Special feature of 1905 film network It has been 2309 days since the film "Lonely Lost" was released. In the last two or three days, it has been mentioned again. And what caused all this is a very emotional good news — — The DNA comparison of Guo Gangtang’s son, the prototype of Lost Orphan, succeeded!

Speaking of the touch when I just saw this news, Miao Yao, the host of this issue, said with emotion: "There are two exclamation points in my heart. The first exclamation point was actually found, and the second exclamation point was finally found."

The word "finally" expresses our faint hope that Guo Gangtang will find his son because of his persistence. In 24 years, he traveled all over 31 provinces, autonomous regions and municipalities in China and broke 10 motorcycles. Guo Gangtang’s persistence finally got the best answer.

In 2010, it was precisely because of Guo Gangtang’s insistence that director Peng Sanyuan saw the news of his search for children and paid attention to the abducted groups, and made the film "Lonely".

Wang Jian, a guest commentator of Today’s Film Review, said: "It is precisely because of the social reality reflected in this film that our whole society pays more attention to this phenomenon that we have changed the corresponding legal text and upgraded the corresponding crimes of abducting and selling children and women, including the public security organs launching a" reunion "action and taking more powerful measures to save these broken families."

The social reality reflected in "Lonely Lost" and the influence of Andy Lau, the leading actor, made more people pay attention to this social problem. When talking about the original intention of filming, film director Peng Sanyuan was also very emotional.

"The original intention of filming at that time was to hope that the whole society would pay special attention to such groups. They knew that such a thing would happen around us, and they should know that the evil chain of traffickers always existed."

"On the one hand, I wanted to help the abducted children go home and help the parents who are looking for children to reunite with their loved ones as soon as possible."

"There is also the hope that we can remind the public that we should protect our children and avoid being separated from them because of negligence or even because of gang robbery by criminals. Therefore, it is not too much to protect our children. If we can do this, I feel that our film has not been shot in vain."

The director’s two wishes have now come true, and the film has not only been shot in vain, but also updated its own best ending. Many viewers are particularly concerned about whether "Lonely Lost" will be shown in the cinema in today’s situation, and many netizens especially hope that Peng Dao can shoot the story after the reunion.

Director Peng Sanyuan also responded to the earnest invitation of the audience and netizens: "In fact, I have seen many netizens’ appeals. It is possible for us to shoot Lonely 2, but we should not bother Guo Zhen and Guo Gangtang. On the contrary, I feel that this father and son should no longer enter the public eye from now on, and let them quietly spend time repairing their family ties that have been cut off for 24 years. "

"Because of the renewed affection, it takes time. Only time can cure everything. Maybe they need two years, maybe three years, five years or ten years. So I think that up to now, we will not use another film to disturb their peaceful life, but I will pay attention. " Continue to pay attention not only to the running-in of affection between Guo Gangtang and Guo Zhen’s father and son, but also to other groups that are still separated from their relatives.

In this issue, guest Wang Jian also mentioned another film, Dying to Survive, which reflects social reality. "As Director Peng said just now, she made such a film because she paid attention to reality, and will not give up her continued concern for reality because she finished the film. Many of our films are actually affecting reality. For example, Dying to Survive directly promoted our corresponding anticancer drugs into our medical insurance catalogue, such as the revision of our Drug Administration Law. "

Wang Jian mentioned: "Art works must first reflect real life. At the same time, if you can change the reality through your own strength in the process of artistic creation and let the society develop in a better direction, this is in itself a very important responsibility for our film practitioners. "

Indeed, as a filmmaker, it is very precious to reflect the social reality we see to the public in artistic creation.

"The development and progress of our society has come to this day. In fact, the whole social group has become more and more detailed. Whether each minority group has received social attention and care, and his problems and demands have been solved, from this point of view, it also spurs and encourages more artists to pay attention to every corner of our society and pay attention to everyone’s inner demands. "

The Lost Orphan is undoubtedly a very successful film, which makes us pay attention to the group of lost and abducted children. At the same time, we also hope and believe that more and more movies will reflect and influence reality and make society better.

　　Changchun, China, March 11 (Reporter Guo Dongyu) How important is a good seed for food production?

　　"Good seeds, good rain and good moisture can make us look forward to a bumper harvest year." Han Fengxiang of Fenghuangshan Agricultural Machinery Farmers’ Professional Cooperative in Lishu County, Siping City, Jilin Province said.

　　"The contribution rate of excellent varieties to grain production has reached more than 45%, which plays a vital role in national food security." Zhang Zhijun, a researcher at the Corn Research Institute of Jilin Academy of Agricultural Sciences, said.

　　"I have a dream, buried in the soil, convinced that it is different. Light gives it hope, rain nourishes it and grows with the seeds. " Yuan Longping, the father of hybrid rice, said.

　　A small seed, one tied to the people’s rice bowl and the other tied to the national strategy (photo by Yang Guangwang)

　　This year, the No.1 Document of the Central Committee proposed that the seed industry should be revitalized in depth, the pace of industrialization of corn and soybean biological breeding should be accelerated, the pilot scope should be expanded in an orderly manner, and planting management should be standardized.

　　Recently, the reporter walked into Gongzhuling City, the founding unit of the National Modern Seed Industry Park and a national-level rice seed production county, to see how Jilin people on the black land grasped the "core" of grain.

　　Organic fertilizer "waits" for the next field (photo by Yang Guangwang)

　　In the more than 20,000 mu seed field of Hongxiang Seed Industry Co., Ltd. (hereinafter referred to as "Hongxiang Seed Industry") in Gongzhuling City, the land has been turned over and the organic fertilizer has been piled up at the edge of the field. "This seed production base was transferred last year. We used the method of black land protection to produce seeds. After a year of practice, the seed quality is very good." He Wei, general manager of Hongxiang Seed Industry, said.

