State and municipal people’s governments, provincial committees, offices, departments and bureaus:

"Twenty-eight measures to further optimize the business environment and better serve the market players in Yunnan Province" have been agreed by the provincial people’s government and are hereby printed and distributed to you, please implement them carefully.

General Office of Yunnan Provincial People’s Government

November 6, 2020

(This piece is publicly released)

Yunnan Province further optimizes the business environment and provides better services.28 measures of market main body

In order to implement the spirit of the "Implementation Opinions of General Office of the State Council on Further Optimizing the Business Environment and Serving Market Subjects Better" (Guo Ban Fa [2020] No.24), we will further focus on the concerns of market subjects, especially the pain points faced by enterprises under the normalization of epidemic prevention and control, accelerate the creation of a market-oriented and legalized international business environment of "doing business in Dont Ask For Help, not meeting for approval, running at most once" and "ensuring full service", and promote Yunnan’s high-quality leap-forward development.

First, further enhance the convenience of investment and construction.

(1) Focus on optimizing the pre-approval process of investment projects. We will comprehensively promote the reform of "one thing at a time" in the early stage of the project, strengthen the coordination of departments, strengthen the connection between project approval and construction conditions such as land use and planning, and promote qualified States and cities to realize the "one thing at a time, one thing at a time" in the early stage of investment projects. Accelerate the interconnection and data sharing between the online examination and approval supervision platform of investment projects in Yunnan Province and relevant examination and approval systems, and realize online printing of documents such as one-time declaration by project units, one-time handling by examination and approval personnel and approval. Accelerate the implementation of regional evaluation reform measures, and organize regional evaluation in China (Yunnan) Pilot Free Trade Zone and various development zones, industrial parks, new districts and other regions with conditions, so as to speed up the project landing.(led by the Provincial Development and Reform Commission and the Provincial Department of Housing and Urban-Rural Development; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(two) efforts to improve the efficiency of examination and approval of construction projects. Accelerate the classified management of engineering construction projects, clarify the types of engineering construction projects according to industries, formulate corresponding management measures, and uniformly issue differentiated licensing conditions. On the premise of ensuring safety, for small-scale low-risk new construction, renovation and expansion projects of construction projects and social investment with a project investment of less than 1 million yuan or a construction area of less than 1,000 square meters, enterprises will make relevant commitments after obtaining land and meeting the conditions for commencement, and the government departments will directly issue relevant certificates, and the projects can start. We will further promote the implementation of reform tasks such as parallel approval, joint drawing review and joint acceptance of completion, speed up the improvement of the examination and approval management system for engineering construction projects in Yunnan Province, and promote the docking with platforms such as public resource trading, planned land use and credit China (Yunnan), so as to share and interconnect data in real time. Before the end of 2020, the examination and approval items involved in each stage of the examination and approval process of engineering construction projects will be included in the online platform, and the standards and fees will be handled publicly, so as to realize the whole process of examination and approval of engineering construction projects at the provincial, prefecture and county levels. In 2020, the approval time of government investment projects will be reduced to less than 90 working days, in 2021 to less than 70 working days, and in 2022 to less than 50 working days.(led by the Provincial Department of Housing and Urban-Rural Development and the Provincial Department of Natural Resources; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(3) Efforts should be made to promote the integration of multiple regulations. Promote the construction of a "one map" of the province’s land spatial planning, and accelerate the integration of main functional area planning, land use planning and urban and rural planning into a unified land spatial planning system based on the results of the third national land survey. Accelerate the "multi-survey integration", pay close attention to the preparation of technical regulations for joint surveying and mapping of construction projects in Yunnan Province, and gradually establish and improve the mechanism for coordination of surveying and mapping business and data update and sharing required for "multi-survey integration" to realize "one-time entrustment, joint surveying and mapping and achievement sharing" in all stages of construction projects.(led by the Provincial Department of Natural Resources; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

Two, to further simplify the approval and conditions of production and operation of enterprises.

(4) Resolutely clean up hidden barriers to market access. Strictly implement the national unified market access negative list system, and all kinds of market entities can enter the fields other than the market access negative list equally according to law. Introduce a third-party evaluation mechanism to regularly evaluate and evaluate the implementation of policies and measures related to market access, comprehensively investigate and systematically clean up all kinds of explicit and implicit barriers, and continue to promote the universal implementation of "non-forbidden access".(Provincial Development and Reform Commission takes the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(5) Continue to expand the supply of medical services. Optimize the layout of medical resources, encourage social capital to run medical services, and implement filing management for clinics in nursing homes, clinics in China (Yunnan) Pilot Free Trade Zone and Chinese medicine clinics that only provide Chinese medicine services, further strengthen supervision and improve the quality of medical services in clinics.(Responsible by the Provincial Health and Wellness Committee)

(six) improve the management of industrial products production license. Conscientiously do a good job in undertaking and implementing the management authority of production licenses for important industrial products such as construction steel bars and cement delegated by the state. Dynamically adjust the production license management catalogue of industrial products in Yunnan Province. Optimize and improve provincial certification procedures, documents and relevant regulations before the end of 2020.(Provincial Market Supervision Bureau takes the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(seven) to optimize the management measures of motor vehicle production and circulation. Vigorously promote the sharing and application of motor vehicle production, sales, registration, maintenance, insurance, scrapping and other information, promote online handling of motor vehicle transactions, strengthen supervision after the event, and enhance the transparency of motor vehicle circulation. Strictly implement the policy of completely canceling the restrictions on the removal of used cars, give priority to setting up registration service stations in qualified used car trading markets and used car distribution enterprises, and further simplify the registration procedures for used car distribution enterprises to purchase motor vehicles. Strictly implement the national tax reduction and exemption policies for optimizing new energy vehicles, and actively promote the healthy development of new energy vehicle industry in our province.(Provincial Department of Commerce, Provincial Market Supervision Bureau, Provincial Public Security Department and Provincial Taxation Bureau take the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(8) Accelerate the reform of "one photo with multiple addresses". In Kunming, Qujing, Yuxi and Chuxiong, we will promote the pilot reform of "one photo and multiple addresses", simplify the registration procedures for enterprises to set up branches, and facilitate the registration of market entities.(Provincial Market Supervision Bureau takes the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(9) Further reduce the production and operation costs of small and micro enterprises. It is strictly forbidden for platform enterprises to abuse their dominant market position and charge unfairly high service fees. On the premise of ensuring workers’ occupational health, appropriately reduce the detection frequency of occupational hazard factors in small and micro enterprises with general occupational hazards, and effectively reduce the production and operation costs of enterprises. (Provincial Market Supervision Bureau and Provincial Health and Wellness Committee take the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(10) standardize the deposit fees for enterprises. Strictly implement the list system of enterprise-related margin announced by the state and our province, and complete the return of cancelled margin funds, overdue or overcharged margin funds before the end of 2020. In the fields of engineering construction, government procurement, etc., we will steadily implement insurance, letters of guarantee, etc. instead of cash to pay enterprise-related deposits, further reducing the financial pressure on enterprises.(Provincial Department of Industry and Information Technology, Provincial Department of Finance, Provincial Department of Housing and Urban-Rural Development, and Provincial Development and Reform Commission take the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

Third, further optimize the business environment of foreign trade and foreign-funded enterprises

(eleven) improve the efficiency of import and export customs clearance. Strictly implement the national reform and deployment, vigorously promote the "declare in advance" customs clearance mode for import and export goods, establish a contact and cooperation mechanism between the territory of the customs area and the port customs, and go through the declaration procedures in advance for qualified goods, and the customs will go through the inspection and release procedures immediately after the goods arrive at the workplace under customs supervision. Vigorously promote the customs clearance mode of "two-step declaration" for imported goods, and allow enterprises to take the goods out of the port supervision place after the enterprises make a "summary declaration" and the customs completes the risk investigation and disposal. Vigorously carry out the pilot project of customs clearance of imported goods on arrival, and use smart card ports to improve the efficiency of customs clearance. Vigorously carry out the whole process monitoring and marking of inspection operations, and allow enterprises to choose whether to accompany the inspection independently in areas where conditions permit, thus effectively reducing the burden on enterprises. Vigorously promote the integrated customs clearance linkage supervision mechanism, strengthen law enforcement cooperation with Chongqing, Chengdu, Nanning and other customs to ensure the stability of the production supply chain of enterprises. It is strictly forbidden for ports to simply take unreasonable measures such as one-day flow restriction and customs declaration control to shorten customs clearance time.(Kunming Customs takes the lead; Provincial departments, the relevant state and municipal people’s governments shall be responsible for the division of responsibilities)

(12) Expand the "single window" function of international trade. Improve the application rate of "single window" in an all-round way, and achieve 100% application rate of major declaration business by the end of 2020. Do a good job in the publicity and promotion of the "single window" of international trade, guide enterprises to apply for supervision certificates involved in import and export links through the "single window", and the relevant departments will handle and implement supervision separately in the background.(Provincial Department of Commerce and Kunming Customs take the lead; Provincial departments, the relevant state and municipal people’s governments shall be responsible for the division of responsibilities)

(thirteen) to support foreign trade enterprises to invest and operate. Before the end of 2020, the implementation plan of Yunnan Province to support the export of goods to domestic sales will be introduced, the export of goods to domestic sales will be intensified, and the supervision during and after the event will be strengthened. Actively strive for Zhaotong City, Wenshan Prefecture, Diqing Prefecture and Nujiang Prefecture, which have not been authorized, to obtain the authorization of the General Administration of Market Supervision for the registration and management of foreign-invested enterprises, so as to achieve full coverage of the registration and management of foreign-invested enterprises in cities at prefecture level and above in the province.(led by the Provincial Department of Commerce and the Provincial Market Supervision Bureau; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

