Cancer is a big problem in the history of human medicine, and there is no way to completely cure it at present. In the face of cancer with extremely high mortality, life is fragile. No matter whether it is poor or rich, famous or unknown, we often see the news that celebrities have died of cancer, and we can’t help sighing, but there are also some wonderful experiences of anti-cancer success!　 Many cancer patients often lose confidence in life after learning that they have cancer, do not actively treat them, or even resist treatment, and feel that treatment is unnecessary, and treatment is a waste of money. In fact, this idea is not correct. Don’t give up until the last moment. Even if cancer has not been completely overcome, after scientific and reasonable treatment with many patients, life can be continued, and even clinical cure or long-term survival with tumors can be achieved! Nowadays, there are many treatments for cancer. If it is found as early as possible and treated actively, one third of cancer can be cured. Medical "cure" is different from what people usually understand. The clinical cure here refers to the disappearance of symptoms and signs after treatment, and the tumor can not be found after image review for more than 5 years.

Today, Xiaobian, a cancer-free home, will share the stories of four celebrities who have succeeded in fighting cancer, and see how they fight cancer. I hope to give some reference and motivation to all cancer friends!

Kai-Fu Lee: From the late stage of cancer to the disappearance of tumor, chemotherapy+targeted therapy against advanced lymphoma.

　 On September 5th, 2013, 52-year-old Kai-fu Lee, the founder of Innovation Factory, announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from. 　

Lymphoma, also known as lymphoma, occurs in the lymphatic system and is one of the malignant diseases of the blood system. In fact, we are no strangers. Besides Kai-Fu Lee, celebrities such as Luo Jing, Asan and Cindy Lee have also suffered from lymphoma. The incidence of lymphoma is actually not too high in malignant tumors, which is about 5/100,000. It can occur at any age, but it is mainly in middle-aged people aged 30-50. The malignant degree of different types of lymphoma varies greatly, which can be roughly divided into: inertia, aggression and high aggression. Inertial lymphoma is similar to chronic diseases, while high aggression is like a "death warrant"! There are many types of lymphoma, but as long as we know, lymphoma can be divided into Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL), the latter accounting for about 90%, and diffuse large B-cell lymphoma is the main type (40%~50%). When you know that you have stage 4 or systemic metastasis, it doesn’t mean that your condition is very serious and there is no cure. Don’t give up treatment easily. The treatment of lymphoma is mainly systemic chemotherapy and radiotherapy. Li Kaifu’s treatment plan is that bendamustine (bendamustine) is combined with rituximab (rituximab, trade name: rituximab). Different from traditional chemotherapy drugs, rituximab is called "an artifact to accurately combat lymphoma". It is an anti-CD20 monoclonal antibody against malignant B lymphocytes, with good effect and little side effects, and it is a milestone in the treatment of lymphoma. 　

Since rituximab was listed in the United States in 1999, the 5-year survival rate of patients with diffuse large B-cell lymphoma has increased to 50%. Rituximab used to be a self-funded drug, which was expensive. Now it has been included in the scope of medical insurance reimbursement, which has enabled many cancer friends to enjoy the fruits of modern medical progress.　　

In addition, Kai-Fu Lee also tried many kinds.Natural therapyIn order to finally defeat cancer.

Keeping a good sleep is the most important thing. Staying up late for a long time may reduce the body’s immunity, and his lymphoma is a common cancer in the immune system. Therefore, after suffering from cancer, he made a schedule to protect his immunity. It is necessary to keep your mouth shut when disaster comes from your mouth. It is particularly important for cancer patients to keep their mouths shut, and maintaining good eating habits can better fight cancer. Kai-fu Lee suggested that everyone should eat more grains, beans, fruits and vegetables, and take a balanced intake. 3. Take your legs apart and exercise properly to inhibit cancer cells. Many studies have confirmed that exercise is beneficial to the rehabilitation of cancer patients and can reduce the risk of cancer recurrence after operation. However, it should be reminded that not all exercise is suitable for cancer patients, and it is suggested to use the principle of "not feeling tired". 4. Good attitude, get twice the result with half the effort When fighting cancer, it is very important to keep a good attitude, which has a great influence on cancer treatment.

Pancreatic cancer: steinman "tried medicine by himself", and the dendritic cell vaccine made him live for four and a half years!

　 Speaking of vaccines, everyone is actually familiar with them, except for the common hepatitis B vaccine and influenza vaccine, and the Covid-19 vaccine that we have vaccinated up to now. In fact, cancer vaccine is also a form of immunotherapy, which can prevent cancer from developing or kill existing tumors by stimulating or restoring the human immune system. In the 21st century, the high incidence of cancer has attracted the attention of the global medical community. As a prominent tumor vaccine, dendritic cell vaccine has been a research hotspot in this field. When it comes to dendritic cell vaccine, we have to mention a legendary figure-ralph steinman, winner of the 2011 Nobel Prize in Physiology or Medicine. 　　

ralph marvin steinman After the diagnosis of pancreatic cancer in 2007, steinman actively tried a therapeutic vaccine (DC vaccine) based on dendritic cells. With the help of this "cellular immunotherapy", his life was extended from the expected months to four and a half years.　 There is a rule in the Nobel Prize that they never give this prize to people who have passed away. However, ralph steinman broke this rule because he passed away quietly three days before receiving the call for winning the prize. Therefore, Staman is also called the most regrettable Nobel Prize winner.

　 0one　　Suffering from pancreatic cancer with a mortality rate of 95%, he devoted himself to the research of DC vaccine.

In 1973, steinman discovered dendritic cells in the spleen of mice, and put forward the concept of dendritic cells. In 2011, steinman shared the Nobel Prize in Physiology or Medicine with Jules Hoffman and Bruce Beutler for "discovering dendritic cells and their role in the acquired immune system".

Pancreatic cancer, which claimed steinman’s life, is one of the malignant tumors with the highest mortality rate at present. The mortality rate of this disease can reach 95% clinically, and it is very rare for patients who can survive for 5 years after being diagnosed with this disease (< 5%). There is no approved cancer vaccine for pancreatic cancer, and the prognosis is very poor. The survival time of advanced patients is weeks or months. The disease is usually treated with the cytotoxic drug gemcitabine. However, this treatment seems to be mainly used for palliative treatment of advanced pancreatic cancer, which can improve the quality of life and prolong the median survival time of 5 weeks. Most patients will soon develop resistance to this drug. Therefore, the indomitable Professor steinman tried to use dendritic cell vaccine to treat his pancreatic cancer. Dendritic cells are the main antigen presenting cells (APC) in the immune system. They process antigenic substances (for example, from invading bacteria and viruses, and from cancer cells) and present antigens on their surfaces to other types of immune cells, especially T cells. This leads to antigen-specific activation of T cells. Therefore, dendritic cells act as the main link between innate immune system and adaptive immune system.　