　　Walking into the seed cultivation room, a fresh new green brings ying ying spring. "This is our trial variety and we are testing the emergence rate." He Wei said, "The seedlings in this germination box grew the day before yesterday, and each leaf of them contains a lot of information, which is very important for us breeders." Here, enterprises invest about 50 million yuan in maize breeding every year. "We carefully selected the seeds and planted them in the experimental field. Through the growth and yield, we found those plants with less diseases, lodging resistance and high yield."

　　A piece of new green "nurtures" the hope of a bumper harvest (photo by Yang Guangwang)

　　In addition to constantly researching and developing new varieties, how to make seeds more suitable for modern agricultural production methods is a problem that the Corn Research Institute of Jilin Academy of Agricultural Sciences is currently thinking about.

　　"At present, one of the main problems in corn production is that the level of mechanized harvesting of seeds is low. At present, the harvesting method is mechanical harvesting of ears or manual harvesting, which is not conducive to large-scale production." Zhang Zhijun, a researcher at the Corn Research Institute of Jilin Academy of Agricultural Sciences, said.

　　In recent years, the corn research institute of Jilin Academy of Agricultural Sciences has taken the research and development of new varieties suitable for modern production methods as its main research goal. "At present, we have cultivated Jidan 66, Jidan 436, and Jidan 81 and 82, which will be approved soon. It can be said that grain harvesting is a strong support for Jilin agriculture to take the lead in realizing agricultural modernization in the future." Lu Ming, deputy director of the Corn Research Institute of Jilin Academy of Agricultural Sciences, said.

　　Researchers overcome the difficulty of grain harvesting by machine (photo by Zhou Linhai from Yangguang. com)

　　Document No.1 of Jilin Provincial Party Committee issued this year made it clear that it is necessary to implement the project of improving corn yield per unit area. Screening and popularizing new maize varieties with density tolerance, high resistance and high yield.

　　"Every seed we develop must first ensure safety and good resistance. No matter what kind of environment, it can grow. The second is high yield, which allows farmers to increase their output after planting. " He Wei said. Hongxiang Seed Industry plans to reach the production capacity of all four design production lines as planned before 2025, meeting the production demand of 100,000 mu. "In the future, we can serve the whole park, let the seed industry in Jilin Province come back and build a spring corn processing base."

　　It is the wish of Jilin breeders to cultivate a good seed and plant a good field, and it is also the road they will always stick to.

　　Hongxiang seed industry farming field (photo by Yang Guangwang Fa Qu Liangliang)

　　According to Voice of China: Recently, Voice of China continued to report a secondary vocational school in Henan — — There are some problems in Henan Polytechnic School, such as forging student lists to obtain state education funds and renting state assets for illegal profits. In this regard, the staff of the Henan Provincial Department of Finance said that the school had previously had some expenses that were not uniformly registered and accounted for in the accounting books set up according to law, and that the school had been punished for privately storing public funds.

　　The Henan Provincial Department of Education said that it had been investigating and verifying the forgery of the student status list to obtain education funds, but it was unable to provide reporters with the list of students used by the school to apply for per capita funding. In fact, in recent years, the problems of enrollment, charging and management of secondary vocational education are not uncommon. Then, how to supervise the chaos in secondary vocational education?

　　Forged the student list, rented the teaching building, and the funds fell into the private "small treasury"

　　Informed sources told reporters that in recent years, there have been many students who dropped out of school early without completing their studies, and the school information still shows that they are studying at school. Based on this, the school has obtained the education funds allocated by the province.

　　Insider: "But what does it mean that students are still registered as students, and they are still registered as students?" That is, as soon as he registered, he handed it to the Education Department. This is not registered, and then this list was handed over to the Finance Department, and this student was dialed. "

　　The school staff provided the reporter with a list of 118 students who dropped out of two colleges early, and the Voice of China reporter verified them one by one. All the students in this list dropped out of school for different reasons in less than one year. However, most of the students’ information shows that they are still in Henan Polytechnic School.

　　Reporter: "Have you been studying in this Henan Polytechnic School for 16 years?"

　　Lost students: "Yes."

　　Reporter: "So you haven’t been there for a while?"

　　Lost students: "About a year."

　　According to the funding basis of the per-student funding of vocational schools in Henan Province, full-time vocational schools allocate funds strictly according to the number of students’ status, and the subsidies for different majors such as arts and sciences range from 5,000 yuan to 7,000 yuan per person per year. For those students who dropped out of school early, but their school status is still in school, the school theoretically received per capita funding.

　　In addition, many school staff reported that the school’s income from renting state assets including the comprehensive teaching building was not recorded, and the principal set up a "small treasury" privately.

　　The number of forgers and the allocation are still being verified, and the private small treasury is fined 10,000 yuan.

　　In response to this matter, the Voice of China reporter contacted the Henan Provincial Department of Education many times. The relevant staff of the Department of Education responded that the relevant situation has been investigated and verified, but the Department of Education does not have a list of students provided by the school to apply for per capita funding, and the funding is the responsibility of the financial department. The reporter then contacted the Henan Provincial Department of Finance, and the staff of the Department of Finance said that the financial department allocated funds according to the data provided by the education department.

　　Staff of the Finance Department: "We still record the number of students provided by the education department into our budget system, and determine its quota according to the number of students."

　　In addition, the staff of the Henan Provincial Department of Finance said that an administrative penalty of 10,000 yuan had been imposed in accordance with relevant regulations.

　　Expert: We should strengthen supervision and improve the funding system and methods.