Fourth, further reduce the threshold for employment and entrepreneurship

(fourteen) optimize the employment conditions of some industries. Promote the cancellation of the qualification examination for road cargo transport drivers except road dangerous goods transport, and incorporate the relevant examination training contents into the corresponding level of motor vehicle driver’s license training. Drivers can apply for the qualification certificate for road cargo transport drivers with the training completion certificate and motor vehicle driver’s license. Do a good job in the registration examination of practicing veterinary qualifications, the filing of practicing veterinary qualifications and the filing of rural veterinarians. Before the end of 2020, formulate relevant measures to accelerate the mutual recognition of workers’ physical examination results in Yunnan Province, and further reduce the burden on job seekers. By the end of June 2021, the online verification of professional and technical personnel’s professional title information will be realized across regions, and mutual recognition of professional titles between States and cities will be encouraged.(Provincial Department of Human Resources and Social Security, Provincial Department of Transportation and Provincial Department of Agriculture and Rural Affairs take the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(fifteen) actively carry out "shared employment" and flexible employment. Accelerate the construction of Yunnan professional and technical personnel management service information platform, actively do a good job in the work of migrant workers in real-name registration system, classify and match according to enterprise industry, employment position and employee specialty, guide enterprises in need in the province to carry out "shared employment", and strive to solve the employment problem. Fully implement the responsibility of territorial management, adhere to the combination of management and supervision, scientifically and reasonably set the business premises and opening hours of mobile vendors, and promote the active employment of flexible employees under the conditions of ensuring safety and health and not harming public interests.(led by the Provincial Department of Human Resources and Social Security, the Provincial Department of Housing and Urban-Rural Development and the Provincial Market Supervision Bureau; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(sixteen) optimize the unemployment insurance procedures. According to the national policies and regulations, unify the procedures for unemployment insurance transfer in the province, simplify the procedures for applying for unemployment insurance, strictly implement the policy of issuing unemployment insurance transfer in the province according to the standards of the place of immigration, and promote the rational allocation and orderly flow of human resources.(led by the Provincial Department of Human Resources and Social Security; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(17) Optimize the inclusive and prudent supervision measures for new formats. Encourage innovations in new technologies, new industries, new formats and new models, and study and formulate a list of impunity for minor violations of laws and regulations by citizens, legal persons and other organizations in major administrative law enforcement fields. Establish a "fault-tolerant" mechanism, warn and reason the first minor illegal act that is not subjective and intentional and has no harmful consequences, and guide citizens, legal persons and other organizations to consciously correct it, generally without administrative punishment.(led by the Provincial Development and Reform Commission, the Provincial Market Supervision Bureau, the Provincial Department of Justice and the Provincial Department of Science and Technology; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(eighteen) vigorously develop Internet diagnosis and treatment services. Under the premise of ensuring medical safety and quality, qualified medical institutions are encouraged to carry out Internet diagnosis and treatment services and telemedicine services, and hospitals that meet the standards are encouraged to apply for setting up Internet hospitals. Incorporate qualified Internet medical services into the scope of medical insurance reimbursement in our province. Accelerate the review and approval of innovative medical devices and drugs and promote clinical application.(Provincial Health and Wellness Commission, Provincial Medical Insurance Bureau and Provincial Market Supervision Bureau take the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(nineteen) to strengthen the promotion of new business application scenarios. Accelerate the deployment of new infrastructure such as 5G networks, data centers, blockchain technology cloud platforms, artificial intelligence, industrial Internet, and Internet of Things, and expand application scenarios in agriculture, industry, transportation, urban governance, public services, and government services. We will continue to explore the deep application of "one mobile phone" in government services, social governance, public services, smart tourism, cross-border trade and finance, and optimize the brand of "one mobile phone". Accelerate the "one cloud" construction of Yunnan government affairs and promote the open sharing of government affairs data.(Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

V. Further improve the service quality and efficiency of enterprises.

(twenty) to promote the convenience of enterprises to start operations. We will fully implement the "one-window service platform" for enterprises, set up a comprehensive service window for "enterprises", and realize online and offline "one-form application and one-window payment" for enterprise registration, official seal engraving, invoice application and tax control equipment, employee insurance registration and housing provident fund account opening registration. In 2020, the start-up time of enterprises in the province will be reduced to less than 3 working days, in 2021 it will be reduced to less than 2 working days, and in 2022 it will reach the national advanced level. Relax the restrictions on the registered business premises of small and micro enterprises and individual industrial and commercial households, fully implement the "enterprise residence commitment system" and "enterprise name independent declaration", and improve the efficiency of enterprise name declaration and registration. Vigorously promote the use of electronic business licenses, electronic invoices and electronic seals, and accelerate the realization of "one license for quasi-operation and cross-regional mutual recognition". By the end of 2020, we will complete the cleanup of all kinds of compulsory newspaper announcements, and actively do a good job in canceling or adjusting them to online free announcements.(Provincial Market Supervision Bureau, Provincial Public Security Department, Provincial Taxation Bureau, Provincial Department of Housing and Urban-Rural Development and Provincial Department of Human Resources and Social Security take the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(twenty-one) to speed up the promotion of government services "one thing at a time" and "cross-provincial". Deepen the reform of "doing one thing at a time", strengthen the connection with relevant state ministries and commissions and provinces (autonomous regions and municipalities), and realize "inter-provincial operation" of 58 items such as market subject registration, pension insurance relationship transfer and connection, professional qualification certificate verification, education notarization and driver’s license notarization by the end of 2020, and realize 70 industrial product production licenses, medical treatment settlement filing, social security card application and household registration transfer by the end of 2021. Accelerate the iterative upgrade of "one mobile phone service" and continuously improve service functions.(The general office of the provincial government takes the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(twenty-two) to continuously improve the level of tax service. Improve the function of electronic tax bureau, carry out "non-contact" tax payment service in depth, and implement the whole process of online taxation. Expand the application of "one mobile phone to handle taxes and fees" and promote the use of blockchain technology electronic bills. In accordance with the unified arrangements of the State Administration of Taxation, simplify the declaration procedures of preferential tax policies such as value-added tax, and launch a pilot project of electronic special invoices for value-added tax before the end of 2020, so as to realize 90% online processing of major tax-related services and 80% sharing of basic tax information. Strengthen the data sharing of taxation, customs, people’s bank and other departments, and speed up the progress of export tax rebate. In 2020, the normal business control of export tax rebate (exemption) in the whole province will be completed within 7 working days, and the normal business control of export tax rebate (exemption) in China (Yunnan) Pilot Free Trade Zone will be completed within 6.5 working days.(Provincial Taxation Bureau takes the lead; Kunming Customs, Kunming Central Sub-branch of the People’s Bank of China, relevant departments at the provincial level, and people’s governments at the state and municipal levels shall be responsible for the division of responsibilities)

(twenty-three) optimize the chattel secured financing services. Promote the unified registration of chattel security, integrate all kinds of chattel registration and rights guarantee registration systems, and encourage and guide commercial banks to support small and medium-sized enterprises to carry out secured financing with movable property and rights such as accounts receivable, production equipment, products, vehicles, ships and intellectual property rights. Promote the construction of financing platforms such as "a mobile phone cloud enterprise loan" to further solve the financing difficulties and expensive problems of private enterprises and small and medium-sized enterprises.(Kunming Central Branch of the People’s Bank of China, Provincial Department of Finance, Provincial Department of Agriculture and Rural Affairs, and Yunnan Banking Insurance Regulatory Bureau take the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

6. Further improve the long-term mechanism for optimizing the business environment.

(twenty-four) to establish and improve the policy evaluation system. In accordance with the statutory authority and procedures, draft or formulate local laws, government regulations and administrative normative documents closely related to the production and business activities of market entities, and make full use of newspapers, online government service platforms, "two micro-terminals" and "one mobile phone to handle affairs" to solicit opinions from the public. The period for soliciting opinions is generally not less than 30 days, and relevant procedures such as fair competition review and legality review shall be performed in strict accordance with regulations. Conscientiously implement the "red and black list" system of business environment, the "good and bad review" system of government services, optimize the response system of complaints and reports on business environment, carry out evaluation work on a regular basis, continuously optimize various index systems, and give full play to the guiding role of business environment evaluation.(The general office of the provincial government, the Provincial Development and Reform Commission and the Provincial Department of Justice take the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(twenty-five) to strengthen the normalization of relations between government and enterprises. Give full play to the role of enterprises and trade associations as a bridge between enterprises, and establish a normalized and standardized communication mechanism between government and enterprises. We will conscientiously implement the system of linking leading cadres with private enterprises, establish and improve the mechanism for entrepreneurs to participate in the formulation of enterprise-related policies, and fully listen to the opinions of market entities and industry associations and chambers of commerce on enterprise-related policies.(The general office of the provincial government and the Provincial Department of Industry and Information Technology take the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(twenty-six) to carry out credit classification supervision. Strengthen the construction of credit information sharing platform and industry credit information platform in Yunnan Province, and comprehensively collect public credit information according to the unified public credit information catalogue of the whole province. We will comprehensively promote the application of prior commitments and credit reports. Actively carry out public credit evaluation and industry credit evaluation, and strengthen the application of classification results. Improve the joint punishment mechanism afterwards and strengthen the protection of the rights and interests of market participants. Accelerate the "internet plus Supervision and Supervision", promote the mutual support and integration of supervision and supervision, and promote smart supervision and supervision.(led by the Provincial Development and Reform Commission and the Provincial Market Supervision Bureau; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(twenty-seven) to accelerate the integration of government service hotline. Strengthen the construction of "Yunnan 12345 government hotline", accept the demands of enterprises and the masses in a unified way, conscientiously do a good job of transfer and supervision, respond to the demands of enterprises and the masses in a timely manner, and continuously improve the satisfaction of enterprises and the masses.(The general office of the provincial government takes the lead; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

(twenty-eight) pay special attention to the implementation of the policy of benefiting enterprises. Accelerate the establishment of a unified policy declaration system for enterprises in the province, with unified entry, one-click declaration and backstage distribution, and gradually realize the service of "one release, one acceptance and one consultation" for enterprises’ policies. The policies of provincial departments to benefit enterprises are pushed to the platforms of "Yunnan Government Service Network" and "One Mobile Phone Service" within one week of promulgation or update, and the policies of state, city, county and district to benefit enterprises are pushed to the government portal within one week of promulgation or update. When the county government introduces the policies to benefit enterprises, it is necessary to announce the relevant responsible persons and contact information. Actively promote the policy of benefiting enterprises "free of application and enjoy".(led by the Provincial Department of Industry and Information Technology; Provincial departments, state and municipal people’s governments are responsible for the division of responsibilities)

All localities and relevant departments should earnestly implement the above measures and study and introduce more practical and effective reform measures around the needs of market players. Cancellation and decentralization of administrative examination and approval items cannot be "released at once", and supervision after the event should be strengthened. Special industries and key areas directly related to public safety and people’s life and health should be supervised and the bottom line of safety and quality should be kept. The relevant implementation shall be submitted to the general office of the provincial government before 10 December 2020.