02　　After eight treatments, dendritic cell vaccine made him live for four and a half years!

　 Professor steinman tried eight experimental therapies, one at a time. For each of these treatments, he and his colleagues submitted a single-patient use agreement to the FDA and obtained the approval of the agency. In these treatments, there are three kinds of cancer vaccines, and steinman finally used the dendritic cell vaccine from his own tumor instead of the cell line. Patients with advanced pancreatic cancer usually have poor prognosis. The median survival time of locally advanced and metastatic pancreatic cancer (advanced pancreatic cancer accounts for more than 80% of individuals diagnosed with the disease) is about 10 months and 6 months respectively. For all stages of pancreatic cancer, the 1-year and 5-year relative survival rates were 25% and 6%, respectively. However, Dr. steinman’s life span has been extended from several months to four and a half years! Since then, the medical community has launched a craze for the research and development of dendritic cell vaccines, which has become a kind of immunotherapy with more research and development achievements in recent years. At present, the dendritic cell vaccines approved by the FDA and many clinical trials entering the third phase are worth looking forward to. Since 2010, exceptThe FDA approved the first dendritic cell vaccine Provenge(sipuleucel-T) for the treatment of refractory prostate cancer. Dendritic cell vaccine has achieved good results in all kinds of cancer. Such as brain tumor-DC VAX-L vaccine, melanoma-—TLPLDC vaccine, renal cancer-—ilixadencel vaccine, newly diagnosed glioblastoma-AV-GBM-1 vaccine, lung cancer-CCL 21-dendritic vaccine, breast cancer -Her2 pulsed dendritic cell vaccine, etc.Xiaobian will not go into details here.

Nasopharyngeal Carcinoma: After 33 proton treatments, Li Zongwei successfully returned to badminton.

　 As the uncrowned king of badminton in the world, Li Zongwei, a famous Malaysian badminton player, has a brilliant career, with three runners-up in the Olympic Games, four runners-up in the World Championships, one runner-up in the soup cup and one silver medal in the men’s singles in the Asian Games. However, on July 25, 2018, he met another more powerful opponent-nasopharyngeal cancer. According to Malaysian media reports, Li Zongwei suddenly announced his withdrawal from the World Badminton Championships and the Asian Games badminton competition, and was later confirmed to have early nasopharyngeal carcinoma in September. However, Li Zongwei was not defeated by the disease. After 33 proton treatments of 25 minutes each time for more than two months, the doctor said that all the cancer cells in his body had been eliminated. In October of the same year, after he announced the success of anti-cancer, he said that he would return to badminton in December. Perhaps Li Zongwei is not a "winner" in badminton. Although he has won numerous titles, he has never won a world championship, including a slightly dismal record against Lin Dan. This time, however, in the face of this "competition" with the same disease, he finally won. This win will be the greatest capital of his life. In terms of treatment, it is difficult to perform radical surgery because of the special location and unclear boundary of nasopharyngeal carcinoma, the deep and narrow nasopharyngeal cavity, and many important blood vessels, cranial nerves and lymphoid tissues around it. But nasopharyngeal carcinoma is sensitive to radiotherapy, Therefore, radiotherapy is the main treatment for nasopharyngeal carcinoma, especially proton therapy. As the "king" of "precision radiotherapy", it can not only show its talents, but also effectively prevent the side effects of radiotherapy.

Proton therapy is a "qualitative leap" in tumor radiation!

　 Proton therapy is to accelerate the nucleus of hydrogen atom (i.e. proton) which has lost electrons to about 70% of the speed of light by using cyclotron or synchrotron. After being accelerated by the accelerator, protons with positive charges become very penetrating ionizing radiation, which enters the human body at a very high speed, is guided by special-shaped equipment, and finally reaches the targeted tumor site. Because of its high speed, the chance of interaction with normal tissues or cells in the body is extremely low. When it reaches a specific part of the tumor, the speed suddenly decreases and stops, and the maximum energy is released, resulting in a "Bragg peak", which can kill cancer cells without causing damage to surrounding tissues and organs.

　 　

When tumors are directly adjacent to important organs or structures, such as spinal cord, optic nerve and heart, proton therapy can still effectively treat tumors while protecting the functions of these important organs or structures, which is impossible in conventional radiation therapy.

　

The high radiation dose is concentrated in the tumor site, and there is no/little dose in the surrounding normal tissues.

　 　　

　

Legend: The radiation of Intensity Modulated Proton Therapy (IMPT) is mainly concentrated around the focus of nasopharyngeal carcinoma, with little or no influence on the surrounding normal tissues, while the radiation area of Intensity Modulated Radiotherapy (IMRT) is large, covering the focus and surrounding normal tissues.

Melanoma: "cured" after 4 months, immunotherapy made Carter the "longest-lived president"

　 In August 2015, former US President Carter was diagnosed with malignant melanoma, and liver metastasis and brain metastasis have occurred, so he is an out-and-out terminal patient. But just four months later, at an event in December, 91-year-old Carter announced that he had just confirmed after a general examination that the lesions in his body had disappeared. 　

It is understood that Carter used comprehensive therapy. First, the visible tumor was surgically removed, then the intracranial tumor was treated by radiotherapy, and finally the PD-1 drug Keytruda of Merck was used. After the brain cancer cells disappeared, Carter said that he would continue to use Keytruda for treatment. This incident made immunotherapy popular all over the world overnight. PD-1/PD-L1 and CTLA-4 pathways are crucial to the immune system’s ability to control cancer growth. These pathways are often called immune checkpoints. Many cancers will use these ways to escape the immune system. Specific antibodies to immune checkpoint inhibitors can block these pathways to deal with cancer. Once the immune system can find and deal with cancer, it can stop or slow down the development of cancer. Having said that, I have to mention the biggest difference between immunotherapy and traditional treatment, that is The trailing effect of immunotherapy, that is, patients who benefit from immunotherapy can continuously obtain stable results and bring long-term survival.

This article is original for a cancer-free home, and it needs authorization to reprint.

On October 29th, China Meteorological Bureau held a press conference in November 2024. At the meeting, Xiong Shaoyuan, member of the party group and deputy director of China Meteorological Bureau, introduced the main progress in the modernization of meteorological social services.

Xiong Shaoyuan, member of the Party Group and Deputy Director of China Meteorological Bureau, Zhang Aoguang Photography

In terms of ensuring safety, Xiong Shaoyuan said that China Meteorological Bureau adhered to the principle of putting people first and life first, actively integrated into the national emergency framework, and effectively built the first line of defense for meteorological disaster prevention and mitigation.