　　In fact, in recent years, there have been incidents of false enrollment, arbitrary charges, and taking funds from secondary vocational education. In this regard, Wang Jianzhuang, executive dean and chief researcher of Henan Institute of Private Education, said that in addition to the main responsibility of the school, the living environment of secondary vocational schools, the utilitarian consciousness of individual schools and the official standard structure of vocational schools are all factors.

　　Wang Jianzhuang: "Because the competition for students is so fierce, some schools don’t run according to an educational law. Such a school, it tries to get funds through some improper means, and the per capita funding is the main source of funds for their school. Therefore, this will also have problems in system design, and this phenomenon will occur with some loopholes in supervision. "

　　Wang Jianzhuang believes that to completely change this situation, we need the joint efforts of the government, schools and other parties. While improving the quality of managers in secondary vocational schools, we should improve the funding system and methods, establish a mechanism to allocate funds to the extent that graduates serve the society, encourage the growth of high-quality secondary vocational education resources, and realize scientific development.

　　Wang Jianzhuang: "We use it to cultivate students’ other achievements, and its graduates serve the overall evaluation of society to allocate its funds in a planned way. For example, to evaluate a school and a secondary vocational school, there are 300 graduates this year. I will count the employment situation of your graduates through the graduates in the past five years, and I have an indicator of his contribution to the local economic and social development, and then I will give you the funds after this year in proportion, which is better. "

　　Voice of China will continue to pay attention to the progress of the follow-up investigation on this matter.

　　Yang Guang reporter Qian Cheng

Cancer is a big problem in the history of human medicine, and there is no way to completely cure it at present. In the face of cancer with extremely high mortality, life is fragile. No matter whether it is poor or rich, famous or unknown, we often see the news that celebrities have died of cancer, and we can’t help sighing, but there are also some wonderful experiences of anti-cancer success!　 Many cancer patients often lose confidence in life after learning that they have cancer, do not actively treat them, or even resist treatment, and feel that treatment is unnecessary, and treatment is a waste of money. In fact, this idea is not correct. Don’t give up until the last moment. Even if cancer has not been completely overcome, after scientific and reasonable treatment with many patients, life can be continued, and even clinical cure or long-term survival with tumors can be achieved! Nowadays, there are many treatments for cancer. If it is found as early as possible and treated actively, one third of cancer can be cured. Medical "cure" is different from what people usually understand. The clinical cure here refers to the disappearance of symptoms and signs after treatment, and the tumor can not be found after image review for more than 5 years.

Today, Xiaobian, a cancer-free home, will share the stories of four celebrities who have succeeded in fighting cancer, and see how they fight cancer. I hope to give some reference and motivation to all cancer friends!

Kai-Fu Lee: From the late stage of cancer to the disappearance of tumor, chemotherapy+targeted therapy against advanced lymphoma.

　 On September 5th, 2013, 52-year-old Kai-fu Lee, the founder of Innovation Factory, announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from. 　

Lymphoma, also known as lymphoma, occurs in the lymphatic system and is one of the malignant diseases of the blood system. In fact, we are no strangers. Besides Kai-Fu Lee, celebrities such as Luo Jing, Asan and Cindy Lee have also suffered from lymphoma. The incidence of lymphoma is actually not too high in malignant tumors, which is about 5/100,000. It can occur at any age, but it is mainly in middle-aged people aged 30-50. The malignant degree of different types of lymphoma varies greatly, which can be roughly divided into: inertia, aggression and high aggression. Inertial lymphoma is similar to chronic diseases, while high aggression is like a "death warrant"! There are many types of lymphoma, but as long as we know, lymphoma can be divided into Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL), the latter accounting for about 90%, and diffuse large B-cell lymphoma is the main type (40%~50%). When you know that you have stage 4 or systemic metastasis, it doesn’t mean that your condition is very serious and there is no cure. Don’t give up treatment easily. The treatment of lymphoma is mainly systemic chemotherapy and radiotherapy. Li Kaifu’s treatment plan is that bendamustine (bendamustine) is combined with rituximab (rituximab, trade name: rituximab). Different from traditional chemotherapy drugs, rituximab is called "an artifact to accurately combat lymphoma". It is an anti-CD20 monoclonal antibody against malignant B lymphocytes, with good effect and little side effects, and it is a milestone in the treatment of lymphoma. 　

Since rituximab was listed in the United States in 1999, the 5-year survival rate of patients with diffuse large B-cell lymphoma has increased to 50%. Rituximab used to be a self-funded drug, which was expensive. Now it has been included in the scope of medical insurance reimbursement, which has enabled many cancer friends to enjoy the fruits of modern medical progress.　　

In addition, Kai-Fu Lee also tried many kinds.Natural therapyIn order to finally defeat cancer.

Keeping a good sleep is the most important thing. Staying up late for a long time may reduce the body’s immunity, and his lymphoma is a common cancer in the immune system. Therefore, after suffering from cancer, he made a schedule to protect his immunity. It is necessary to keep your mouth shut when disaster comes from your mouth. It is particularly important for cancer patients to keep their mouths shut, and maintaining good eating habits can better fight cancer. Kai-fu Lee suggested that everyone should eat more grains, beans, fruits and vegetables, and take a balanced intake. 3. Take your legs apart and exercise properly to inhibit cancer cells. Many studies have confirmed that exercise is beneficial to the rehabilitation of cancer patients and can reduce the risk of cancer recurrence after operation. However, it should be reminded that not all exercise is suitable for cancer patients, and it is suggested to use the principle of "not feeling tired". 4. Good attitude, get twice the result with half the effort When fighting cancer, it is very important to keep a good attitude, which has a great influence on cancer treatment.

Pancreatic cancer: steinman "tried medicine by himself", and the dendritic cell vaccine made him live for four and a half years!