Many pharmaceutical companies were fined for producing and selling inferior drugs! Recently, Shanghai Food and Drug Administration issued an administrative penalty decision. The contents of the announcement show that the "Dissolution" of omeprazole enteric-coated capsules (specification: 20mg, batch number: 201211) produced and sold by Shanghai You Mei Pharmaceutical Co., Ltd. did not meet the requirements after supervision and inspection. It is reported that in December 2020, the parties produced 23,970 boxes of omeprazole enteric-coated capsules, and all of them were sold out. From September 29 to December 24, 2021, the parties took the initiative to recall the products, recalling a total of 6085 boxes. The parties actually sold 17,885 boxes of this batch of drugs. The value of this batch of drugs is RMB 83,895, and the illegal income of the parties is RMB 55,396.02. [Result] According to Article 117 of the Drug Administration Law, Shanghai Food and Drug Administration imposed the following administrative penalties on Shanghai You Mei Pharmaceutical Co., Ltd.: confiscation of 6085 illegal omeprazole enteric-coated capsules (specification: 20mg, batch number: 201211); Confiscation of illegal income of RMB 55,396.02; A fine of one million five hundred thousand yuan only (1,500,000 yuan). It is understood that omeprazole enteric-coated capsules, as a commonly used medicine for the treatment of stomach diseases, occupy a high market share in digestive diseases. According to the data in the Minenet, the overall market size of omeprazole enteric-coated capsules in China domestic market is about 2.278 billion yuan in 2020. However, the omeprazole enteric-coated capsules produced by Shanghai You Mei Pharmaceutical Co., Ltd. were found to be unqualified and punished, which may have a certain impact on the company. Therefore, it is hoped that the enterprise will strengthen the supervision of drug production.If you commit another crime next time, the punishment may be more severe.　

A pharmaceutical company was fined again for producing inferior drugs. In addition, in recent days, Fujian Food and Drug Administration has also issued an administrative punishment information disclosure form, which has publicly punished two pharmaceutical companies. It was found that the companies punished this time were Fujian Qiancao Pharmaceutical Co., Ltd. and Fujian Yangzu Pharmaceutical Co., Ltd. Among them, Fujian Yangzu Pharmaceutical Co., Ltd. was ordered by the Food and Drug Administration to immediately correct and give a warning for failing to implement the drug traceability system in accordance with the regulations. Fujian Qiancao Pharmaceutical Co., Ltd., however, was given a warning by the Food and Drug Administration, confiscated illegal income and fined 100,000 yuan, with a total penalty of 101,700 yuan, because the traditional Chinese medicine decoction piece Gentiana macrophylla produced and sold was found to be unqualified. It is worth noting that this pharmaceutical company has been punished four times by the Food and Drug Administration in the past two years.

On December 1, 2021, an administrative penalty information form issued by Fujian Province showed that the Chinese medicine decoction piece wine dogwood meat (batch number is 200501, specifications are unified, and packaging specifications are 1kg/bag) produced by the pharmaceutical company failed to meet the requirements after inspection. On September 8, 2020, the parties concerned sold all the above wine dogwood meat and got a sum of 2,760 yuan. Therefore, the Drug Administration Law of the Food and Drug Administration stipulates that the company was fined a total of 1,002,760 yuan. 　

On June 18, 2021, Fujian Food and Drug Administration issued a notice saying that the Cortex Dictamni Radicis, Radix Peucedani and roasted Herba Epimedii produced by Fujian Qiancao Pharmaceutical Co., Ltd. did not meet the requirements, and they were fined a total of 33,610.8 yuan. 　

In November 2020, Fujian Food and Drug Administration issued an announcement that the acanthopanax bark produced by this enterprise did not meet the project requirements, and it was fined 2,457 yuan according to law. 　

In October, 2020, Fujian Food and Drug Administration issued a penalty message. Because the produced Chinese herbal pieces of Cortex Lycii and Rhizoma Menispermi did not meet the requirements of the project, they were fined 2.5 times the value of 8604 yuan, totaling 21510 yuan.

In just over a year, the company fined more than one million yuan for producing inferior drugs, involving as many as eight unqualified varieties. Under such a high unqualified rate, the Food and Drug Administration will inevitably strengthen supervision over the company. It is worth mentioning that during November 2020, Fujian Food and Drug Administration issued a notice saying that Fujian Qiancao Pharmaceutical Co., Ltd. applied to cancel the Pharmaceutical Production License and Pharmaceutical GMP Certificate of the parties according to law, and then the company stopped production.　

Multi-provincial Food and Drug Administration publicizes illegal activities of pharmaceutical companies Coincidentally, the local medical health station also noticed that at least six pharmaceutical companies have been punished by publicity in the past month, involving enterprises in Guangxi, Inner Mongolia, Hubei Province and other places. Among them, Baotou Yiren Pharmaceutical Co., Ltd., Bozhou Jinshaotang Chinese Herbal Pieces Co., Ltd. and Anhui Wei Wu Chinese Herbal Pieces Technology Co., Ltd. were punished by the Food and Drug Administration for producing and selling inferior drugs; Guangxi Jirentang Pharmaceutical Co., Ltd. and Shanghai Pharmaceutical Holdings Zhenjiang Co., Ltd. were punished for selling inferior drugs; Hubei Huquan Pharmaceutical Co., Ltd. was punished by Hubei Province for not strictly implementing the relevant requirements of good manufacturing practice. See the following table for details of specific penalties: 　

Under the strict supervision of the national pharmaceutical department, both pharmaceutical trading enterprises and production enterprises will be punished once they violate the provisions of the Drug Administration Law. Therefore, for enterprises, compliance and legal production and operation is the king of survival.　

Source: Medical Health Local Station　

Typesetting: Joyce　

Editor: Adam

Original title: Lotus House: the genre exploration, spiritual core and cultural imagination of the costume martial arts drama.

In the summer file of domestic dramas in 2023, costume dramas such as Changfeng Du, Sauvignon Blanc, Lotus House, Lucky at Seven o’clock and Lord Snow Eagle occupied half of the hot list. Under the background of network integration, IP development, content is king, element superposition and in-depth marketing, costume dramas maintain a high-profile trend, promote the drama series to go out to sea, and trigger a heated discussion and audience climax. Looking at the domestic costume drama in the summer of 2023, on the basis of insisting on the costume as the creative background, it fully integrates many elements such as Xian Xia, fantasy, mystery, suspense, detective story, comedy, Machiavellian, love, etc., and realizes the characteristic breakthrough of "harmony but difference" and shows the innovative practice of vertical categories under the costume drama track. Among them, the costume suspense detective drama "Lotus House" stands out in the highly competitive drama series with excellent story content and excellent production methods. Douban scored 8.1, and the theme broadcast volume totaled 10 billion, which was rated as an S+ TV series and became one of the fine martial arts dramas with both word-of-mouth and popularity.

The martial arts drama Lotus House is adapted from Teng Ping’s novel Lotus House in Ji Xiangwen. It is directed by and co-directed, starring and Aero. The drama tells the story of Li Xiangyi, the master of Sigumen, who was famous in the Wulin, who fell into a cloud of doubt after the East China Sea War ten years ago, and became a magical doctor of Jianghu, Li Lianhua, and then got involved in a river-lake dispute again, showing a thrilling and complicated chivalrous story.

Integrating "Martial Arts+Detective Cases" and Realizing the Exploration of "Type+"Creation

As an important branch of costume drama, costume detective drama has made quite dazzling achievements, bearing the common memory of a generation. From the series of Bao Qingtian in the 1990s to the series of Hong Kong dramas "Remembering Injustice" in the Millennium, and then to the series of Detective Di Renjie, Young Bao Qingtian, Arrested Officials in the Great Song Dynasty, Four Famous Arrests and Strange Man and a Plum in the early 21st century, detective dramas in ancient costume have gained a good reputation and become one of the favorite TV series. After 2010, costume detective drama entered the creative bottleneck, and the overall performance was not good, and gradually faded out of the TV screen. In recent years, with the great achievements and popularity of costume detective dramas such as Young Tales of the Great Song Dynasty, I don’t know about the Chivalrous Detective Jane, The Longest Day In Chang’an’s Under the Golden Clothes, The Imperial Courtesy, Daming under the Microscope, The League of Gentlemen, and The Mysteries of the Tang Dynasty, this theme has returned to the audience’s sight. This summer, the reputation of Lotus House exploded, which made the audience see the creative potential and type innovation of costume detective drama again.

Looking at the suspense detective dramas of ancient costume in recent years, the four outstanding sub-types are mystery, love, women and juvenile home country. In these sub-types, comedy, youth, ancient style, martial arts, highway and other elements are gathered, which conforms to the current trend of "genre+"and realizes the variation of the detective drama of ancient costume, which is very attractive and ornamental. The popularity of "Lotus House" is that after the integration of "martial arts+detective cases", comedy, suspense, tactics and other elements are superimposed, and the word-of-mouth counterattack is realized with the setting of "unit mystery+unconventional protagonist setting+treacherous light and dark in Jianghu temples", which has gained high popularity and discussion.

As for Lotus House, which focuses on martial arts and suspense, with the battle between good and evil caused by Sigumen and Jinyuan Alliance as the story background, 10 mysterious cases, such as the case of the golden body rising, the case of the female house, the case of yipin grave and the case of picking lotus village, are connected in series in the interweaving of two clues: "Looking for the remains of a single solitary knife" and "Nanyin’s plot to restore the country". In the bizarre case, there is a chivalrous atmosphere, which promotes the audience to experience the story in an immersive way in the rhythm of relaxation. Of course, judging from the theme presentation and genre exploration of Lotus House, the first half of the plot is full of suspense, and the "Detective Lotus League" composed of Li Lianhua, Fang Duobing and the sound of flute flying has formed a deep friendship in laughing and cursing, and jointly promoted the development of the plot; In the second half of the plot, the heroic spirit and chivalrous spirit of the rivers and lakes are more obvious, and a period of stirring chivalry is launched on the basis of clarifying the main line of the story. Although the drama strives to pay equal attention to martial arts and suspense elements, there are obviously too many intrigues and confusing cases in the whole work, and there are fewer young heroes and chivalrous righteousness in the martial arts drama. This also shows that although the creation of "genre+"drama series is a trend, it is more necessary to properly handle the superposition and genre mixing between elements.

