1905 movie network news　Last weekend (01.18-01.20), the box office revenue in North America totaled $129 million, up 8.2% from the previous week. Monday is Martin Luther King Memorial Day, and we will continue to have a holiday. Among the new films on the list, M Knight Shamalan’s new film "Mr. Glass" earned $40.58 million in the first three days of the first weekend, which was close to $40.01 million in the first week of "Split" in 2017 and higher than $30.33 million in the first week of "Never Die" in 2000. Not surprised or pleased. The media mostly think that the content is too full and too anxious, but there is no emotional touch. They think that they are not attracted to fans of "The Dead Robber" or "Split" and become ungrateful at both ends. Another new film is a slightly niche animated film "Dragon Ball Super: brolly". The plot is based on the animated series "Dragon Ball". After telling the story of Wukong and brolly, it is biased towards fans. In the first week, it won 10.65 million US dollars in 1233 theaters in North America, but it attracted a limited audience and was not optimistic about its subsequent box office development.

"Mr. Glass" is too full of word of mouth, and the fans of "Dragon Ball Super: brolly" are serious

Recommended star rating of Mr. Glass: ★★★

"Dragon Ball Super: brolly" Recommended star rating: ★★★ (specific fan direction)

On the weekend of Martin Luther King’s Day, M Knight Shamalan’s new work "Mr. Glass" earned 40.58 million US dollars at the box office in North America from Friday to Sunday, which was close to 40.01 million US dollars in the first week of "Split" in 2017 and higher than 30.33 million US dollars in the first week of "Never Die" in 2000. In all the Martin Luther King Memorial Weekends, this box office ranked third, only behind the $41 million of "Sasaki Brothers" in 2014 and the $89 million of "American Sniper" in 2015. The production cost of Mr. Glass is $20 million, and the global box office has reached $90 million. These figures undoubtedly prove Shamalan’s ability to make money again. In fact, even in the low tide of Shamalan’s poor reputation, many of his films were very profitable. For example, in 2008, the production cost of "Death" was 48 million US dollars, and the final global box office was 163 million US dollars. In 2004, the production cost of "Mystery Village" was 60 million US dollars, and the final global box office was 256 million US dollars. What he really didn’t earn was only.

At present, the cinema score of Mr. Glass is B, IMDb score is 7.2, MTC score is 42, and the freshness of rotten tomatoes is 36%. "Hollywood Reporter" commented: "As the final part of the trilogy, this film is like a mixed bag, twisting all the previous narrative clues into one, but unfortunately trying too hard to tell the audience that Shamalan has a very special idea on the popular comic adaptation story, but the result is not shown." "Variety" said: "It’s still very happy to see Shamalan return, but" Mr. Glass "takes up more of our time, but it can’t create any touches, which makes people feel busy and dazzling, but there are few moving moments of emotional resonance." "International Screen" thinks: "Apart from McEvoy’s performance as a smoke bomb and Bruce Willis’s convincing charm, the whole film has actually not gone far in the concept of’ what happens when people become superheroes’." Due to the poor reputation, the follow-up box office track of Mr. Glass may be more similar to the Clover Files, which was opened on the weekend of Martin Luther King’s Day in 2008. The film earned $40 million in the first week and $80 million in the local box office.

Another noteworthy new film last weekend was the classic IP cartoon "Dragon Ball Super: brolly", which was only opened in 1,233 theaters in North America, aiming at clearly attracting a specific fan base, and won $10.65 million at the box office in three days in the first weekend. The story of "Dragon Ball Super: brolly" is a continuation of the upcoming TV animation "Dragon Ball", which tells the story between Saiyan brolly and Wukong. The film was nominated for the best cartoon in the 42nd Japanese Film Academy Award and was very popular among fans. At present, the media scores and fans’ scores of all platforms are very high, with IMDb score of 8.6, MTC score of 64 and the freshness of rotten tomatoes of 80%. The Los Angeles Times said: "brolly is ready to give Dragon Ball fans everything they want in a movie, and other viewers may feel lost in this world." Midwest Film Journal also thinks: "For the novice Dragon Ball, this film provides a dazzling animation time." There are also some media that don’t like it, such as "Movie Country", which means: "This is a meaningless garbage culture animation only for fans."

Old movies: "Neptune" local over 300 million "Upward" has a strong box office stamina.

Warner Bros.’ s superhero movie Neptune has entered its fifth week. After the weekend, the film’s box office outside North Captain America: Civil War has reached 759 million US dollars, surpassing’s 745 million US dollars, and the local box office has also exceeded 300 million US dollars. At present, the film’s global total box office is 1.063 billion US dollars, which is still 3 million US dollars short. Amber Heard’s Neptune can surpass Johnny Depp’s highest-grossing Pirates of the Caribbean: The Coffin. At the same time, Aquaman is also the movie with the strongest box office stamina after Teenage Mutant Ninja Turtles: The Age of Mutations in 2014. It is expected that Aquaman will have a good room for growth before The Lego Movie 2: The Second Part and Listen to Men’s Hearts come out on February 8.