According to reports, in terms of emergency linkage mechanism with meteorological disaster warning as the guide, the progressive meteorological service mechanism has achieved national coverage, and a high-level early warning "calling" system has been established and improved. Since 2023, the cumulative number of party and government leaders at all levels and flood control has reached 580,000.

In terms of meteorological disaster risk early warning capability, the first national comprehensive risk survey of natural disasters was completed in 10 categories, and 45 meteorological disaster risk products were released daily. The accuracy of rainstorm warning signal has been improved to 93%, the early warning time of severe convective weather has reached 43 minutes, and the meteorological warning information can be delivered to the public in 3 to 8 minutes, with a coverage rate of 98.8%. In the past five years, the number of deaths caused by meteorological disasters has decreased by an average of 48.5% compared with that between 2014 and 2018, and the proportion of economic losses to GDP has decreased by an average of 0.15%.

In terms of weather modification ability, in the past five years, 5,547 aircraft operations and more than 227,000 ground operations have been organized, with an average annual increase of over 38 billion tons of precipitation, an area affected by artificial precipitation (snow) reaching 5 million square kilometers, and an area protected by artificial hail suppression reaching 600,000 square kilometers.

In terms of high-quality and efficient development, Xiong Shaoyuan said that China Meteorological Bureau adheres to the "big service concept" and meteorological services cover more than 70 industries in the national economy. Focusing on food security, the Ministry of Agriculture and Rural Affairs jointly issued 12 types of agro-meteorological disaster risk warnings. This year, according to the dry-hot wind warning, various localities adopted measures such as "one spray and three defenses" to help winter wheat reduce disasters and increase income by about 3 billion Jin. Focusing on ensuring smooth traffic, the Ministry of Public Security and the Ministry of Transport jointly created a new mode of "one road, three parties" linkage control. The number of traffic accidents caused by bad weather decreased by 50% year-on-year and the operational efficiency increased by 42%. Focusing on helping the development of new quality productivity, 59 meteorological high-value data products were listed on the data exchange. Explore the "meteorology × finance" service, initially build the meteorological service for risk reduction before the disaster, release the first batch of 69 financial meteorological indexes, and establish the financial meteorological index service platform.

(Original title: China Meteorological Bureau: The accuracy of rainstorm warning signal has increased to 93%, and meteorological warning information can be delivered to the public in 3 to 8 minutes)

(Source: Red Star News Author: Hu Yiwen Editor: Guo Manru)

　　During the half year of staying at home, have you tried your best for your child’s growth? Bone soup, growth hormone, nutritional supplement, stretching exercise &hellip; &hellip; Anyone who hears a folk prescription that can be shot up will give it to his own baby to try. However, are these so-called height-increasing tips really helpful for growing taller? Today, let’s take a look at the rumors of the height that are all the rage, and see if you have encountered the following "pits".

　　Rumor, drinking more bone soup can make you taller.

　　Bone is indeed rich in calcium, but it has little to do with calcium supplementation.

　　First of all, calcium in bones is difficult for human body to absorb; Secondly, no matter how long the bones are stewed, the calcium is difficult to dissolve into the soup. We see that the thick white soup is actually mostly fat. Therefore, drinking bone soup for a long time can not only supplement calcium, but also lead to the risk of obesity.

　　Compare the calcium content of bone soup and milk &mdash; &mdash; Bone soup: 2 mg/100 ml; Milk: 104mg/100ml.

　　The calcium content of milk is far greater than that of bone soup, so it is not as practical as drinking milk to supplement calcium for children and drink bone soup.

　　Rumours: Milk can grow taller when drunk in water.

　　The latest Dietary Guidelines for China Residents (2016) should drink 1,500-1,700 ml of water every day.

　　Protein and fat in milk are about 3%, sugar content is about 5% and calcium content is about 1%. If you drink milk according to this amount, the supply of calcium will be excessive, and the fat and energy will be much higher. Even if you drink half the milk you drink every day &mdash; &mdash; 800 ml, intake of fat and energy.

　　In addition, drinking milk as water will lead to excessive intake of protein in the body. Too much protein supply, the human body can’t "take it all", but the absorption rate will drop.

　　The daily consumption of milk should not exceed 500ml. Moreover, drinks such as fruit juice, carbonated drinks, functional drinks, AD calcium milk and other milk drinks should not be drunk, let alone used as daily water.

　　Rumours that Tianqi soup can grow taller.

　　In recent years, "Tianqi" has been sought after by many health people, and the fact that Tianqi can help children grow taller has become a concern of parents. At present, there is no scientific evidence to prove that the folk remedies of "Tianqi stewed chicken, Tianqi stewed ribs and Haima stewed Tianqi" can be safely and effectively increased. Moreover, these traditional Chinese medicines and tonics may have the risk of accelerating the closure of the epiphyseal line, which will lead to lifelong high damage and even endocrine diseases such as precocious puberty!

　　At the same time, herbal tea with Chinese herbal medicines is not suitable for children to drink more and often. Some nutrients fortified in packaged foods, such as milk and yogurt fortified with vitamin ad and calcium, and beverages fortified with vitamin C, iron and zinc, such as electrolyte drinks such as red bull, candy, bread, eggs, etc., should also look at the content when choosing, and calculate the need, otherwise it will go too far.

　　In addition, there are adult-formulated health care products such as pollen and royal jelly, which are also very risky for children to eat.

　　There was a five-year-old girl who ate pollen and royal jelly for several months in a row. Instead of growing taller, her breasts began to increase and her bone age reached nine years old. Children with precocious puberty will not be "superior", but will lead to early healing of epiphyses, and eventually lose the space for growing up and become "dwarfs".

　　Blame rumors and eat growth factors to grow taller.

　　Malnutrition does affect height, but the nutrients that are very easy to get in natural foods really don’t need to be supplemented with supplements. When you get some nutrition through natural food, you can also get many other nutrients that can promote growth. In recent years, various growth factors with lysine as the main component have become new nutritional supplements. It is said that eating it can promote healthy growth, calcium absorption, appetite and so on.

　　Lysine is an essential amino acid for human body. Like other amino acids, it can be obtained through daily diet. The statement that manufacturers sell lysine supplements is nothing more than that the lysine content in grains is very low, which can not meet the needs of human body.

　　We Asians’ traditional staple food rice does lack lysine, but there are many other foods rich in lysine to choose from, such as lean beef, pork, chicken, fish, shrimp, nuts, eggs, beans and legumes.