Chivalry and ordinary people, rich spiritual core and cultural artistic conception

As netizens commented, "Lotus House" "tells an indifferent but not thin chivalrous feeling and ideal of home and country with a different kind of Jianghu story." The most valuable thing is that "Lotus House" shows the good and evil of human nature from the perspective of "love and affection" on the basis of martial arts dramas, and expresses the strong practical significance behind the truth of each case. From Li Xiangyi, the master of Sigumen, who is famous in Jianghu, to Li Lianhua, a leisurely Jianghu doctor, behind the change of identity is still a generation of heroes who stick to the bottom line, stick to themselves, have a just mind and are devoted to life.

For Lotus House, it is precious to examine rivers and lakes, humanity and home country from a male perspective, especially the respect for women and the concern for women’s emotional world, which makes people particularly moved. In the "Women’s House" unit, the women who were abducted into the deep house by Yu Louchun were like prisoners, losing their right to choose and be free. These women are both murderers and victims. They unite and watch each other in the women’s house, resist malice with their weak bodies, and strive to save themselves in desperation. At the end of the case of "The Woman’s House", the audience was deeply grateful for their good ending. In the "Palace Blissful Tower" unit, in the face of the rebellion of Shan Gudao and others, Li Lianhua and Fang Duobing broke the cocoon in layers of difficulties, uncovering the secret of royal blood relationship that can shake the world. In order to better stabilize the rivers and lakes and temples, Li Lianhua used the only flower that can last for a long time to detoxify Emperor Daxi, and saved everyone with his own body. The chivalry presented in Lianhu Building is more about the responsibility and the sense of home and country with "serving the country and the people and caring for the world" as the spiritual core.

In addition, Lotus House presents the pursuit of artistic conception aesthetics through a large number of traditional cultural symbols. This unity of reality and reality, which is born outside the image, has a unique expression in Lotus House. Because Li Lianhua misses Master, she dances a sword in the bamboo forest, and the bamboo leaves flying with firm but gentle waves present her own Zen beauty, which conforms to Li Lianhua’s uninhibited and worldly state of mind, and also reproduces the literary landscape of "a sword floating, a towel and cloth" in poetry. At the end of the drama, Li Lianhua broke his sword and flew off a cliff and jumped into the river. At this time, the river was misty and rainy, and the clouds surged with it. Coupled with the rendering of the background music of A Pot of Lotus Drunk, Li Lianhua’s broad-minded state of mind was integrated with the surrounding environment, just like the true portrayal of "The boat died from now on, and Jiang Hai sent the rest of his life" in Su Shi’s Linjiangxian. At this time, when the camera turned, Li Lianhua put pen to paper, showing the emotional changes and aesthetic artistic conception that the open-mindedness of time has passed, the hope of protecting the people and the original heart, and realizing the world, all beings and their own life realm among all sentient beings.

Although the summer file of domestic dramas has come to an end in 2023, the costume detective craze brought by Lotus House continues, and the number of costume detective dramas to be broadcast alone has surpassed 10 such as The Case of the Tang Dynasty Digong, The Apocalypse, Under the Fancheng and The Westbound Journey of the Tang Dynasty. On the basis of "costume+detective stories", these dramas fully integrate fantasy, suspense, comedy, thriller, adventure and other elements, create distinctive types, and attract the audience’s attention with complicated unsolved stories. However, only blindly pursuing the superposition of elements and genre innovation can easily lead the detective drama of ancient costume into the wrong path of creation. On the basis of local culture, we should dig deep into the plot, strengthen the characters, clarify the logical relationship, and explore more diverse genre creation and value propositions.(Author: Yue Zongsheng, a postdoctoral fellow at Tsinghua University School of Journalism and Communication, this article is a major national social science project "Audio-visual quality products promote the creative transformation and innovative development of Chinese excellent traditional culture", with the project number of 22ZDA083)

　　CCTV News:Beginning in the second half of 2013, in the party’s mass line education practice activities, the Supreme Leader General Secretary explicitly requested that we should focus on the construction of work style and focus on solving the "four winds" problem.

　　"waste on the tip of the tongue", "extravagance on wheels" and "corruption in festivals" … … The extravagant enjoyment that these people hate has been effectively curbed, and the inertia of unhealthy trends has been reversed, but formalism and bureaucracy still exist to some extent. A series of anti-four winds reports broadcast by CCTV on December 13th is typical.

　　The report said: "There is such a slogan of civilized convention along the street in Shenmu County, Shaanxi Province, which was signed by Shenmu County Propaganda Department and Civilization Office, but the first sentence was ‘ Love your country, love your family and love me Changsha ’ . This not only directly copied other people’s content, but also did not check it. 48 words are not bad. "

　　Not only "Shenmu loves Changsha", but also "Zhengzhou loves Baoji". A publicity column for creating a civilized city in Zhengzhou reads "Humanistic Baoji, Vigorous Baoji and Harmonious Baoji". I was commented by netizens that "it’s really embarrassing!"

　　Imagine that this kind of city propaganda work, which is related to the appearance of the city, will not make such low-level mistakes and become a laughing stock as long as it is a little more serious and careless. Undoubtedly, this kind of careless work will not achieve any good results. In addition, there is a kind of work that is done only for the sake of form, which not only has no effect, but also makes the people disgusted and makes the grassroots uncomfortable. For example, some "show" research activities now.

　　In a municipal district in Jiangxi province, during the 22 working days in July this year, 12 city-level cadres went to the district for investigation, and only 7 were received on the 27th. In some places, it is like creating a tourist route to create a classic research route. No matter what the research topic is, leading cadres follow the same line, interview the same group of people and listen to the same set of rhetoric. As a result, some units and the masses have become professional households under investigation, and a set of rhetoric has been told to different leaders countless times.

　　This kind of "catwalk" research not only interferes with the normal work order at the grassroots level, but also increases their burden, which obviously runs counter to the central government’s request that "grassroots research should not go through the motions".

　　In addition, formalism and bureaucracy have many varied manifestations. Some local meetings are held one after another, and there is no time to implement them; Some leading cadres say one thing and do another, both on stage and off stage; Some cadres are ignorant of existing problems and let them go; There are still some places where "the soldiers and horses have not moved, and the experience has been gained". At the beginning of the work, they are eager to sum up their achievements, publicize typical examples, and use materials to make a set of achievements … …

　　No matter what form these formalism and bureaucracy take, it will do great harm to the construction of our party and country, and also seriously damage the image of the party and government in the hearts of the people. The reason for this kind of behavior of going through the motions is that these cadres in party member do not pay attention to the feelings of the people, and fail to achieve the "four haves" mentioned by the General Secretary: having the party in mind, having the people in mind, having responsibilities in mind, and having a warning in mind.

　　If you have a party in your heart, you will consciously maintain a high degree of consistency with the Party Central Committee and consciously safeguard the authority of the Party Central Committee. No matter where you work or in which position, you must stand the test of storms, strengthen your ideals and beliefs, be loyal to the Party, and never go astray or go astray in the political direction.

　　If you have people in your heart, you will be selfless and self-denying, and you will always have people in your heart. Think deeply and look down on one’s reputation, status and interests. We will make great efforts to solve the most direct and realistic interests of the people, especially to solve the problems that the people are dissatisfied with.

　　If you have a responsibility in your heart, you will have a responsibility. You won’t just think about being an official and not wanting to be an officer. You just want to take power and don’t want to take responsibility. You just want to be brilliant and don’t want to contribute. To be an official, we must really solve some problems for the local authorities, and we will grasp the final work deployment and finish it well.

　　If you have a warning in your heart, you will correctly exercise your power, use your power according to law, justly and incorruptibly, so that you can be fearful, keep your words and stop your actions, and handle the relationship between public and private, affection and law, interest and law. And always be strict with yourself, consciously carry forward and practice the socialist core values, strengthen moral cultivation, eliminate distractions and do things cleanly, and leave a good reputation in the hearts of the people.

　　Since the 18th National Congress of the Communist Party of China, the Central Commission for Discipline Inspection has resolutely implemented the spirit of the Eighth Provisions of the Central Committee, persistently corrected the "four winds", severely punished those who violate discipline against the wind and never tolerated them.

　　Ji Jianye (data map)

　　In 2014, Ji Jianye, the former mayor of Nanjing, was suspected of serious violation of discipline and law. Its leading rain and sewage diversion project with an investment of 18 billion yuan has become the target of public criticism. A project with such a huge cost has never held a public hearing, nor has it listened to the opinions of experts and scholars. It was launched only by "one word". This matter has been criticized by the local people so far.

　　In 2016, Wang Zhigang, the first secretary of the former Party branch and the poverty alleviation team leader of Fengguang Village, Shuihou Town, Qianshan County, Anqing City, Anhui Province, lost the information of a certain household, which caused the household to be unable to enjoy the industrial poverty alleviation support in that year. In order to cope with the inspection and fraud, it was removed from the post of the first secretary of the village party branch and the poverty alleviation team leader.

　　Since January 2017, the Water Affairs Bureau of Ding ‘an County, Hainan Province, the Huancheng Committee and Han Yue and others have had problems in cracking down on illegal sand mining, such as lax law enforcement, ineffective crackdown, and inadequate work, which has led to repeated prohibitions on illegal river sand mining. In September 2017, seven units, including County Water Affairs Bureau, Huancheng Committee, Transportation Bureau, Dingcheng Team of Traffic Management Brigade of Public Security Bureau, Dingcheng Police Station, Xiangou Police Station and Longzhou Police Station, were seized by informed criticism, and many related persons were held accountable.

　　… …

　　From the investigation and punishment of "four winds" by the discipline inspection and supervision organs this year, from January to October 2017, 37,800 cases of mental problems violating the eight central regulations were investigated and punished nationwide, among which more than 9,600 cases of disciplinary violations occurred in 2017, accounting for 25.5% of the total investigation and punishment in that year, which shows that the phenomenon of not converging and not stopping still exists, and the violations against the wind are still increasing.