　 Speaking of vaccines, everyone is actually familiar with them, except for the common hepatitis B vaccine and influenza vaccine, and the Covid-19 vaccine that we have vaccinated up to now. In fact, cancer vaccine is also a form of immunotherapy, which can prevent cancer from developing or kill existing tumors by stimulating or restoring the human immune system. In the 21st century, the high incidence of cancer has attracted the attention of the global medical community. As a prominent tumor vaccine, dendritic cell vaccine has been a research hotspot in this field. When it comes to dendritic cell vaccine, we have to mention a legendary figure-ralph steinman, winner of the 2011 Nobel Prize in Physiology or Medicine. 　　

ralph marvin steinman After the diagnosis of pancreatic cancer in 2007, steinman actively tried a therapeutic vaccine (DC vaccine) based on dendritic cells. With the help of this "cellular immunotherapy", his life was extended from the expected months to four and a half years.　 There is a rule in the Nobel Prize that they never give this prize to people who have passed away. However, ralph steinman broke this rule because he passed away quietly three days before receiving the call for winning the prize. Therefore, Staman is also called the most regrettable Nobel Prize winner.

　 0one　　Suffering from pancreatic cancer with a mortality rate of 95%, he devoted himself to the research of DC vaccine.

In 1973, steinman discovered dendritic cells in the spleen of mice, and put forward the concept of dendritic cells. In 2011, steinman shared the Nobel Prize in Physiology or Medicine with Jules Hoffman and Bruce Beutler for "discovering dendritic cells and their role in the acquired immune system".

Pancreatic cancer, which claimed steinman’s life, is one of the malignant tumors with the highest mortality rate at present. The mortality rate of this disease can reach 95% clinically, and it is very rare for patients who can survive for 5 years after being diagnosed with this disease (< 5%). There is no approved cancer vaccine for pancreatic cancer, and the prognosis is very poor. The survival time of advanced patients is weeks or months. The disease is usually treated with the cytotoxic drug gemcitabine. However, this treatment seems to be mainly used for palliative treatment of advanced pancreatic cancer, which can improve the quality of life and prolong the median survival time of 5 weeks. Most patients will soon develop resistance to this drug. Therefore, the indomitable Professor steinman tried to use dendritic cell vaccine to treat his pancreatic cancer. Dendritic cells are the main antigen presenting cells (APC) in the immune system. They process antigenic substances (for example, from invading bacteria and viruses, and from cancer cells) and present antigens on their surfaces to other types of immune cells, especially T cells. This leads to antigen-specific activation of T cells. Therefore, dendritic cells act as the main link between innate immune system and adaptive immune system.　

02　　After eight treatments, dendritic cell vaccine made him live for four and a half years!

　 Professor steinman tried eight experimental therapies, one at a time. For each of these treatments, he and his colleagues submitted a single-patient use agreement to the FDA and obtained the approval of the agency. In these treatments, there are three kinds of cancer vaccines, and steinman finally used the dendritic cell vaccine from his own tumor instead of the cell line. Patients with advanced pancreatic cancer usually have poor prognosis. The median survival time of locally advanced and metastatic pancreatic cancer (advanced pancreatic cancer accounts for more than 80% of individuals diagnosed with the disease) is about 10 months and 6 months respectively. For all stages of pancreatic cancer, the 1-year and 5-year relative survival rates were 25% and 6%, respectively. However, Dr. steinman’s life span has been extended from several months to four and a half years! Since then, the medical community has launched a craze for the research and development of dendritic cell vaccines, which has become a kind of immunotherapy with more research and development achievements in recent years. At present, the dendritic cell vaccines approved by the FDA and many clinical trials entering the third phase are worth looking forward to. Since 2010, exceptThe FDA approved the first dendritic cell vaccine Provenge(sipuleucel-T) for the treatment of refractory prostate cancer. Dendritic cell vaccine has achieved good results in all kinds of cancer. Such as brain tumor-DC VAX-L vaccine, melanoma-—TLPLDC vaccine, renal cancer-—ilixadencel vaccine, newly diagnosed glioblastoma-AV-GBM-1 vaccine, lung cancer-CCL 21-dendritic vaccine, breast cancer -Her2 pulsed dendritic cell vaccine, etc.Xiaobian will not go into details here.

Nasopharyngeal Carcinoma: After 33 proton treatments, Li Zongwei successfully returned to badminton.

　 As the uncrowned king of badminton in the world, Li Zongwei, a famous Malaysian badminton player, has a brilliant career, with three runners-up in the Olympic Games, four runners-up in the World Championships, one runner-up in the soup cup and one silver medal in the men’s singles in the Asian Games. However, on July 25, 2018, he met another more powerful opponent-nasopharyngeal cancer. According to Malaysian media reports, Li Zongwei suddenly announced his withdrawal from the World Badminton Championships and the Asian Games badminton competition, and was later confirmed to have early nasopharyngeal carcinoma in September. However, Li Zongwei was not defeated by the disease. After 33 proton treatments of 25 minutes each time for more than two months, the doctor said that all the cancer cells in his body had been eliminated. In October of the same year, after he announced the success of anti-cancer, he said that he would return to badminton in December. Perhaps Li Zongwei is not a "winner" in badminton. Although he has won numerous titles, he has never won a world championship, including a slightly dismal record against Lin Dan. This time, however, in the face of this "competition" with the same disease, he finally won. This win will be the greatest capital of his life. In terms of treatment, it is difficult to perform radical surgery because of the special location and unclear boundary of nasopharyngeal carcinoma, the deep and narrow nasopharyngeal cavity, and many important blood vessels, cranial nerves and lymphoid tissues around it. But nasopharyngeal carcinoma is sensitive to radiotherapy, Therefore, radiotherapy is the main treatment for nasopharyngeal carcinoma, especially proton therapy. As the "king" of "precision radiotherapy", it can not only show its talents, but also effectively prevent the side effects of radiotherapy.