　　Instead of blindly buying expensive nutritional supplements, it is better to think of ways to give children these foods mentioned above.

　　Dispelling rumors and eating nutritional supplements are beneficial to development.

　　It is unnecessary for most parents to give their children supplements, such as vitamin C, calcium, zinc, etc., which are very easy to get from food. If the child’s long-term uneven diet has caused a serious lack of certain nutrients and caused diseases such as anemia and vitamin D deficiency rickets, it must be supplemented according to the doctor’s advice. Other conditions, including mild nutritional deficiency, can be supplemented by dietary adjustment, and should also be supplemented by dietary adjustment.

　　Slight nutritional deficiency can be slowly improved by dietary adjustment. For children themselves, life has not passed for a few years, and it is easy to improve through diet adjustment without the conditions of "long-term" lack.

　　Short-term and slight nutritional deficiency will not cause any problems. On the contrary, it may be because of parents’ efforts to develop good eating habits for their children and form a balanced diet structure, so that children can benefit for life.

　　Dietary supplement is the safest and most effective method.

　　Myth: Stretching and draping can grow taller.

　　For patients with hunchback and scoliosis, spinal traction can also help restore a certain height.

　　See it clearly? Recover!

　　To put it simply, after stretching exercise for a period of time, the interosseous tissue returns to a better thickness, and the measured height value will increase a little. However, such stretching is not the height of the child’s own long bone growth. If it is not stretched properly, it will easily cause muscle damage to the child.

　　I would like to remind everyone here that reasonable exercise is conducive to balancing the growth of bones and the metabolism of calcium and phosphorus in the whole body, and promoting the physical development of children. Pay attention to the exercise that can make the bone bear pressure, which is the best stimulus to promote bone growth.

　　I recommend the following sports:

　　● Including skipping rope and running, which is beneficial to the movement of limbs;

　　● Sit-ups, gymnastics and other sports that contribute to bone growth;

　　● Volleyball, badminton, swimming and other comprehensive sports all contribute to the growth and extension of the whole body bones.

　　However, it is particularly important to emphasize that we must stretch well to avoid the damage of joint ligaments. If children want to really grow up healthily, it is a better choice to exercise continuously for at least 4 to 5 days and ask for 30 to 45 minutes at a time. In addition, let children choose sports according to their age and interests, and carry out physical exercise under the premise of safety, which must be gradual. Text/Pan Hui (Peking Union Medical College Hospital)

　　German scientists have discovered a magical chameleon subspecies in northern Madagascar. They are only the size of melon seeds and can lie on human fingers, which may be the smallest reptile on the earth.

　　The Bavarian National Zoo in Munich, Germany, said that they found two adult miniature chameleons, a female and a male, in northern Madagascar. Among them, the male is only 22 mm long, which is the smallest known reptile. The other female chameleon is a little bigger, but the total length is only 29 mm.

　　The researchers said that it is not clear why the species is so small, but perhaps similar to the "island effect", animals trapped on the island and with small habitats tend to evolve smaller bodies.

　　However, the living environment of this new species is worrying. The habitat of this chameleon has been destroyed by deforestation. Fortunately, in recent years, the government has planned a protected area in the local area, so they are lucky to survive.

　　Huang Qiang, male, Han nationality, born in April 1963 in Dongyang, Zhejiang Province, joined the work in July 1983 and joined the Communist Party of China (CPC) in June 1985. He graduated from the School of Management of Northwestern Polytechnical University with a master’s degree, a doctor of engineering and a researcher-level senior engineer.

　　1979.09&mdash; 1983.07 majoring in aeronautical electrical engineering, Department of Aviation Automatic Control, Northwestern Polytechnical University

　　1983.07&mdash; 1987.09 Designer, Room 14, No.603 Institute of Aviation Industry

　　1987.09&mdash; In March 1990, he studied aviation electrical engineering in the Department of Aviation Automatic Control of Northwestern Polytechnical University and obtained a master’s degree in engineering.

　　1990.03&mdash; 1992.12 Engineer, deputy head and deputy director of the ad hoc system design room of the Engineering Development Department of Xi ‘an Aircraft Industry Company, Ministry of Aerospace.

　　1992.12&mdash; 1994.10 Director of the Ad Hoc System Design Office of the Ministry of Aerospace and Aviation Industry Corporation No.603 (during this period: 1994.03&mdash; In August 1994, China Aviation Technology Import and Export Shenzhen Company took a post exercise)

　　1994.10&mdash; April 2000 Assistant Director and Deputy Director of No.603 Institute of China Aviation Industry Corporation and General Manager and Executive Deputy Director of Science and Technology Industry Corporation (during this period: February 1998.02&mdash; 1998.06 Studying in English Training Class of Xi ‘an Foreign Languages Institute; 1999.03&mdash; 1999.07 Central Party School’s prefectural-level cadre training class)

　　2000.04&mdash; 2003.04 Director of No.603 Institute of China Aviation Industry First Group Corporation

　　2003.04&mdash; 2003.06 Head of the Preparatory Team of the First Aircraft Design and Research Institute of China Aviation Industry Corporation I.

　　2003.06&mdash; 2005.06 Dean, Deputy Secretary of the Party Committee and Director of Shanghai Aircraft Design Institute of China Aviation Industry Corporation I.

　　2005.06&mdash; 2006.01 Dean and Party Secretary of the First Aircraft Design and Research Institute of China Aviation Industry Corporation I and Director and Party Secretary of Shanghai Aircraft Design and Research Institute.

　　2006.01&mdash; 2008.06 Secretary-General of the Commission of Science, Technology and Industry for National Defense (2003.09&mdash; In June 2006, the School of Management of Northwestern Polytechnical University studied as an in-service postgraduate majoring in management science and engineering, and obtained a doctorate in engineering; 2007.03&mdash; 2008.01 Central Party School one-year training course for young and middle-aged cadres)

　　2008.06&mdash; 2014.01 Deputy Director and Member of the Party Group of the State Bureau of Science, Technology and Industry for National Defense

　　2014.01&mdash; 2017.03 Vice Governor of Gansu Province and Member of the Party Group of the Provincial Government

　　2017.03&mdash; 2018.05 Standing Committee of Gansu Provincial Party Committee, Executive Vice Governor and Deputy Secretary of the Party Group of the Provincial Government

　　2018.05&mdash; 2018.06 Standing Committee of Henan Provincial Committee

　　2018.06&mdash; 2020.11 Member of the Standing Committee of Henan Provincial Party Committee, Executive Vice Governor and Deputy Secretary of the Party Group of the Provincial Government

　　2020.11&mdash; 2020.12 Deputy Secretary of Sichuan Provincial Committee

　　2020.12&mdash; 2021.02 Deputy Secretary of Sichuan Provincial Party Committee, Vice Governor, Acting Governor and Party Secretary of the provincial government.