　　The problem of "four winds" has a long history, its causes are complicated, and it is influenced by historical culture, traditional concepts, social customs and other factors. It cannot be completely solved overnight, nor can it be solved once and for all. Recently, the General Secretary of the Supreme Leader made important instructions on checking and correcting formalism and bureaucracy, emphasizing "correcting ‘ Four winds ’ Can’t stop, work style construction is always on the road ",once again releasing a strong signal to the whole party — — Unswervingly and comprehensively manage the party strictly, and constantly improve the style of work. (Text/Li Shanshan)

　　[Tracing the dispute over the hometown of celebrities]

　　Why Zhuji sent an urgent letter to Xiaoshan?

　　On February 15th and 16th, Shi Zhiban and Zhuji Municipal People’s Government of Zhejiang Province sent official letters to Zhejiang Local Records Office and Xiaoshan District Government, respectively, asking them to maintain the historical truth, and to cancel or change all the contents of Xiaoshan City Records’ false "hometown of Xi Shi".

　　What makes Zhuji people even more angry is that at the beginning of the new year in 2017, the relevant departments of Xiaoshan vigorously launched a slogan on Line 2 of Hangzhou Metro, the provincial capital: Millennium ancient town, hometown of Xi Shi, vibrant Linpu! Zhuji thinks this is a real false advertisement.

　　"On the evening of August 21st, 1959, when Chairman Mao Zedong passed Zhuji and met Sun Zifu, then secretary of Zhuji County Party Committee, on the special train, he said: Zhuji is a famous place, and beauty Xi Shi and painter Wang Mian are both here …" Comrades from the Propaganda Department of Zhuji Municipal Committee told reporters that they could not accept the "dispute over Xi Shi’s hometown" that began 30 years ago.

　　The reporter learned that in 2015, Xiaoshan City Records violated the Regulations on the Work of Local Records, and listed Xi Shi, an ancient man 2,500 years ago, as the number one biography of modern Xiaoshan City Records for the first time, and shouted for the first time that Xiaoshan was a place where Gou Jian was working hard. In 2016, Xiaoshan created a large-scale live-action musical "Xi Shi" and invited Tan Dun to invest 258 million yuan to sing "Xiaoshan is the hometown of Xi Shi".

　　This series of actions of Xiaoshan has made this debate heated up.

　　In 1986, Xiaoshan discovered that Mao Qiling, a scholar from Xiaoshan in the early Qing Dynasty, once quoted Liu Zhao’s annotation and wrote: "Yue Jue" said: Xiaoshan is the place where Xi Shi came from. " Wang Wei, a teacher in Xiaoshan, often published the article "Xi Shi came out of Xiaoshan", saying that "Xi Shi came out of Xiaoshan, which was first seen in the Book of the Later Han Dynasty". It is also believed that "Xi Shi was born in Zhuluo village in Yuedi (now Zhuluo village in Linpu, Xiaoshan)". "War" thus kicked off.

　　"According to historical records, the name of Xiaoshan County, which began in the Tianbao period of the Tang Dynasty, could not have appeared in Yue Jue Shu of the Han Dynasty. The Book of the Later Han Dynasty was written in Liu and Song Dynasties, more than 300 years earlier than the county name of Xiaoshan. According to Yuejueshu, there is no such text. It is not surprising that there are monuments of Xi Shi in Xiaoshan, because Xi Shi and Zheng Dan entered Wu from Vietnam, passing through Shaoxing, Xiaoshan, Deqing, Tongxiang, Jiashan, Huzhou, Suzhou and other places, and monuments commemorating Xi Shi appeared everywhere along the way, which some scholars call the’ Road of Xi Shi’. The’ historic site’ and’ hometown’ are completely different in nature, and the concepts cannot be exchanged to equate them. " Qi Caoliang, deputy director of Shi Zhiban, Zhuji City, told reporters that Zhuji and Shaoxing are the places where Gou Jian tried his best, and Huanjiang is in Zhuji. There has never been a Zhuluo village in Xiaoshan’s history. The present "Zhuluo Village" in Xiaoshan was formed by merging three natural villages in 2005. "Linpu has never belonged to Zhuji in history. Xiaoshan County was renamed from Yongxing in the first year of Tang Tianbao (742), and Linpu was called Linpuli as late as the Song Dynasty. "

　　Textual research on ten representative historical books at the national level and Shaoxing prefecture level before the Southern Song Dynasty, such as the Spring and Autumn Annals of Wuyue in the Eastern Han Dynasty (Xu Tianqiu’s annotation), the Records of Huiji in the Southern and Northern Dynasties, the Records of Ten Roads in the Tang Dynasty, the Notes of Taiping Yu in the Northern Song Dynasty, the Records of Jiatai Huiji in the Southern Song Dynasty and Fangyu.

　　Records of Zhuji County, which were officially edited by Zhuji officials, all have biographies and historical records of Xi Shi and Zheng Dan. There are only three Records of Xi Shi of Zhu Xi, which were officially edited by Zhuji officials in Ming and Qing Dynasties, and also include poems written by Xi Shi and Zheng Dan led by Zhu Yuanzhang, the founding emperor of Ming Dynasty. The inheritance is orderly, and there are endless books.

　　Zhuji pointed out that Xi Shi was never mentioned as a native of Xiaoshan in the Records of Xiaoshan County compiled by Jiajing, Wanli, Kangxi and Qianlong in the Ming and Qing Dynasties, and Xi Shi was not included in the biographies of county chronicles. Today’s "Xiaoshan City Records" has written Xi Shi, an ancient man more than 2,500 years ago, into a biography for the first time, which has neither inheritance nor historical basis.

　　This may be an argument that should not have happened.

　　This may be an argument that should not have happened.

　　Su Buqing, president of Fudan University, said: "The issue of Xi Shi’s birthplace has been recorded in history and verified by experts, which has long been conclusive. If you practice fraud, even if you get away with it for a while, it will be untenable in the future. "

　　In 2006, the State Council announced the first batch of national intangible cultural heritage lists, of which the tenth item was "Legend of Xi Shi" belonging to Zhuji City; In 2007, China Xishi Culture Research Center, a national regional cultural research center, was permanently located in Zhuji by the Ministry of Culture, which is a reaffirmation that Zhuji is the hometown of Xishi.

　　Successive Zhuji Municipal Party Committee and Municipal Government have done a lot of work in protecting the historical relics and cultural imprint of Xi Shi, and building Xi Shi Dian, Xi Shi Gallery, Xi Shi’s hometown scenic spot and beautiful countryside Xi Shi landscape belt. The local organization commemorates Xi Shi’s Lotus Festival every year, and holds Xi Shi Cultural Festival every two years, inviting friends, rural sages and experts at home and abroad to offer public sacrifices to Xi Shi.

　　He Jianmin, director of the Tourism Management Department of Shanghai University of Finance and Economics, said with emotion: "The dispute over the hometown of celebrities is actually a struggle for an iconic, attractive and revealing cultural tourism resource, so as to enhance the visibility of the region in the whole country or the whole city. With influence, there will be customers, which can attract investment and bring income. "

　　On the morning of 23rd, the reporter sent a message to contact Wang Zhihua, the section chief of Xiaoshan Shi Zhiban, and planned to conduct an interview on several issues: Xiaoshan said that Xi Shi’s hometown was in Xiaoshan. What is the conclusive historical basis? In the past, there was no saying in Xiaoshan local chronicles that Xi Shi’s hometown was in Xiaoshan. Why did it come up later in the new local chronicles? What is the idea that Xiaoshan started the dispute over Xi Shi’s hometown?

　　After not getting a reply, at noon, the reporter called Shi Zhiban directly in Xiaoshan, hoping to introduce and state some relevant information about the questions raised by Zhuji. However, the comrades who answered the phone declined the interview on the grounds that it was an "academic debate".

　　The reporter did not give up the interview: "At present, the two places hold their own words, but the materials provided by Zhuji are more detailed, so I hope Xiaoshan can also provide some statements. Your refusal to interview is actually a statement. "

　　Five minutes later, the reporter received a phone call from Wang Zhihua and promised to provide a "Xiaoshan statement" to the reporter. He sent the reporter an email entitled "The history of Xi Shi’s hometown has not yet been settled".

　　How should the 30-year-old debate end?

　　According to the "Xiaoshan theory":

　　In the Southern Dynasties, Liang Liu Zhao placed a bet on the "Yu Ji" in the History of the Later Han Dynasty: "Yue Jue" said: the place where Xi Shi came from. "

　　In the Northern Song Dynasty, Ouyang Yi wrote a book titled "A Wide Record of the Land" (Volume 22) and "On the Road between Zhejiang and Xiaoshan", saying: "Xiaoshan County is Benyu County, and the Han Dynasty belongs to Huiji County. At the end of the Han Dynasty, a nursery rhyme said: The son of heaven should flourish between the three southeastern regions, so Sun Quan changed his name to Yongxing County, and Jin was promoted because of it. Sui Province entered Huiji County. Tang Yifeng was reinstated in two years, belonging to Yuezhou. The first year of Tianbao was renamed Xiaoshan County. ….. The Vietnamese beauty is from this county. "

　　Zhuji believes that Xiaoshan’s statement needs to be refuted. They asked the reporter to forward the two posts of "Twenty Evidence of Xiaoshan’s Fake Hometown of Xi Shi" and "Xiaoshan’s Fake Hometown of Xi Shi Dare not Touch Six High Voltage Lines" to Xiaoshan, and asked them to carefully see if they could reply to the defense. Zhuji pointed out that the book Yue Jue Shu is a pure fraud, and it is false to check the original book. Xi Shi’s hometown is an immovable geographical coordinate. No matter how the construction evolution changes, the nature of historical sites and hometown is completely different.

　　On the evening of 23rd, the reporter sent the above two posts to Xiaoshan by email, asking them to express their views, but as of 5pm on 24th, the reporter had not received any reply.

　　"All publicity related to Xi Shi’s hometown and related contents, especially official history books, should be based on the records of previous dynasties, and should be based on national authoritative history books such as Cihai, Encyclopedia of China and Atlas of Chinese History. Xi Shi’s culture can be shared, but Xi Shi’s hometown cannot be invaded. " Qi Caoliang told reporters.

　　A scholar who has been paying attention to this matter and witnessed the whole debate feels sad: "We should spend more energy on the excavation and arrangement of Xi Shi culture, instead of turning over the history to compete for the hometown of celebrities for no reason."