Proton therapy is a "qualitative leap" in tumor radiation!

　 Proton therapy is to accelerate the nucleus of hydrogen atom (i.e. proton) which has lost electrons to about 70% of the speed of light by using cyclotron or synchrotron. After being accelerated by the accelerator, protons with positive charges become very penetrating ionizing radiation, which enters the human body at a very high speed, is guided by special-shaped equipment, and finally reaches the targeted tumor site. Because of its high speed, the chance of interaction with normal tissues or cells in the body is extremely low. When it reaches a specific part of the tumor, the speed suddenly decreases and stops, and the maximum energy is released, resulting in a "Bragg peak", which can kill cancer cells without causing damage to surrounding tissues and organs.

　 　

When tumors are directly adjacent to important organs or structures, such as spinal cord, optic nerve and heart, proton therapy can still effectively treat tumors while protecting the functions of these important organs or structures, which is impossible in conventional radiation therapy.

　

The high radiation dose is concentrated in the tumor site, and there is no/little dose in the surrounding normal tissues.

　 　　

　

Legend: The radiation of Intensity Modulated Proton Therapy (IMPT) is mainly concentrated around the focus of nasopharyngeal carcinoma, with little or no influence on the surrounding normal tissues, while the radiation area of Intensity Modulated Radiotherapy (IMRT) is large, covering the focus and surrounding normal tissues.

Melanoma: "cured" after 4 months, immunotherapy made Carter the "longest-lived president"

　 In August 2015, former US President Carter was diagnosed with malignant melanoma, and liver metastasis and brain metastasis have occurred, so he is an out-and-out terminal patient. But just four months later, at an event in December, 91-year-old Carter announced that he had just confirmed after a general examination that the lesions in his body had disappeared. 　

It is understood that Carter used comprehensive therapy. First, the visible tumor was surgically removed, then the intracranial tumor was treated by radiotherapy, and finally the PD-1 drug Keytruda of Merck was used. After the brain cancer cells disappeared, Carter said that he would continue to use Keytruda for treatment. This incident made immunotherapy popular all over the world overnight. PD-1/PD-L1 and CTLA-4 pathways are crucial to the immune system’s ability to control cancer growth. These pathways are often called immune checkpoints. Many cancers will use these ways to escape the immune system. Specific antibodies to immune checkpoint inhibitors can block these pathways to deal with cancer. Once the immune system can find and deal with cancer, it can stop or slow down the development of cancer. Having said that, I have to mention the biggest difference between immunotherapy and traditional treatment, that is The trailing effect of immunotherapy, that is, patients who benefit from immunotherapy can continuously obtain stable results and bring long-term survival.

This article is original for a cancer-free home, and it needs authorization to reprint.

　　Huawei-related topics are always one of the hot spots in the industry.

　　Recently, a chat record involving the dystocia of the first model of the Zhijie brand, which Chery cooperated with Huawei, quickly circulated on the Internet and continued to ferment. In the chat record, a netizen suspected of being a Chery employee directly pointed the finger at Huawei for the dystocia of Zhijie S7, and revealed that "the leader who has been working hard to promote cooperation with Huawei directly resigned."

　　Subsequently, the leader was confirmed as Han Biwen, deputy general manager of Chery Automobile Co., Ltd. and general manager of the manufacturing division. However, on January 31, the reason for Wang Chuan’s departure was denied by Chery’s spokesperson Jin Yibo: the cooperation between the two parties was smooth, and they were making every effort to promote the production and delivery of Zhijie S7, and they had invested more resources and would continue to deepen cooperation.

　　But this response does not seem to be recognized by the public.

　　The intellectual S7 is "far ahead" and "far away"

　　After questioning, M7 went against the trend and returned to the mainstream market after its listing, which made its new cooperation project Zhijie Automobile become the focus of public attention. However, in 2024, the delivery of the new M7 four-wheel drive version, the delayed delivery of Aouita 12 and the dystocia of Zhijie S7 made Huawei’s new models collectively face the delivery problem.

　　For the first two, whether it is CMO Li Pengcheng, vice president and chief marketing officer of Aouita Science and Technology, or all the suppliers visited by Gaspar, it is attributed to the fact that the sales of products far exceeded expectations, resulting in insufficient supply. "At present, the production capacity is climbing, and the supply shortage will be alleviated as soon as possible in the past two weeks." A practitioner who supplies the new M7 precursor parts in the world revealed to Gaspar.

　　However, compared with the sweet burden of the new M7 and Aouita 12, the intellectual S7 is still shrouded in gloom.

　　On January 15th, Zhijie Automobile issued a document on its official account, saying that the factory is making every effort to produce and ensure high-quality delivery. This subsidy is mainly for users who have made a decision between November 28th, 2023 and January 15th, 2024. They can enjoy the subsidy after waiting for more than 6 weeks, and they can get a maximum subsidy of 10,000 yuan in 200 yuan every day.

　　Previously, there had been a lot of rumors on related forums and social platforms that Zhijie S7 was delayed in delivery and not delivered in order. Just one week after the release of the above compensation plan, Gaspar learned from the relevant sales staff that the official promised delivery time has been extended from 6 weeks to 10-12 weeks.

　　On November 28th, 2023, Huawei released the first pure electric car-Zhijie S7 under the smart car selection business model, which is the first product of Zhijie brand and the first model of cooperation between Huawei and Chery under the smart car selection business model.