　　2021.02&mdash; Deputy Secretary of Sichuan Provincial Party Committee, Governor of Provincial Government and Party Secretary

　　Deputies to the 13th National People’s Congress and the 13th Provincial People’s Congress.

　　(Resume source: Sichuan Provincial People’s Government Network)

　　"It only takes a few lines of code to build a regression model." Programmers recognize the performance of Google AutoML and think that the model designed by AutoML is comparable to that designed by machine learning experts. A few days ago, Google engineers introduced the Google AutoML project in China and Silicon Valley respectively.

　　Confused doubts followed &mdash; &mdash; AI evolved again? ! Already self-developed? Can control their own evolution? Is it to get rid of humans?

　　How many steps does evolution take?

　　AI has indeed evolved, and it can do more and more things and achieve remarkable results. Behind it is the "triple jump" of AI implementation path &mdash; &mdash;

　　Zhao Zhigang, a researcher at the Big Data R&D Department of Jinan Center of National Supercomputing, said: "At first, we used mathematical formulas and &lsquo; if&hellip; &hellip; then&rsquo; Wait for the statement to tell the computer what to do in the first step and what to do in the second step, teach it by hand, and then give the machine N groups of inputs and outputs. The rules or laws in the middle are learned by itself. "

　　"Before, many smart minds spent their whole lives studying how to extract effective features." Mo Yu, CTO of Smart Point, which focuses on intelligent shopping guide dialogue robots, explained, "The invention of neural network algorithm and the emergence of deep learning technology have made AI evolve to 2.0, and the work of extracting features is carried out by AI itself, and our work has also changed accordingly."

　　It is easy to explain the transition from "1.0" to "2.0" with the model of mathematical function: if the tasks of image recognition, semantic understanding and chess playing are all regarded as different Y=f(X), that is, the input picture, voice or chess move of "cat" is "x", and the output cat, answer and chess move is "y". Before deep learning, people find the formula corresponding to function F through their own analysis and tell it to AI. After deep learning, people input a lot of correspondence between x and y, and AI finds the formula corresponding to function f by itself.

　　"The specific content of the function F found by AI may be better than that found by humans, but humans don’t know it, just like a black box." Mo Yu said, "But the form of F is designed by AI researchers through research. If deep neural network is used, the modules in the network and the organization between modules are also designed in advance."

　　With the maturity and popularization of deep learning technology, there has been a specific pursuable experience in model construction. "The release of various common neural networks has made the threshold for employment lower and lower. Some ordinary model construction and optimization, just graduated students can get started in online learning tutorials. " Zhao Zhigang said.

　　When modeling becomes a learnable skill, AutoML appears. What it can do is the model design work of AI researchers. "It will help different companies build artificial intelligence systems, even if they don’t have extensive expertise." Google engineers recommend this. AI successfully evolved to 3.0.

　　In fact, AutoML still replaces the work that human beings can extract experience. "If people described a set of &lsquo; Road network &rsquo; With the technical assistance of deep learning, the machine can find the optimal path as quickly as possible; Then AI can now design its own road network. " Zhao Zhigang was concise.

　　It can be seen that both deep learning and AutoML only replace the work that some groups of human beings have studied thoroughly. "What machines can do, try not to work by hand" is the life creed of many programmers, which gave birth to AutoML. Based on the same creed, Microsoft developed DeepCoder. "It can be used to generate programs that satisfy given input and output." Mo Yu said, but its performance is not satisfactory at present, and only some simple programs can be written.

　　Who is "God"

　　There is no doubt that the answer is human.

　　Since AI has evolved to a higher level of model design, what changes have taken place in the "hand of God"?

　　"An alchemist", Mo Yu vividly talked about his work in two words. "Smart is a professional intelligent customer service. The work of R&D personnel mainly focuses on problem modeling (how to turn actual problems into problems solved by artificial intelligence technology) and algorithm optimization (how to improve the effect of artificial intelligence algorithms)."

　　"refining" means constant debugging and improvement. "For a specific person, the more you throw your temper, the better. The more accurate the answer, the better." Mo Yu said, "Our X is the customer’s question, Y is the reply of the robot customer service, and the middle function F needs training."

　　This is not an easy task. If we divide the experience of human society into three categories: definite rules with formulas, knowledge that can be expressed in words, and feelings that can only be understood but cannot be expressed. The last category is the most difficult to ponder.

　　"Therefore, we try to build a perfect closed-loop feedback, understand the preferences of specific users, and finally achieve what they like through the expression of emotions and interests." Mo Yu said, "At present, it is in the stage of man-machine collaboration, but the acquisition of more and more samples will help our intelligent customer service to give accurate and pleasing answers."

　　It can be seen that not all fields are suitable for AI’s self-development. For example, in the aspect of problem modeling, how to abstract practical problems into machine learning problems can not be completed by AI. In the stage of AI2.0, R&D personnel also need to design the form of function F manually.

　　So, what will be the future of AutoML popularization?

　　"Humans are liberated from lower-level jobs." Zhao Zhigang said, "If the model design can be done by AI, then AI researchers will explore more the design of the basic modules that make up the model."

　　"Developing AI models with AutoML is similar to children playing with &lsquo; Lego &rsquo; Toys. " Zhao Zhigang put it in simple terms, and the designers of Lego disassembled the whole world into detailed modules, so that everything could be used and then combined into complex models. The higher level of human work is to find basic units, that is, modules, for AI in different fields. For example, in the field of image recognition, humans have designed various modules such as convolution and pooling. "AutoML can build a model based on this, and constantly adjust the module combination to obtain a more reasonable output. The finer the module, the more versatile it can be, and the more self-developed AI can be used. " Zhao Zhigang said.

　　Extended reading

　　 Where are the talents needed by the industry?

　　Alleviating the shortage of talents is the main selling point of AutoML. "AI systems are blooming everywhere, but AI talents are far behind." Google explains why AutoML is indispensable. What is the current status of AI talents?

　　In 2017, the Global AI Talent Report and the BAT Artificial Intelligence Talent Development Report were released one after another. "The shortage of AI talents is real." Xu Wenjuan, vice president of Shengshi Investment Group, said, "The shortage of talents in start-up and development enterprises is particularly serious. From the current global perspective, the United States has the largest number of AI talents, and China’s AI talents can’t be compared with it in terms of number of people and experience. "

　　Zhao Zhigang has the same feeling: "China’s AI field is short of veterans, experts, generalists and top masters." The optimization and debugging of the model requires experience, the exquisite design of the model requires superb skills, and the application of AI in various industries requires compound talents. In addition, there are only a handful of top talents leading the development direction of AI, and most of them are abroad.