　　The phenomenon revealed and reflected behind the dispute over Xi Shi’s hometown involves a series of issues, such as how to inherit China’s excellent culture, how to respect history and culture, and how to be honest in academic research. Experts suggest that the relevant departments in Zhejiang Province take the lead in organizing a seminar on Xi Shi’s hometown to solve this difficult cultural and academic problem and let all parties provide historical evidence on the spot. (Reporter Yan Hongfeng)

When it comes to Microsoft, Windows is definitely the first thing that comes to mind. As a top technology company that has been established for 46 years, Microsoft is actually doing what many software companies are doing every day — — Develop software.

So besides Windows, what other "giant hard artifacts" have Microsoft developed? The next article will give you a general overview.

Besides Windows, what other "giant hard artifacts" have Microsoft introduced?

1. Bing Wallpaper

Download: https://dl.pconline.com.cn/download/2746274.html

The dynamic wallpaper of MacOS is very enviable, but unfortunately … … Windows does not support it. However, a gadget called "Bing Wallpaper" can help us realize this dream.

The function of the software has been clearly displayed on the name. After installation, Bing’s daily wallpaper will be automatically downloaded and used as desktop wallpaper.

Bing Wallpaper can automatically update wallpaper every day.

Because the function is really simple, the software has not designed any function options. The only regret is that it doesn’t support 4K.

2. PowerToys

Download: https://docs.microsoft.com/zh-cn/windows/powertoys/

PowerToys is an official system enhancer produced by Microsoft, including color picker, screen splitter, keyboard mapper, batch image adjustment, batch renaming, quick search bar and other functional modules.

The idea of the software is not complicated, but it makes up for several aspects that have not been paid attention to in the current version of Win10. Among them, the quick search bar is the most concerned, not only because its appearance is similar to Spotlight of MacOS, but also because it can really improve the search usability of Windows to some extent.

In addition, if you are a "fish screen" user, its "FancyZones" can help you build a more flexible window arrangement layout.

And this will also improve the working efficiency of users on high-resolution displays to the greatest extent.

PowerToys system function enhancer

PowerToys’ imitation Spotlight search bar

3. Microsoft Whiteboard

Download: https://www.microsoft.com/store/productId/9MSPC6MP8FM4

If you have a Win10 tablet or like to paint on the computer, then this Whiteboard should be your dish. As its name suggests, Whiteboard is actually a "whiteboard" in a computer.

Users can write, draw, mark and take notes at will in the "whiteboard" with the help of a mouse, stylus, etc. In addition to being creative, you can also use Win10′ s teleconferencing mechanism to communicate and discuss with colleagues and customers in the "whiteboard".

Because the content of Whiteboard is stored in the cloud in real time, users can have a good operating experience whether watching or discussing.

Whiteboard

4. Sway

Website: https://sway.office.com/

Sway is a slide production website produced by Microsoft, but it doesn’t design many complicated functions and buttons like Powerpoint. Sway builds a presentation through story lines, which is very similar to the "outline" in Powerpoint.

Because it is an online application, the results generated by Sway can be played directly on the network, which makes it easier to share and spread.

However, Sway still supports the insertion of Bing search, OneDrive, local files and other resources, and its connection with Office is still very close. At the same time, slides can also be directly exported to Word, PDF and other formats, which is convenient for users to edit again.

Sway online slide production tool

5. To-Do

Download: https://www.microsoft.com/store/productId/9NBLGGH5R558

Microsoft To-Do is a tool launched by Microsoft, which supports Windows, Mac and Android. Different from Outlook professional task planning, To-Do is positioned as a lightweight task management tool.

You can set up different lists for homework, chores, travel and work, and manage your daily life in different categories.

In addition to multi-terminal synchronization and reminder, Microsoft To-Do also has daily list (My Day), task sharing and other functions, and you can log in directly with Microsoft account.

Lightweight task management tool To-Do

6. Office Lens

Download: https://dl.pconline.com.cn/download/369443.html

Generating paper files into electronic files is what we often call OCR. Office Lens is an OCR tool produced by Microsoft, which can quickly convert a paper document into an editable document.

The use of the software is very simple. First, take a photo of the document to be processed, and then select the saving mode as "OCR document", thus generating an electronic file.

Because OCR usually can’t achieve 100% recognition, Office Lens will paste the original image under each recognition result to facilitate user proofreading. In addition, the edge recognition of Office Lens is also very powerful, and the general file skew can be corrected automatically.

The recognition effect of Office Lens is good.

7. Microsoft AI knows the map

Download: WeChat applet

In addition to Office Lens, Microsoft also has a more powerful intelligent mapping tool, which is — — "Microsoft AI knows the map." However, unlike the APP form of Office Lens, "Microsoft AI Reading Map" is a WeChat applet.

Although they are all OCR recognition, "Microsoft AI recognizes pictures" is obviously more functional. In addition to the traditional character recognition, Microsoft AI has also added the functions of "changing words and saving pictures" (that is, modifying some words in the recognition results and saving them back in the picture), table restoration, English translation, PDF/PPT splicing and so on.

The most interesting thing is "Portrait Creation", which is similar to the dynamic template in Tik Tok or Photo APP. You can use your avatar to quickly generate personal profile, award-winning pictures, holiday wishes and other pictures. It sounds a little skinnier, right, but the playability is still good!

Character recognition

english translation

Portrait creation

Write it at the end

In addition to the above, Microsoft has actually produced other gadgets. Although not every one is a boutique, with strong technical strength, most of them are still good in functional performance. In short, Windows is not the whole of Microsoft, and Microsoft is by no means the endorsement of Windows. If you are interested, please give it a try.

Special feature of 1905 film network It has been 2309 days since the film "Lonely Lost" was released. In the last two or three days, it has been mentioned again. And what caused all this is a very emotional good news — — The DNA comparison of Guo Gangtang’s son, the prototype of Lost Orphan, succeeded!

Speaking of the touch when I just saw this news, Miao Yao, the host of this issue, said with emotion: "There are two exclamation points in my heart. The first exclamation point was actually found, and the second exclamation point was finally found."

The word "finally" expresses our faint hope that Guo Gangtang will find his son because of his persistence. In 24 years, he traveled all over 31 provinces, autonomous regions and municipalities in China and broke 10 motorcycles. Guo Gangtang’s persistence finally got the best answer.

In 2010, it was precisely because of Guo Gangtang’s insistence that director Peng Sanyuan saw the news of his search for children and paid attention to the abducted groups, and made the film "Lonely".

Wang Jian, a guest commentator of Today’s Film Review, said: "It is precisely because of the social reality reflected in this film that our whole society pays more attention to this phenomenon that we have changed the corresponding legal text and upgraded the corresponding crimes of abducting and selling children and women, including the public security organs launching a" reunion "action and taking more powerful measures to save these broken families."

The social reality reflected in "Lonely Lost" and the influence of Andy Lau, the leading actor, made more people pay attention to this social problem. When talking about the original intention of filming, film director Peng Sanyuan was also very emotional.

"The original intention of filming at that time was to hope that the whole society would pay special attention to such groups. They knew that such a thing would happen around us, and they should know that the evil chain of traffickers always existed."

"On the one hand, I wanted to help the abducted children go home and help the parents who are looking for children to reunite with their loved ones as soon as possible."

"There is also the hope that we can remind the public that we should protect our children and avoid being separated from them because of negligence or even because of gang robbery by criminals. Therefore, it is not too much to protect our children. If we can do this, I feel that our film has not been shot in vain."

The director’s two wishes have now come true, and the film has not only been shot in vain, but also updated its own best ending. Many viewers are particularly concerned about whether "Lonely Lost" will be shown in the cinema in today’s situation, and many netizens especially hope that Peng Dao can shoot the story after the reunion.

Director Peng Sanyuan also responded to the earnest invitation of the audience and netizens: "In fact, I have seen many netizens’ appeals. It is possible for us to shoot Lonely 2, but we should not bother Guo Zhen and Guo Gangtang. On the contrary, I feel that this father and son should no longer enter the public eye from now on, and let them quietly spend time repairing their family ties that have been cut off for 24 years. "

"Because of the renewed affection, it takes time. Only time can cure everything. Maybe they need two years, maybe three years, five years or ten years. So I think that up to now, we will not use another film to disturb their peaceful life, but I will pay attention. " Continue to pay attention not only to the running-in of affection between Guo Gangtang and Guo Zhen’s father and son, but also to other groups that are still separated from their relatives.

In this issue, guest Wang Jian also mentioned another film, Dying to Survive, which reflects social reality. "As Director Peng said just now, she made such a film because she paid attention to reality, and will not give up her continued concern for reality because she finished the film. Many of our films are actually affecting reality. For example, Dying to Survive directly promoted our corresponding anticancer drugs into our medical insurance catalogue, such as the revision of our Drug Administration Law. "

Wang Jian mentioned: "Art works must first reflect real life. At the same time, if you can change the reality through your own strength in the process of artistic creation and let the society develop in a better direction, this is in itself a very important responsibility for our film practitioners. "

Indeed, as a filmmaker, it is very precious to reflect the social reality we see to the public in artistic creation.

"The development and progress of our society has come to this day. In fact, the whole social group has become more and more detailed. Whether each minority group has received social attention and care, and his problems and demands have been solved, from this point of view, it also spurs and encourages more artists to pay attention to every corner of our society and pay attention to everyone’s inner demands. "

The Lost Orphan is undoubtedly a very successful film, which makes us pay attention to the group of lost and abducted children. At the same time, we also hope and believe that more and more movies will reflect and influence reality and make society better.

　　Changchun, China, March 11 (Reporter Guo Dongyu) How important is a good seed for food production?

　　"Good seeds, good rain and good moisture can make us look forward to a bumper harvest year." Han Fengxiang of Fenghuangshan Agricultural Machinery Farmers’ Professional Cooperative in Lishu County, Siping City, Jilin Province said.

　　"The contribution rate of excellent varieties to grain production has reached more than 45%, which plays a vital role in national food security." Zhang Zhijun, a researcher at the Corn Research Institute of Jilin Academy of Agricultural Sciences, said.

　　"I have a dream, buried in the soil, convinced that it is different. Light gives it hope, rain nourishes it and grows with the seeds. " Yuan Longping, the father of hybrid rice, said.