　　According to the latest news, as of the end of December, the large quantity of Zhijie S7 has exceeded 10,000, and the number of offline stores has exceeded 100 in a single day. However, according to the terminal data of Geshi Automobile Research Institute, in December 2023, the cumulative sales volume of Zhijie S7 nationwide was only 305, and according to the staff of Zhijie Automobile’s delivery center in Shanghai, there was only one centralized delivery in December last year, and there were no new cars afterwards.

　　Obviously, it seems difficult to copy and paste it on Zhijie S7 due to excessive sales and insufficient production capacity. You know, compared with the manufacturing strength of Cyrus, the new "Intelligent Networked Super Factory No.2" built by Chery has a planned annual production capacity of 500,000 vehicles, which makes it hard to believe that Zhijie S7 will be difficult to produce.

　　In this regard, the senior analyst of Gaspar Automotive Research Institute believes that instead of the high centralization of Huawei in software, it is more inclined to the imbalance of production rhythm between the two parties after the release of new cars, the yield of supply chain parts in mass production of new technologies and the insufficient preparation of the production line of the automobile factory are all reasons for the delay in mass production of Zhijie S7.

　　The rumor that "Huawei has no basic respect for Chery" may not be groundless. Some insiders pointed out to Geshi Automobile that in the car-making business, Huawei really wants to dominate the whole process of new cars, but in cooperation with enterprises with scale advantages such as Chery and Changan, they also don’t want to be only supporting roles, and conflicts in product dominance and management styles and cultures of different companies are inevitable.

　　The success of asking the world may be difficult to replicate.

　　As we all know, with more than 30 years of profound accumulation in the ICT field, Huawei has cut into the car track in three modes: standardized parts suppliers, HI mode and HarmonyOS Zhixing, and the cooperation has gone from shallow to deep.

　　Among them, HI mode is provided by Huawei with full-stack smart car solutions such as intelligent cockpit, intelligent driving and intelligent Che Yun, such as the cooperation of BAIC Extreme Fox and Aouita brand; In addition to providing parts and solutions, HarmonyOS Zhixing will also fully participate in product design, brand building, sales channels and other aspects, such as the cooperation with Cyrus, and so on.

　　According to Yu Chengdong’s plan, Huawei’s automobile business unit (Car BU) plans to make a profit in 2025, so as to change the situation that "Car BU is Huawei’s only loss-making business". To achieve this goal, it is necessary to ensure that the cumulative sales volume of HarmonyOS Zhixing and HI mode reaches 1 million vehicles.

　　It is worth noting that according to the terminal data of Geshi Automobile Research Institute, in 2023, the cumulative sales volume including Aouita 11/12, Wenjie M5/M7/M9 and Zhijie S7 was only 114,000.

　　This means that Huawei BU must accelerate the pace of implementation this year. On January 16th, the day after HarmonyOS Zhixing implemented the compensation scheme of Zhijie S7, a wholly-owned new company, Huawei Car BU, was formally established. On the same day, the joint venture between Huawei and Changan also made new progress. Changan Automobile revealed that the new joint venture between Changan and Huawei was tentatively named "Newcool".

　　As for Yu Chengdong, Huawei will also cooperate with BAIC and JAC respectively in HarmonyOS Zhixing business after consulting with the intellectual community. The brand of cooperation between Huawei and BAIC HarmonyOS Zhixing mode is determined as "enjoying the world", and the first model is positioned as a medium and large car, which will be officially released before the Beijing Auto Show in April; The brand of HarmonyOS Zhixing, which cooperates with Jianghuai, is designated as "Aojie", and the first car will be released in Q4, 2024, which is a million-level product.

　　According to the latest news, as of January 28th, the cumulative sales volume of vehicles in the car industry in January has exceeded 28,000, setting a new record for the highest monthly sales volume. According to the data on January 9th, the cumulative delivery volume of the new M7 has reached 48,552 vehicles, and the cumulative sales volume has exceeded 120,000 vehicles. It is worth mentioning that, in addition to the new M7, the two models of the AITO series, the M5 and M9, have also received much attention. With the launch of mass delivery of the M9 and the launch of the new SUV model M8, it is expected to further promote the sales of the M 9 brand to a new high.

　　Therefore, to a certain extent, S7, the first model of Zhijie brand, has become the key to whether Huawei’s HarmonyOS Zhixing model can win the cooperation between car companies.

　　However, in the view of senior analysts of Gaspar Automotive Research Institute, the core sales source of HarmonyOS Zhixing model in the future will still be the contribution of the products that have cooperated with Cyrus, and it is also Huawei’s most "obedient" and recognized partner in this model, and the products of other enterprises may not have much sales performance. "The delay in the delivery of the intelligent S7 will inevitably affect the user’s car purchase choice, which in turn will affect the confidence of cooperation between the two parties."

　　Zhu Huarong, the chairman of Changan Automobile, who established a new joint venture with Huawei, is even more outspoken in his resistance to HarmonyOS Zhixing. He stressed that Changan must have its own brand and choose Hi mode because it conforms to the national industrial policy. The implication is that under the HarmonyOS Zhixing model, the division of labor between Huawei and car companies is unclear, which may lead to problems in the protection of rights and interests in the process of users using cars.

　　There is a clearer positioning, which is the insistence of Changan Automobile, and I believe it is not just the insistence of Changan Automobile.

　　In tHis context, the above analysts believe that hi mode will still have enterprises to adopt cooperation, especially domestic car companies, mainly to complement their intelligent shortcomings and learn from the organization and management of Huawei IPD. In addition, Huawei Car BU Yinwang Technology Co., Ltd. has a very large room for growth in the future by binding car companies to create an "ASML model" in the smart car ecosystem.