　　Xu Wenjuan introduced that China has the most AI talents in BAT (Baidu, Ali, Tencent). Generally, there are several kinds of background experiences of such talents, such as returnees, BAT work experience, or from universities or research institutes.

　　"AI self-development should not be able to replace people’s work in the short term, and there is still a long way to go." Xu Wenjuan said. Zhao Zhigang analyzed from an academic point of view: "Only when human beings design AI models in different application fields and further decompose them into a series of general modules, such as the periodic table of elements in chemistry, DNA and RNA in biology, can this self-development have more applications."

　　According to the Southeast Network (Reporter Feng Chuanye correspondent Song Yaxin), the "May Day" holiday is coming, and many car owners have already made travel plans. The reporter learned from Fujian Expressway Energy Company that Fujian Expressway has laid out charging stations in more than 100 pairs of service areas and built more than 900 charging piles, of which the coverage rate of fast charging stations is as high as 88%, and the charging service network of expressway intercity traffic in the province has basically taken shape.

　　This year’s "May 1 ST" holiday arrangement is: April 29 to May 3, a total of 5 days. Free passage time is five days during the May Day holiday in 2023 (from 0: 00 on April 29th to 24: 00 on May 3rd), and Fujian Expressway will continue to implement the free passage policy for passenger vehicles with less than 7 seats (including 7 seats).

　　The high-speed department predicts that the public’s willingness to travel during the "May 1" Golden Week this year is very strong. Combined with the comprehensive analysis and judgment on the changes of expressway traffic in the whole province during the May Day holiday in recent years and the Qingming holiday this year, it is predicted that the overall expressway traffic in our province will rise sharply during the May Day holiday this year, which is expected to break through the level of the same period in previous years and hit a new record high. The travel groups are mainly long-distance inter-provincial tours and short-distance trips to go on road trip. It is suggested to plan the route scientifically and rationally stagger the peak trips.

　　In order to facilitate the travel of electric car owners, Fujian Expressway has sorted out the list of service areas where charging stations have not yet been laid out, helping car owners to plan their trips in advance, avoiding entering the service area without charging stations by mistake and improving charging efficiency.

　　The service area of the charging station has not yet been laid out as follows:

　　Fuzhou area: Longtian service area of Fuzhou-Xiamen Expressway and Wutong service area of Puyan Expressway;

　　Zhangzhou area: Huangtian service area of Pingmei Expressway, Banzi Yutang service area and Meifeng service area of Guping Expressway;

　　Longyan area: Rentian Service Area of Zhangwu Expressway, Ancient City Service Area of Xiamen-Chengdu Expressway and Tufang Service Area;

　　Sanming area: Fengxi service area, ancient ginkgo service area of Shaxia Expressway and Dajin Lake service area of Puwu Expressway;

　　Tips for using charging piles

　　1. During the charging process, the vehicle should be parked and turned off, and it is not allowed to move at will.

　　2. Check the charging pile, charging cable and charging gun for obvious appearance damage before charging the gun. If there is any damage, charging should be prohibited.

　　3. When charging, the charging gun should be inserted to the end, otherwise the equipment protection function will be prohibited from being electrified.

　　4. After starting charging, the charging equipment and lines are electrified at this time. Despite multiple protection measures, you should try to avoid touching the charging equipment again.

　　5. It is forbidden to plug and unplug the charging gun forcibly when the charging is not over, and it is forbidden to press the emergency stop button in non-emergency situations.

　　6. Non-professional operation and maintenance personnel are strictly forbidden to disassemble or modify the charging equipment.

　　Situation of high-speed power exchange stations in the province

　　In cooperation with Weilai Energy Company, Fujian Expressway Energy Company has operated five power stations in three pairs of service areas with large traffic and high power demand in the province, including one second-generation power station and four third-generation power stations.

　　Compared with the second-generation station, the third-generation power station has the advantages of higher efficiency, stronger service and smarter operation. It only takes 3-4 minutes to complete the power exchange, and the daily service times can reach 408 times, which can realize the functions of calling vehicles and automatically changing power, and can comprehensively improve the experience of power exchange owners.

　　Tips for using Weilai Power Station

　　1. Navigate to the nearest power exchange station by calling NOMI, and the locomotive system will prompt whether it is necessary to make an appointment for power exchange in advance, click OK, and then go directly to the power exchange station;

　　2. After arriving at the power exchange station, a power exchange prompt will pop up on the central control panel, and the owner can choose to park automatically and enter the power exchange station, or back up by himself and let the power exchange station staff back up and enter the power exchange station;

　　3. After the vehicle stops in the power exchange station, it will automatically start to change power. After the power exchange is completed, the vehicle will give a prompt, and then it can directly drive out of the power exchange station.

　　In the next step, Fujian Expressway will encrypt the network layout of power stations, and strive to achieve one power station every 100 kilometers of expressway. It is estimated that 11 power stations will be added to Fujian Expressway during the year, which will radiate the sections of Shenhai Expressway, Jingtai Expressway and Changshen Expressway in the province. This will greatly enhance the convenience service capacity and provide a strong "green power support" for high-speed electric vehicles to travel to Fujian Expressway.

　　Line up for spicy food.

　　Tempting Gansu mala Tang.

　　"Bouquets of vegetables" are one after another, and enthusiastic diners are one after another. After Tianshui Mala Tang went out of the circle, this "sky-splashing flow" also began to flock to Lanzhou, and the passenger flow of major Mala Tang shops in the city continued to rise obviously. Embracing this wave of traffic dividends, on March 20th, famous local restaurants in Lanzhou took advantage of the situation to offer a new "Gansu Mala Tang" and add another fire with innovative dishes. Even the University of Science and Technology Beijing, thousands of miles away, issued an official announcement, "The campus canteen window, authentic Tianshui Mala Tang in Gansu, is officially launched"!

　　A Lanzhou hot spicy dip famous store huo Shang Jia huo

　　When visiting Lanzhou, Jin Lan Mala Tang in Anning District must be on the must-eat list.

　　At noon on March 19, looking at the endless diners, Ms. Chen, a citizen of Lanzhou, lamented: "Jin Lan Mala Tang, which is deeply loved on weekdays, has become more popular recently!" This is an old-fashioned Mala Tang shop in Lanzhou. The proprietress’s name is Wen Jinlan, and she is from Longnan, Gansu Province. She has been here for more than 20 years. After the hot spicy dip in Tianshui, more and more diners came here, and sometimes they even had to wait in line for an hour to eat.

