 40.01 million US dollars in the first week of "Split" in 2017 and higher than 30.33 million US dollars in the first week of "Never Die" in 2000. In all the Martin Luther King Memorial Weekends, this box office ranked third, only behind the $41 million of "Sasaki Brothers" in 2014 and the $89 million of "American Sniper" in 2015. The production cost of Mr. Glass is $20 million, and the global box office has reached $90 million. These figures undoubtedly prove Shamalan’s ability to make money again. In fact, even in the low tide of Shamalan’s poor reputation, many of his films were very profitable. For example, in 2008, the production cost of "Death" was 48 million US dollars, and the final global box office was 163 million US dollars. In 2004, the production cost of "Mystery Village" was 60 million US dollars, and the final global box office was 256 million US dollars. What he really didn’t earn was only.

At present, the cinema score of Mr. Glass is B, IMDb score is 7.2, MTC score is 42, and the freshness of rotten tomatoes is 36%. "Hollywood Reporter" commented: "As the final part of the trilogy, this film is like a mixed bag, twisting all the previous narrative clues into one, but unfortunately trying too hard to tell the audience that Shamalan has a very special idea on the popular comic adaptation story, but the result is not shown." "Variety" said: "It’s still very happy to see Shamalan return, but" Mr. Glass "takes up more of our time, but it can’t create any touches, which makes people feel busy and dazzling, but there are few moving moments of emotional resonance." "International Screen" thinks: "Apart from McEvoy’s performance as a smoke bomb and Bruce Willis’s convincing charm, the whole film has actually not gone far in the concept of’ what happens when people become superheroes’." Due to the poor reputation, the follow-up box office track of Mr. Glass may be more similar to the Clover Files, which was opened on the weekend of Martin Luther King’s Day in 2008. The film earned $40 million in the first week and $80 million in the local box office.

Another noteworthy new film last weekend was the classic IP cartoon "Dragon Ball Super: brolly", which was only opened in 1,233 theaters in North America, aiming at clearly attracting a specific fan base, and won $10.65 million at the box office in three days in the first weekend. The story of "Dragon Ball Super: brolly" is a continuation of the upcoming TV animation "Dragon Ball", which tells the story between Saiyan brolly and Wukong. The film was nominated for the best cartoon in the 42nd Japanese Film Academy Award and was very popular among fans. At present, the media scores and fans’ scores of all platforms are very high, with IMDb score of 8.6, MTC score of 64 and the freshness of rotten tomatoes of 80%. The Los Angeles Times said: "brolly is ready to give Dragon Ball fans everything they want in a movie, and other viewers may feel lost in this world." Midwest Film Journal also thinks: "For the novice Dragon Ball, this film provides a dazzling animation time." There are also some media that don’t like it, such as "Movie Country", which means: "This is a meaningless garbage culture animation only for fans."

Old movies: "Neptune" local over 300 million "Upward" has a strong box office stamina.

Warner Bros.’ s superhero movie Neptune has entered its fifth week. After the weekend, the film’s box office outside North Captain America: Civil War has reached 759 million US dollars, surpassing’s 745 million US dollars, and the local box office has also exceeded 300 million US dollars. At present, the film’s global total box office is 1.063 billion US dollars, which is still 3 million US dollars short. Amber Heard’s Neptune can surpass Johnny Depp’s highest-grossing Pirates of the Caribbean: The Coffin. At the same time, Aquaman is also the movie with the strongest box office stamina after Teenage Mutant Ninja Turtles: The Age of Mutations in 2014. It is expected that Aquaman will have a good room for growth before The Lego Movie 2: The Second Part and Listen to Men’s Hearts come out on February 8.

In the following week, Upward Bound kept quite steady, with the box office of $15.6 million in three days over the weekend, which was only 23% lower than that in the first week. Earlier, many films in kevin hart fought bravely in Martin Luther King’s weekend, such as the above-mentioned Sasaki Brothers, Customized Best Man and Sasaki Brothers 2, and so on. This time, Upward Bound was opened in this schedule one week ahead of schedule. At present, the total box office of Upward is US$ 43.98 million. As long as it exceeds the US$ 48.7 million of Supersize Beauty last year, it will become the third domestic box office of STX Entertainment after bad mother and Christmas of Bad Mom. Sony’s Spider-Man: Into the Spider-Verse currently has a global box office of US$ 322 million, which has surpassed The LEGO Batman Movie’s US$ 311 million. The production cost of Spider-Man is US$ 90 million.

This week’s preview: Adventure "King Boy" Playing through the thriller "Quiet" arouses expectations.

This weekend (01.25-01.27), Fox’s youth movie "King Boy" and Matthew McConaughey and Anne Hathaway’s crime thriller "Quiet" will be widely opened in North America.

Fox’s "The King’s Boy" tells the story of a little fat boy, Alex, who accidentally pulls out and passes on the "sword in the stone" mentioned by H. As a destined little hero, he needs to unite his friends and the legendary wizard Merlin to fight against the eccentric witch Morgana. This is a story from modern times to legend, which will be opened in more than 3,400 theaters in North America this Friday. The crime thriller "Quiet" starring Matthew McConaughey and Anne Hathaway was postponed from last October to this week. It tells the story that Baker Dill, the captain of a fishing boat, received a request from his ex-wife Karen to help her kill her violent current husband. Karen’s appearance was forgotten in Jandyr, but in fact, the current situation is also city by the sea. The film will open in more than 2500 theaters this Friday.