　　As mentioned earlier, Huawei’s circle of friends continues to expand rapidly. If all goes well, it is not out of reach to achieve the goal of one million vehicles in 2025. However, the success of the world of inquiry has not made all brands resolutely hand over the dominant position like Cyrus, and the constant disputes in the intellectual world have made Huawei’s future in the last three "circles" full of uncertainty. How to balance the needs and cooperation of different car companies may become a more critical focus of Huawei HarmonyOS Zhixing in the future than expansion. （Garcia）

　　German scientists have discovered a magical chameleon subspecies in northern Madagascar. They are only the size of melon seeds and can lie on human fingers, which may be the smallest reptile on the earth.

　　The Bavarian National Zoo in Munich, Germany, said that they found two adult miniature chameleons, a female and a male, in northern Madagascar. Among them, the male is only 22 mm long, which is the smallest known reptile. The other female chameleon is a little bigger, but the total length is only 29 mm.

　　The researchers said that it is not clear why the species is so small, but perhaps similar to the "island effect", animals trapped on the island and with small habitats tend to evolve smaller bodies.

　　However, the living environment of this new species is worrying. The habitat of this chameleon has been destroyed by deforestation. Fortunately, in recent years, the government has planned a protected area in the local area, so they are lucky to survive.

　　The key to building a socialist modern country in an all-round way and promoting the great rejuvenation of the Chinese nation lies in the party, the key lies in people, and in the final analysis, the generation after generation of loyal and reliable young cadres who can shoulder heavy responsibilities hold the "baton" in the new era. Recently, "Qiushi" magazine published an important article by the Supreme Leader General Secretary, "Strive to grow into a pillar talent who is loyal and reliable to the party and the people and worthy of the heavy responsibility of the times", focusing on major issues such as how young cadres grow into talents and who to start businesses for, and profoundly expounding from six aspects, and putting forward clear requirements for young cadres. As a Selected Graduates, I deeply feel the arduous responsibility and glorious mission, and I am also excited to have a broader grassroots world to display my talents, and I am more determined to grow into a new era Selected Graduates worthy of the heavy responsibility of national rejuvenation.

　　Build a solid foundation of belief that "politics is the first and loyalty is the most important".The party’s political construction is a fundamental, fundamental and overall issue concerning the direction, future and destiny of the party and the country. Talking about politics is the most basic and important standard and principle to measure a cadre. In the new era, Selected Graduates should take a clear-cut stand on politics, enhance its political position, strengthen its political responsibility, strive to improve its political judgment, political understanding and political execution, constantly temper its loyal and reliable political character to the party and the people, deeply understand the decisive significance of the "two establishment", constantly enhance its "four consciousnesses", strengthen its "four self-confidences", achieve its "two maintenance", and closely combine its personal ideal with Socialism with Chinese characteristics’s common ideal to achieve lofty ideals.

　　Practice the excellent skills of "solid theory and strong practice".Selected Graduates, from the campus to the society, from the organs to the grassroots, is unfamiliar with the actual situation of the village community and lacks experience in dealing with residents, so it is urgent to master the methods of mass work. It is necessary to strengthen theoretical study, strengthen theoretical foundation, and learn to observe, study and solve grassroots problems with the Party’s innovative theory. Consciously use the party’s innovative theory to guide practice and promote work, be good at summing up experience and grasping laws in grass-roots work and practice, and pay attention to strengthening tempering and increasing skills in peacetime work. Be willing to be a "primary school student", learn from the masses, strengthen investigation and research, and constantly improve comprehensive quality and work ability in dealing with various grassroots problems.

　　Always keep the enterprising attitude of "starting a business and bravely shouldering heavy burdens".As an outstanding representative of young people, Selected Graduates should take the initiative to do something, not despise trivial matters at the grass-roots level, not be afraid to avoid major events and difficulties related to development, be brave in "volunteering", dare to "ask for trouble" and get rid of "being superior to others"; We must be brave enough to take on heavy tasks, dare to wade through dangerous beaches, rapids and reefs, take the initiative to fight for the heaviest burden, gnaw at the hardest bones, and practice "hard and wide shoulders" in pioneering and forging ahead; We should do good deeds and make achievements, establish the value orientation of "reactive power is excessive, mediocrity is wrong", resolutely attack perfunctory and confused work, make everything closed-loop and effective, strive to grow into a "sharp soldier" who can do things, know how to do things and get things done, and contribute Selected Graduates’s strength to writing the grass-roots chapters of Chinese modernization. (Author: Xue Cheng)

When our career is stable and our income is gradually "well-off", our originally poor life has also changed a lot, and the car we once yearned for is no longer out of reach. The late car cost of plug-in hybrid is the point that its potential consumers pay more attention to. Let’s look down with Xiaobian.

Let’s take a look at the appearance of the Volvo XC60 plug-in hybrid. The Volvo XC60 plug-in hybrid front is avant-garde and looks more delicate. Headlights are very avant-garde, and the overall look has a certain sense of hierarchy. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, automatic steering, delayed closing and so on. Coming to the side of the car body, the size of the car body is 4708 mm * 1902 mm * 1656 mm. The car adopts sharp lines, and the side gives a very tough feeling. With large-sized thick-walled tires, smooth lines run through the whole side of the car. In the design of the rear end, the rear end looks more capable, and the taillights give people a very sharp feeling, and the shape is relatively hard.

Sitting in the car, the Volvo XC60 plug-in hybrid interior looks very comfortable, and the overall visual effect is very distinctive. The steering wheel of the car is very cute, made of leather, and the shape is very fighting. Take a look at the central control, with a 9-inch touch-sensitive LCD central control screen, which makes the interior style impressive and gives people a sense of simplicity and generosity. Finally, let’s take a look at the dashboard and seats. The car is equipped with a stylish dashboard with a sense of technology. The car adopts leather seats, and is equipped with functions such as electric adjustment with memory in the auxiliary seat, electric adjustment with memory in the seat, and seat proportion tilting, which further improves the comfort of the driver and passenger.