　　In order to meet the huge passenger flow, it is normal for Wen Jinlan to get up early for nearly 20 hours every day. The reason why it is popular, in the view of the proprietress Wen Jinlan, is because of "popular taste, everyone likes it". The raw materials such as Gangu pepper, Wudu Dahongpao pepper, vermicelli specially customized from Dingxi and grain vinegar produced nearby have jointly contributed to the mouth-watering "spicy and hot".

　　"A large pot of vegetables, all kinds of ingredients wrapped in red juice, a spoonful of crisp sour radish, and the smell of oily spicy seeds between chopsticks directly hit the taste buds." Every meal, Yanji Mala Tang in Zhengning Road, Chengguan District, all the tables inside and outside the store are full. Many people ask, after more than 30 years of opening, people are so popular that there must be an exclusive secret recipe, right? Mr. Zeng, the boss, said frankly: "My wife and I are out-and-out Jianyang people in Sichuan. We have lived in Lanzhou for decades. We improved and adjusted the proportion of juice according to the tastes of local people, which reduced the hemp degree of pepper. It brings together Gansu local materials such as Dingxi Kuanfen and Gangu Chili, forming a unique flavor of Gansu Mala Tang. "

　　B Lanzhou local catering enterprises innovate dishes.

　　On March 20th, Duanji Hotel in Yantan, Lanzhou officially launched the new dish "Gansu Mala Tang". Yang Guoyan, Chairman of the Folk Food Committee of Longcai Association and Deputy General Manager of Lanzhou Duanji Catering Management Co., Ltd., told Benben News reporter: "In order to meet this wave of traffic, we have developed a new dish close to Tianshui Mala Tang, with ingredients such as Gangu Chili, Dingxi Kuanfen and Qin ‘an Zanthoxylum. As a Longcai hotel, our goal is to create a &lsquo; Ganwei hot spicy dip &rsquo; The alternative ingredients will be more extensive, adding lily, yak meat and so on. " Yang Guoyan said that many employees in the store are from Tianshui. Through repeated trial production for many days, this new product has been officially launched.

　　"After Tianshui Mala Tang is on fire, how can we seize this wave of traffic and continue to undertake this heat to Lanzhou? In fact, we still have to work hard on product innovation." Yang Guoyan said, "Gansu is more delicious than mala Tang, Wuwei &lsquo; Three sets of cars &rsquo; , Zhang Ye &lsquo; Stir-fry firecrackers &rsquo; , Longnan stirred up the group &hellip; &hellip; Longshang cuisine has a long history. How to make use of this mala Tang craze to make all kinds of snacks in Gansu known to more people and promote them to the whole country requires not only the help of the cultural tourism department, but also the joint efforts of the catering industry and other departments. "

　　C "Gansu Mala Tang" online orders skyrocketed.

　　According to the data of Meituan, since March, the search volume of keywords related to "Gansu Mala Tang" has increased by 18.5 times from last month, and the number of public comments has soared by 13.2 times. The take-away orders of Gansu Mala Tang increased 66 times from last month. Beijing, Xi ‘an, Jinan, Shanghai and Tianjin are the top five cities in search volume.

　　At the same time, the popularity of Tianshui Mala Tang has also driven the growth of local cultural tourism consumption. The booking volume of travel orders in Tianshui City, Gansu Province increased by 71.8% compared with the same period of last year. Among them, the order volume of hotels and homestays increased by 73.6% year-on-year, and the order volume related to scenic spots increased by 216.8% year-on-year. Maijishan Grottoes, Fuxi Temple, Maijishan Hot Springs, Xianrenya and Yuquan Temple are the top five scenic spots in terms of order volume. Shaanxi, Henan, Jiangsu, Guangdong, Ningxia, Beijing and Sichuan are the top provinces and cities in the source of off-site orders.

　　On various social platforms, many netizens called for authentic Gansu Mala Tang to be eaten in their hometown, and called on Tianshui people to open stores in their hometown. Some physical stores that see business opportunities are trying to seize the opportunity &hellip; &hellip;

　　Gansu Beijing Office, located in Beijing Feitian Mansion, has recently put up "Gansu Mala Tang", attracting many netizens to taste the punch card. And a female shopkeeper from Tianshui also decided to open a Gansu Mala Tang restaurant in Sanlitun, one of the hottest business districts in Beijing, which is expected to be officially opened in half a month.

　　On March 19th, University of Science and Technology Beijing issued a document saying that "Gansu Tianshui Mala Tang" will be launched in the school cafeteria at noon. In order to reflect the authenticity, the school emphasized that "soul juice" is all from Gansu, and it brings together two ingredients of Tianshui, namely Gangu pepper and Qin ‘an pepper. The potato powder is elastic and smooth, Gangu chili pepper is full of oil, and the most delicious thing is the intersection of fresh hemp and Qin ‘an pepper. In fact, as early as 2012, the school established a fixed-point assistance relationship with Qin ‘an County, Gansu Province, and purchased Qin ‘an pepper every year. This year, a new potato powder procurement project was added, and the canteen master went to the local area for research and study, bringing students a better experience.

　　Searching with "Gansu Mala Tang" as the key word through Tianyanchao platform, in the past three months, there have been more than 200 new Mala Tang shops in China. Among them, since February this year, there have been more than 150 newly opened Gansu Mala Tang shops in China. According to the data of Tianyancha Professional Edition, up to now, there are more than 9,600 mala Tang related enterprises in Gansu, while there are nearly 900 related enterprises in Tianshui City alone.

　　Text/Figure Benliu News Lanzhou Morning News reporter Xu Jingwen

　　Cctv newsOn December 25th, snow or sleet occurred in central and southern Shaanxi, southwestern Shanxi, Henan, western Shandong, western Hubei and other places, with the cumulative precipitation of 1-5 mm and local area of 6-10 mm in central Shaanxi.

　　Affected by cold air, this morning, the temperature dropped by 6 ~ 8℃ in eastern and southern Qinghai, eastern Gansu, Ningxia, Shaanxi, northwestern Shanxi, central Inner Mongolia, southeastern Heilongjiang and central and eastern Jilin, with a local drop of 10 ~ 12℃. It is estimated that in the next three days, the temperature will drop by 4~6℃ in the eastern part of Northwest China, the central and eastern Inner Mongolia, the western part of North China and the eastern part of Southwest China, and the local temperature drop can reach more than 8℃. There are 4~5 winds and gusts of 6~8 in some areas mentioned above.