　　A small seed, one tied to the people’s rice bowl and the other tied to the national strategy (photo by Yang Guangwang)

　　This year, the No.1 Document of the Central Committee proposed that the seed industry should be revitalized in depth, the pace of industrialization of corn and soybean biological breeding should be accelerated, the pilot scope should be expanded in an orderly manner, and planting management should be standardized.

　　Recently, the reporter walked into Gongzhuling City, the founding unit of the National Modern Seed Industry Park and a national-level rice seed production county, to see how Jilin people on the black land grasped the "core" of grain.

　　Organic fertilizer "waits" for the next field (photo by Yang Guangwang)

　　In the more than 20,000 mu seed field of Hongxiang Seed Industry Co., Ltd. (hereinafter referred to as "Hongxiang Seed Industry") in Gongzhuling City, the land has been turned over and the organic fertilizer has been piled up at the edge of the field. "This seed production base was transferred last year. We used the method of black land protection to produce seeds. After a year of practice, the seed quality is very good." He Wei, general manager of Hongxiang Seed Industry, said.

　　Walking into the seed cultivation room, a fresh new green brings ying ying spring. "This is our trial variety and we are testing the emergence rate." He Wei said, "The seedlings in this germination box grew the day before yesterday, and each leaf of them contains a lot of information, which is very important for us breeders." Here, enterprises invest about 50 million yuan in maize breeding every year. "We carefully selected the seeds and planted them in the experimental field. Through the growth and yield, we found those plants with less diseases, lodging resistance and high yield."

　　A piece of new green "nurtures" the hope of a bumper harvest (photo by Yang Guangwang)

　　In addition to constantly researching and developing new varieties, how to make seeds more suitable for modern agricultural production methods is a problem that the Corn Research Institute of Jilin Academy of Agricultural Sciences is currently thinking about.

　　"At present, one of the main problems in corn production is that the level of mechanized harvesting of seeds is low. At present, the harvesting method is mechanical harvesting of ears or manual harvesting, which is not conducive to large-scale production." Zhang Zhijun, a researcher at the Corn Research Institute of Jilin Academy of Agricultural Sciences, said.

　　In recent years, the corn research institute of Jilin Academy of Agricultural Sciences has taken the research and development of new varieties suitable for modern production methods as its main research goal. "At present, we have cultivated Jidan 66, Jidan 436, and Jidan 81 and 82, which will be approved soon. It can be said that grain harvesting is a strong support for Jilin agriculture to take the lead in realizing agricultural modernization in the future." Lu Ming, deputy director of the Corn Research Institute of Jilin Academy of Agricultural Sciences, said.

　　Researchers overcome the difficulty of grain harvesting by machine (photo by Zhou Linhai from Yangguang. com)

　　Document No.1 of Jilin Provincial Party Committee issued this year made it clear that it is necessary to implement the project of improving corn yield per unit area. Screening and popularizing new maize varieties with density tolerance, high resistance and high yield.

　　"Every seed we develop must first ensure safety and good resistance. No matter what kind of environment, it can grow. The second is high yield, which allows farmers to increase their output after planting. " He Wei said. Hongxiang Seed Industry plans to reach the production capacity of all four design production lines as planned before 2025, meeting the production demand of 100,000 mu. "In the future, we can serve the whole park, let the seed industry in Jilin Province come back and build a spring corn processing base."

　　It is the wish of Jilin breeders to cultivate a good seed and plant a good field, and it is also the road they will always stick to.

　　Hongxiang seed industry farming field (photo by Yang Guangwang Fa Qu Liangliang)

　　According to Voice of China: Recently, Voice of China continued to report a secondary vocational school in Henan — — There are some problems in Henan Polytechnic School, such as forging student lists to obtain state education funds and renting state assets for illegal profits. In this regard, the staff of the Henan Provincial Department of Finance said that the school had previously had some expenses that were not uniformly registered and accounted for in the accounting books set up according to law, and that the school had been punished for privately storing public funds.

　　The Henan Provincial Department of Education said that it had been investigating and verifying the forgery of the student status list to obtain education funds, but it was unable to provide reporters with the list of students used by the school to apply for per capita funding. In fact, in recent years, the problems of enrollment, charging and management of secondary vocational education are not uncommon. Then, how to supervise the chaos in secondary vocational education?

　　Forged the student list, rented the teaching building, and the funds fell into the private "small treasury"

　　Informed sources told reporters that in recent years, there have been many students who dropped out of school early without completing their studies, and the school information still shows that they are studying at school. Based on this, the school has obtained the education funds allocated by the province.

　　Insider: "But what does it mean that students are still registered as students, and they are still registered as students?" That is, as soon as he registered, he handed it to the Education Department. This is not registered, and then this list was handed over to the Finance Department, and this student was dialed. "

　　The school staff provided the reporter with a list of 118 students who dropped out of two colleges early, and the Voice of China reporter verified them one by one. All the students in this list dropped out of school for different reasons in less than one year. However, most of the students’ information shows that they are still in Henan Polytechnic School.

　　Reporter: "Have you been studying in this Henan Polytechnic School for 16 years?"

　　Lost students: "Yes."

　　Reporter: "So you haven’t been there for a while?"

　　Lost students: "About a year."

　　According to the funding basis of the per-student funding of vocational schools in Henan Province, full-time vocational schools allocate funds strictly according to the number of students’ status, and the subsidies for different majors such as arts and sciences range from 5,000 yuan to 7,000 yuan per person per year. For those students who dropped out of school early, but their school status is still in school, the school theoretically received per capita funding.

　　In addition, many school staff reported that the school’s income from renting state assets including the comprehensive teaching building was not recorded, and the principal set up a "small treasury" privately.

　　The number of forgers and the allocation are still being verified, and the private small treasury is fined 10,000 yuan.

　　In response to this matter, the Voice of China reporter contacted the Henan Provincial Department of Education many times. The relevant staff of the Department of Education responded that the relevant situation has been investigated and verified, but the Department of Education does not have a list of students provided by the school to apply for per capita funding, and the funding is the responsibility of the financial department. The reporter then contacted the Henan Provincial Department of Finance, and the staff of the Department of Finance said that the financial department allocated funds according to the data provided by the education department.

　　Staff of the Finance Department: "We still record the number of students provided by the education department into our budget system, and determine its quota according to the number of students."

　　In addition, the staff of the Henan Provincial Department of Finance said that an administrative penalty of 10,000 yuan had been imposed in accordance with relevant regulations.

　　Expert: We should strengthen supervision and improve the funding system and methods.

　　In fact, in recent years, there have been incidents of false enrollment, arbitrary charges, and taking funds from secondary vocational education. In this regard, Wang Jianzhuang, executive dean and chief researcher of Henan Institute of Private Education, said that in addition to the main responsibility of the school, the living environment of secondary vocational schools, the utilitarian consciousness of individual schools and the official standard structure of vocational schools are all factors.

　　Wang Jianzhuang: "Because the competition for students is so fierce, some schools don’t run according to an educational law. Such a school, it tries to get funds through some improper means, and the per capita funding is the main source of funds for their school. Therefore, this will also have problems in system design, and this phenomenon will occur with some loopholes in supervision. "

　　Wang Jianzhuang believes that to completely change this situation, we need the joint efforts of the government, schools and other parties. While improving the quality of managers in secondary vocational schools, we should improve the funding system and methods, establish a mechanism to allocate funds to the extent that graduates serve the society, encourage the growth of high-quality secondary vocational education resources, and realize scientific development.

　　Wang Jianzhuang: "We use it to cultivate students’ other achievements, and its graduates serve the overall evaluation of society to allocate its funds in a planned way. For example, to evaluate a school and a secondary vocational school, there are 300 graduates this year. I will count the employment situation of your graduates through the graduates in the past five years, and I have an indicator of his contribution to the local economic and social development, and then I will give you the funds after this year in proportion, which is better. "

　　Voice of China will continue to pay attention to the progress of the follow-up investigation on this matter.

　　Yang Guang reporter Qian Cheng

Cancer is a big problem in the history of human medicine, and there is no way to completely cure it at present. In the face of cancer with extremely high mortality, life is fragile. No matter whether it is poor or rich, famous or unknown, we often see the news that celebrities have died of cancer, and we can’t help sighing, but there are also some wonderful experiences of anti-cancer success!　 Many cancer patients often lose confidence in life after learning that they have cancer, do not actively treat them, or even resist treatment, and feel that treatment is unnecessary, and treatment is a waste of money. In fact, this idea is not correct. Don’t give up until the last moment. Even if cancer has not been completely overcome, after scientific and reasonable treatment with many patients, life can be continued, and even clinical cure or long-term survival with tumors can be achieved! Nowadays, there are many treatments for cancer. If it is found as early as possible and treated actively, one third of cancer can be cured. Medical "cure" is different from what people usually understand. The clinical cure here refers to the disappearance of symptoms and signs after treatment, and the tumor can not be found after image review for more than 5 years.

Today, Xiaobian, a cancer-free home, will share the stories of four celebrities who have succeeded in fighting cancer, and see how they fight cancer. I hope to give some reference and motivation to all cancer friends!

Kai-Fu Lee: From the late stage of cancer to the disappearance of tumor, chemotherapy+targeted therapy against advanced lymphoma.

　 On September 5th, 2013, 52-year-old Kai-fu Lee, the founder of Innovation Factory, announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from. 　

Lymphoma, also known as lymphoma, occurs in the lymphatic system and is one of the malignant diseases of the blood system. In fact, we are no strangers. Besides Kai-Fu Lee, celebrities such as Luo Jing, Asan and Cindy Lee have also suffered from lymphoma. The incidence of lymphoma is actually not too high in malignant tumors, which is about 5/100,000. It can occur at any age, but it is mainly in middle-aged people aged 30-50. The malignant degree of different types of lymphoma varies greatly, which can be roughly divided into: inertia, aggression and high aggression. Inertial lymphoma is similar to chronic diseases, while high aggression is like a "death warrant"! There are many types of lymphoma, but as long as we know, lymphoma can be divided into Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL), the latter accounting for about 90%, and diffuse large B-cell lymphoma is the main type (40%~50%). When you know that you have stage 4 or systemic metastasis, it doesn’t mean that your condition is very serious and there is no cure. Don’t give up treatment easily. The treatment of lymphoma is mainly systemic chemotherapy and radiotherapy. Li Kaifu’s treatment plan is that bendamustine (bendamustine) is combined with rituximab (rituximab, trade name: rituximab). Different from traditional chemotherapy drugs, rituximab is called "an artifact to accurately combat lymphoma". It is an anti-CD20 monoclonal antibody against malignant B lymphocytes, with good effect and little side effects, and it is a milestone in the treatment of lymphoma. 　