Next, look at the configuration. Volvo XC60 plug-in hybrid is equipped with car networking, driving mode selection, remote control key, rear wiper, traction control (ASR/TCS, etc.) and other configurations.

The moderate size of the car is a very suitable choice for many families, and the internal space is enough for daily use in families. As long as you really like it, it’s over. Go to the 4S shop and place an order.

　　People’s Daily Online, Beijing, May 13 (Yang Xi) Recently, the release of the main data of the seventh national census has aroused great concern from all walks of life. Some netizens found that the trend reflected by the census data published this time is inconsistent with that published in non-census years, so they raised some questions about individual data.

　　In this regard, the National Bureau of Statistics answered the above questions and related questions of population statistics.

　　How to count and publish population data?

　　At present, China’s demographic survey mainly has three ways:

　　The first is the national census, which is conducted once every ten years in the year when the mantissa meets "0", and the census data is published in China Census Data.

　　The second is the national 1% population sampling survey, which was conducted in the year when the mantissa met "5", and the survey data was published in the National 1% Population Sampling Survey Data.

　　Third, the national sample survey of population changes, the sample size accounts for about 1&permil of the total population; In addition to the census year and the sampling year of 1% population survey, it is conducted once a year, and the survey data are published in the Statistical Yearbook of China and the Statistical Yearbook of Population and Employment of China.

　　The main statistical indicators of the above three types of population data will be published in the annual data in the database of the National Bureau of Statistics.

　　Why is the trend reflected by census data inconsistent with that published in non-census years?

　　The population in non-census years is calculated according to the sampling survey data of that year. Due to the missing rate of sampling surveys in some years, there will be some deviations in the estimated population as a whole, and these deviations will continue to accumulate with the passage of time.

　　Carrying out the population census once every 10 years can comprehensively find out the number, structure and distribution of China’s population, let us know more clearly the development of China’s population in the past 10 years, and provide extremely valuable data for better studying population issues and formulating population-related policies.

　　So how to deal with this inconsistency? According to international practice and common practice, after the census, the annual data published between the two censuses are generally revised according to the census results, so as to reflect the population development track more truly and objectively. In the sixth national census and the just-concluded fourth national economic census, historical data were also revised according to census data. At present, this work is in progress, and the relevant data will be released on schedule after the revision is completed.

　　Is the population statistics based on household registration or residence?

　　At present, China’s population census and population survey are counted and summarized according to the resident population. The time standard for judging the permanent population is half a year, and the space standard is township, town and street.

　　The resident population is an important basic data for formulating the national economic and social development plan, evaluating the national economic production capacity, and evaluating the welfare level of residents. It has a wide range of applications, such as financial expenditure, urban construction, housing construction, allocation of public facilities, education investment, medical investment and public utility investment, etc., which need to be planned according to the size of the resident population.

　　The registered population refers to the registered population in a certain area, regardless of whether they go out or not, as long as they register their permanent residence in the public security household registration management department. The data of registered population is counted by the public security department. For a long time, China has established a set of perfect household registration statistics and management system, which has played an important role in social management.

　　How is the floating population data counted?

　　Floating population refers to the population whose residence is inconsistent with the township street where the household registration place is located, and who has been separated from the household registration place for half a year or more (excluding the separation of households within the municipal area). The survey indicators used to judge and reflect the floating population include: the place of registration, the place of residence at the time of investigation, the time of leaving the place of registration and the reasons for leaving the place of registration. The National Bureau of Statistics formulates a demographic survey system according to the Statistics Law of the People’s Republic of China, conducts demographic surveys on a regular basis, and publishes major demographic data such as permanent population, birth population, dead population, urban and rural population and floating population.

　　Cctv newsOn December 25th, snow or sleet occurred in central and southern Shaanxi, southwestern Shanxi, Henan, western Shandong, western Hubei and other places, with the cumulative precipitation of 1-5 mm and local area of 6-10 mm in central Shaanxi.

　　Affected by cold air, this morning, the temperature dropped by 6 ~ 8℃ in eastern and southern Qinghai, eastern Gansu, Ningxia, Shaanxi, northwestern Shanxi, central Inner Mongolia, southeastern Heilongjiang and central and eastern Jilin, with a local drop of 10 ~ 12℃. It is estimated that in the next three days, the temperature will drop by 4~6℃ in the eastern part of Northwest China, the central and eastern Inner Mongolia, the western part of North China and the eastern part of Southwest China, and the local temperature drop can reach more than 8℃. There are 4~5 winds and gusts of 6~8 in some areas mentioned above.

　　It is expected that there will be a rainy and snowy weather process in the southern region from the night of today to the 29th. There will be small to medium snow or sleet in eastern Tibet, northern Yunnan, western Sichuan Plateau, southeastern Chongqing, Guizhou, western Hunan, western Hubei, southern Anhui, northwestern Zhejiang and other places, heavy snow in central and eastern Guizhou and western Hunan, and freezing rain in western Guizhou. There are light rains in Sichuan Basin, south-central Yunnan, southern Hunan, most of Jiangxi, most of Zhejiang, northern Fujian, Guangxi and northern Guangdong, and local rains; The main precipitation period is from 27th to 28th.

　　In addition, there will be light snow in eastern Inner Mongolia, Heilongjiang and northern Jilin tomorrow and tomorrow.

　　Meteorologists reminded that there are still strong winds and cool weather in the northern region affected by cold air activities, and the public needs to take protective and warm measures; There will be rain and snow in many places in the south, and public travel needs to guard against the adverse effects of slippery roads and reduced visibility.