　　It is expected that there will be a rainy and snowy weather process in the southern region from the night of today to the 29th. There will be small to medium snow or sleet in eastern Tibet, northern Yunnan, western Sichuan Plateau, southeastern Chongqing, Guizhou, western Hunan, western Hubei, southern Anhui, northwestern Zhejiang and other places, heavy snow in central and eastern Guizhou and western Hunan, and freezing rain in western Guizhou. There are light rains in Sichuan Basin, south-central Yunnan, southern Hunan, most of Jiangxi, most of Zhejiang, northern Fujian, Guangxi and northern Guangdong, and local rains; The main precipitation period is from 27th to 28th.

　　In addition, there will be light snow in eastern Inner Mongolia, Heilongjiang and northern Jilin tomorrow and tomorrow.

　　Meteorologists reminded that there are still strong winds and cool weather in the northern region affected by cold air activities, and the public needs to take protective and warm measures; There will be rain and snow in many places in the south, and public travel needs to guard against the adverse effects of slippery roads and reduced visibility.

BA.4 and BA.5, the new branches of Omicron with stronger communication power, have recently attracted attention. The new branch has triggered a new infection peak in South Africa, and the Portuguese National Institute of Health also estimates that its growth advantage is 13% more than that of BA.2.

Screenshots from the nextstrain website show that the different Omicron branches represented by yellow, orange and red are iterating rapidly within half a year, and the new branches represented by orange and red are also expanding in the cracks.

Screenshot of nextstrain website. According to the uploaded sequencing data, since December last year, the mainstream branches in Omicron have gradually changed from BA.1 (shown as 21K) to BA.2 (shown as 21L) to BA2.12.1 (shown as 22C), and the area occupied by new branches is also expanding.

The new branches of Omicron are frequent. Is the current COVID-19 vaccine still effective? Do the branches BA.2 and BA.5 need their own vaccines? Should the update of COVID-19 vaccine keep up with the variation of virus? How to keep up with the virus mutation? With the above questions, the reporter of Science and Technology Daily contacted and interviewed a number of industry experts.

Is the current vaccine still effective?

Does the mutation branch in Omicron constantly trigger new infection peaks, which means that the current COVID-19 vaccine will be invalid?

Authoritative experts in the industry responded to the Science and Technology Daily reporter and said: "Current vaccines can still provide the most basic protection in ensuring the reduction of severe illness and death.. The epidemic in COVID-19 has been going on for two and a half years. At present, it seems that there is no possibility for Covid-19 to achieve zero infection through vaccination. COVID-19 vaccine can ensure the effect of reducing infection and avoiding serious illness and death. "

Regarding the role of the current vaccine in epidemic prevention and control, the person in charge of vaccine-related production enterprises in COVID-19 holds the same view: "The existing vaccine is no problem in preventing severe illness and death at present, but it will not be 100% anti-infection."

Many statistics or research results from the real world show that the current vaccine plays a significant role in preventing severe illness and death. For example, the latest data in Hong Kong (as of May 25th) showed that the mortality rate of those infected in Omicron who were not vaccinated was 3.04%, while the mortality rate of those infected with three doses of vaccine dropped significantly to 0.04%.

Do the branches BA.2 and BA.5 all need their own vaccines?

According to WHO’s latest weekly report on epidemiological progress in COVID-19 (May 25th),Omicron BA.2 and its progeny pedigree (BA.2.X) have become the main popular variants in the world.At present, the relative proportions of BA.2.X, BA.4 and BA.5 are 94%, 0.8% and 1% respectively.

This shows that during the evolution of Omicron mutant, the branch BA.1 is disappearing. However, the reporter learned that at present, most vaccines against Omicron in China are designed and developed for BA.1.

Whether it is necessary to develop new vaccines for new branches, the industry generally judges from the perspective of vaccine protection: if the activity of neutralizing antibodies produced by the original vaccines against mutant strains is greatly reduced, it is necessary to develop new vaccines; If it still has a good neutralizing effect on the mutant, there is no need to develop a new vaccine.

Although Omicron strain mutates rapidly and different branches appear, butNew vaccines will not be introduced for each branch, and there is no need to do so.. Relevant experts reminded: "If you continue to monitor, you will find that many mutations will disappear soon."

Can vaccine update keep up with virus iteration?

In the technical route of vaccine development in COVID-19, the design cycle of mRNA vaccine is short. On the basis of a mature platform, the design can be completed within 7 days, and the preclinical trials including animal experiments can be completed in about one month.

Industry experts engaged in the research and development of mRNA vaccine said that for the variant branch, the mRNA vaccine does not need to obtain the strain, but only needs to optimize the vaccine sequence according to the variant sequence and test the expression efficiency, and then pre-clinical trials can be carried out. Covid-19 Omicron mutant mRNA vaccine, developed by Suzhou Aibo Bio, China, has been approved for clinical research in UAE.

In response to virus variation, the technical route of inactivated vaccine can also complete the preclinical study of new strains in a short time by establishing an emergency system. The reporter previously learned that it can be advanced to the clinical trial application stage about 2 months after obtaining the new strain.

Keep up with the variation, can COVID-19’s vaccine market learn from the "flu model"

In order to cope with the frequent mutation of viruses, there are precedents for vaccine updates to follow closely. For example, the influenza virus vaccine is recommended by WHO every year, and countries produce new influenza vaccines accordingly.

In order to keep up with the variation in Covid-19, can the "flu model" be used for reference in the marketing of vaccines in COVID-19?

“It is estimated that the future development of COVID-19 vaccine needs to adopt the influenza model.The authoritative experts mentioned above responded, but WHO is unable to recommend mainstream strains through monitoring now, because the pandemic is not over yet.

Another advantage of the "flu model" is that it greatly shortens the time to market for new vaccines. Because there is no need for re-approval, its batch issuance system can effectively shorten the period from vaccine development to marketing. Experts in the industry said that after polishing and construction, various technical routes and platforms have gradually matured, the research and development speed has been accelerated, and the production process has been stable.If the "flu model" can be adopted in the development and marketing of vaccines in COVID-19, the time to market for new vaccines will be greatly shortened.

WHO has revealed some unexpected phenomena in its weekly epidemiological report: available data show that BA.4, BA.5 and BA.2.12.1 spread faster in countries where BA.1 was once prevalent, but less in countries where BA.2 was prevalent; The vaccination degree of each country may have an impact on the popularity of the new branch of Omicron. Visible,Covid-19 mutation and vaccine immunogenicity are mutually causal and widely related, and updating the vaccine in time may have an impact on virus mutation.

Source: Science and Technology Daily

Original title: "Omicron iterates fast, is it necessary to be" anxious "about the vaccine? 》

Read the original text