Since rituximab was listed in the United States in 1999, the 5-year survival rate of patients with diffuse large B-cell lymphoma has increased to 50%. Rituximab used to be a self-funded drug, which was expensive. Now it has been included in the scope of medical insurance reimbursement, which has enabled many cancer friends to enjoy the fruits of modern medical progress.　　

In addition, Kai-Fu Lee also tried many kinds.Natural therapyIn order to finally defeat cancer.

Keeping a good sleep is the most important thing. Staying up late for a long time may reduce the body’s immunity, and his lymphoma is a common cancer in the immune system. Therefore, after suffering from cancer, he made a schedule to protect his immunity. It is necessary to keep your mouth shut when disaster comes from your mouth. It is particularly important for cancer patients to keep their mouths shut, and maintaining good eating habits can better fight cancer. Kai-fu Lee suggested that everyone should eat more grains, beans, fruits and vegetables, and take a balanced intake. 3. Take your legs apart and exercise properly to inhibit cancer cells. Many studies have confirmed that exercise is beneficial to the rehabilitation of cancer patients and can reduce the risk of cancer recurrence after operation. However, it should be reminded that not all exercise is suitable for cancer patients, and it is suggested to use the principle of "not feeling tired". 4. Good attitude, get twice the result with half the effort When fighting cancer, it is very important to keep a good attitude, which has a great influence on cancer treatment.

Pancreatic cancer: steinman "tried medicine by himself", and the dendritic cell vaccine made him live for four and a half years!

　 Speaking of vaccines, everyone is actually familiar with them, except for the common hepatitis B vaccine and influenza vaccine, and the Covid-19 vaccine that we have vaccinated up to now. In fact, cancer vaccine is also a form of immunotherapy, which can prevent cancer from developing or kill existing tumors by stimulating or restoring the human immune system. In the 21st century, the high incidence of cancer has attracted the attention of the global medical community. As a prominent tumor vaccine, dendritic cell vaccine has been a research hotspot in this field. When it comes to dendritic cell vaccine, we have to mention a legendary figure-ralph steinman, winner of the 2011 Nobel Prize in Physiology or Medicine. 　　

ralph marvin steinman After the diagnosis of pancreatic cancer in 2007, steinman actively tried a therapeutic vaccine (DC vaccine) based on dendritic cells. With the help of this "cellular immunotherapy", his life was extended from the expected months to four and a half years.　 There is a rule in the Nobel Prize that they never give this prize to people who have passed away. However, ralph steinman broke this rule because he passed away quietly three days before receiving the call for winning the prize. Therefore, Staman is also called the most regrettable Nobel Prize winner.

　 0one　　Suffering from pancreatic cancer with a mortality rate of 95%, he devoted himself to the research of DC vaccine.

In 1973, steinman discovered dendritic cells in the spleen of mice, and put forward the concept of dendritic cells. In 2011, steinman shared the Nobel Prize in Physiology or Medicine with Jules Hoffman and Bruce Beutler for "discovering dendritic cells and their role in the acquired immune system".

Pancreatic cancer, which claimed steinman’s life, is one of the malignant tumors with the highest mortality rate at present. The mortality rate of this disease can reach 95% clinically, and it is very rare for patients who can survive for 5 years after being diagnosed with this disease (< 5%). There is no approved cancer vaccine for pancreatic cancer, and the prognosis is very poor. The survival time of advanced patients is weeks or months. The disease is usually treated with the cytotoxic drug gemcitabine. However, this treatment seems to be mainly used for palliative treatment of advanced pancreatic cancer, which can improve the quality of life and prolong the median survival time of 5 weeks. Most patients will soon develop resistance to this drug. Therefore, the indomitable Professor steinman tried to use dendritic cell vaccine to treat his pancreatic cancer. Dendritic cells are the main antigen presenting cells (APC) in the immune system. They process antigenic substances (for example, from invading bacteria and viruses, and from cancer cells) and present antigens on their surfaces to other types of immune cells, especially T cells. This leads to antigen-specific activation of T cells. Therefore, dendritic cells act as the main link between innate immune system and adaptive immune system.　

02　　After eight treatments, dendritic cell vaccine made him live for four and a half years!

　 Professor steinman tried eight experimental therapies, one at a time. For each of these treatments, he and his colleagues submitted a single-patient use agreement to the FDA and obtained the approval of the agency. In these treatments, there are three kinds of cancer vaccines, and steinman finally used the dendritic cell vaccine from his own tumor instead of the cell line. Patients with advanced pancreatic cancer usually have poor prognosis. The median survival time of locally advanced and metastatic pancreatic cancer (advanced pancreatic cancer accounts for more than 80% of individuals diagnosed with the disease) is about 10 months and 6 months respectively. For all stages of pancreatic cancer, the 1-year and 5-year relative survival rates were 25% and 6%, respectively. However, Dr. steinman’s life span has been extended from several months to four and a half years! Since then, the medical community has launched a craze for the research and development of dendritic cell vaccines, which has become a kind of immunotherapy with more research and development achievements in recent years. At present, the dendritic cell vaccines approved by the FDA and many clinical trials entering the third phase are worth looking forward to. Since 2010, exceptThe FDA approved the first dendritic cell vaccine Provenge(sipuleucel-T) for the treatment of refractory prostate cancer. Dendritic cell vaccine has achieved good results in all kinds of cancer. Such as brain tumor-DC VAX-L vaccine, melanoma-—TLPLDC vaccine, renal cancer-—ilixadencel vaccine, newly diagnosed glioblastoma-AV-GBM-1 vaccine, lung cancer-CCL 21-dendritic vaccine, breast cancer -Her2 pulsed dendritic cell vaccine, etc.Xiaobian will not go into details here.

Nasopharyngeal Carcinoma: After 33 proton treatments, Li Zongwei successfully returned to badminton.

　 As the uncrowned king of badminton in the world, Li Zongwei, a famous Malaysian badminton player, has a brilliant career, with three runners-up in the Olympic Games, four runners-up in the World Championships, one runner-up in the soup cup and one silver medal in the men’s singles in the Asian Games. However, on July 25, 2018, he met another more powerful opponent-nasopharyngeal cancer. According to Malaysian media reports, Li Zongwei suddenly announced his withdrawal from the World Badminton Championships and the Asian Games badminton competition, and was later confirmed to have early nasopharyngeal carcinoma in September. However, Li Zongwei was not defeated by the disease. After 33 proton treatments of 25 minutes each time for more than two months, the doctor said that all the cancer cells in his body had been eliminated. In October of the same year, after he announced the success of anti-cancer, he said that he would return to badminton in December. Perhaps Li Zongwei is not a "winner" in badminton. Although he has won numerous titles, he has never won a world championship, including a slightly dismal record against Lin Dan. This time, however, in the face of this "competition" with the same disease, he finally won. This win will be the greatest capital of his life. In terms of treatment, it is difficult to perform radical surgery because of the special location and unclear boundary of nasopharyngeal carcinoma, the deep and narrow nasopharyngeal cavity, and many important blood vessels, cranial nerves and lymphoid tissues around it. But nasopharyngeal carcinoma is sensitive to radiotherapy, Therefore, radiotherapy is the main treatment for nasopharyngeal carcinoma, especially proton therapy. As the "king" of "precision radiotherapy", it can not only show its talents, but also effectively prevent the side effects of radiotherapy.

Proton therapy is a "qualitative leap" in tumor radiation!

　 Proton therapy is to accelerate the nucleus of hydrogen atom (i.e. proton) which has lost electrons to about 70% of the speed of light by using cyclotron or synchrotron. After being accelerated by the accelerator, protons with positive charges become very penetrating ionizing radiation, which enters the human body at a very high speed, is guided by special-shaped equipment, and finally reaches the targeted tumor site. Because of its high speed, the chance of interaction with normal tissues or cells in the body is extremely low. When it reaches a specific part of the tumor, the speed suddenly decreases and stops, and the maximum energy is released, resulting in a "Bragg peak", which can kill cancer cells without causing damage to surrounding tissues and organs.

　 　

When tumors are directly adjacent to important organs or structures, such as spinal cord, optic nerve and heart, proton therapy can still effectively treat tumors while protecting the functions of these important organs or structures, which is impossible in conventional radiation therapy.

　

The high radiation dose is concentrated in the tumor site, and there is no/little dose in the surrounding normal tissues.

　 　　

　

Legend: The radiation of Intensity Modulated Proton Therapy (IMPT) is mainly concentrated around the focus of nasopharyngeal carcinoma, with little or no influence on the surrounding normal tissues, while the radiation area of Intensity Modulated Radiotherapy (IMRT) is large, covering the focus and surrounding normal tissues.

Melanoma: "cured" after 4 months, immunotherapy made Carter the "longest-lived president"

　 In August 2015, former US President Carter was diagnosed with malignant melanoma, and liver metastasis and brain metastasis have occurred, so he is an out-and-out terminal patient. But just four months later, at an event in December, 91-year-old Carter announced that he had just confirmed after a general examination that the lesions in his body had disappeared. 　

It is understood that Carter used comprehensive therapy. First, the visible tumor was surgically removed, then the intracranial tumor was treated by radiotherapy, and finally the PD-1 drug Keytruda of Merck was used. After the brain cancer cells disappeared, Carter said that he would continue to use Keytruda for treatment. This incident made immunotherapy popular all over the world overnight. PD-1/PD-L1 and CTLA-4 pathways are crucial to the immune system’s ability to control cancer growth. These pathways are often called immune checkpoints. Many cancers will use these ways to escape the immune system. Specific antibodies to immune checkpoint inhibitors can block these pathways to deal with cancer. Once the immune system can find and deal with cancer, it can stop or slow down the development of cancer. Having said that, I have to mention the biggest difference between immunotherapy and traditional treatment, that is The trailing effect of immunotherapy, that is, patients who benefit from immunotherapy can continuously obtain stable results and bring long-term survival.

This article is original for a cancer-free home, and it needs authorization to reprint.