In the following week, Upward Bound kept quite steady, with the box office of $15.6 million in three days over the weekend, which was only 23% lower than that in the first week. Earlier, many films in kevin hart fought bravely in Martin Luther King’s weekend, such as the above-mentioned Sasaki Brothers, Customized Best Man and Sasaki Brothers 2, and so on. This time, Upward Bound was opened in this schedule one week ahead of schedule. At present, the total box office of Upward is US$ 43.98 million. As long as it exceeds the US$ 48.7 million of Supersize Beauty last year, it will become the third domestic box office of STX Entertainment after bad mother and Christmas of Bad Mom. Sony’s Spider-Man: Into the Spider-Verse currently has a global box office of US$ 322 million, which has surpassed The LEGO Batman Movie’s US$ 311 million. The production cost of Spider-Man is US$ 90 million.

This week’s preview: Adventure "King Boy" Playing through the thriller "Quiet" arouses expectations.

This weekend (01.25-01.27), Fox’s youth movie "King Boy" and Matthew McConaughey and Anne Hathaway’s crime thriller "Quiet" will be widely opened in North America.

Fox’s "The King’s Boy" tells the story of a little fat boy, Alex, who accidentally pulls out and passes on the "sword in the stone" mentioned by H. As a destined little hero, he needs to unite his friends and the legendary wizard Merlin to fight against the eccentric witch Morgana. This is a story from modern times to legend, which will be opened in more than 3,400 theaters in North America this Friday. The crime thriller "Quiet" starring Matthew McConaughey and Anne Hathaway was postponed from last October to this week. It tells the story that Baker Dill, the captain of a fishing boat, received a request from his ex-wife Karen to help her kill her violent current husband. Karen’s appearance was forgotten in Jandyr, but in fact, the current situation is also city by the sea. The film will open in more than 2500 theaters this Friday.

　　Yangguang. com BeijingsixmoonfiveJapan News (Reporter Sun Bingjie) Recently, a new type of Internet has emerged in Shandong and Fujian.+Home-based medical model-"shared nurses" has aroused public discussion. This one is connected to the Internet.+The new medical model of hitchhiking not only brings convenience to patients, but also causes social doubts about its safety. National Health Commission, as the competent department, responded a few days ago and will summarize the experience of "sharing nurses" in various places to guide the standardized development.

　　"shared nurses": a win-win situation for nurses and patients?

　　Bike-sharing, familiar with the public, etc.APPSimilarly, turn on the phone.APPChoose the service you need, place an order, wait for the platform to screen, and you can enjoy the services provided by nurses or doctors in just ten minutes. This is a "shared nurse" model popular in Jinan, Shandong and other places recently.

　　"shared nurse"APPWhat services can you provide? The reporter downloaded an earlier one with the words "shared nurse" on the mobile phone.APPBesides routine injections, infusions, blood collection, etc., its homepage can also provide services such as catheterization, enema, stitches removal and maternal and child care.

　　This new type of "Internet"+The mode of "home care" is being welcomed by many users, such as Ms. Wan Juan in Beijing.APPA loyal user of. She told reporters that her family is old and young, and she rarely has time to go to the hospital.APPSolved her "trouble" to a great extent. "I have to queue up when I go to the hospital to register. The elderly and children at home are uncomfortable. I now make an appointment with doctors and nurses directly."

　　At present, the shared nurses launched by various platformsappThere is little difference in functions, mainly providing on-site service for nurses. In addition to the top three hospitals, some nurses come from outpatient departments of primary hospitals. The service items are varied, but mainly include injection and infusion, dressing change and maternal and child care.

　　Compared with public hospitals, the reporter noticed that nurses were shared.APPIt is generally expensive in price. Take basic services such as infusion and injection as an example. Most of themAPPOn-site service price is at150About yuan, more than hourly billing. According to the price of medical services in public hospitals in Beijing(2017edition),Adult outpatient intravenous infusion general public hospital price insevenYuan or so, only this one is close.twentyTimes.

　　However, in the view of employee Zhao Fei, the current pricing is still in the "acceptable range" compared with the cost of patients queuing in the hospital. And the shared nurse model can not only provide convenience for patients, but also give patients and nurses appropriate subsidies, which can increase the income of nurses.

　　"Now nurses pay more, but their income is not ideal. In particular, some nurses are too old to work at night, and theseAPPIt provides them with opportunities to realize their skills and increase their income. Yang Jie, a nurse in a hospital in Xicheng District, Beijing, told reporters.

　　"Aging" gives birth to the demand for home care

　　In fact, shared nursesAPPIt is not the first time that it has appeared. The upsurge of sharing economy in recent two years has also made the medical field the next outlet. Huge nursing demand and professional nursing force through "Internet"+"Shared nurses" are entering the families of ordinary people.

　　The latest statistics of the National Office for Ageing, as of2017At the end of 2008, the whole country60The number of elderly people over the age of2.4Billion, accounting for the proportion of the total population.17.3%, average nearfourIndividual labor supportoneAn old man. Many elderly people suffer from chronic diseases and need regular health care; Among the hospitalized patients, at least20%~30%% of patients still need nursing after discharge.

　　There is a strong demand for nurses’ home service. Mobile nursing platform provides opportunities for nurses to realize their skills. While "shared nurses" seem to be "win-win", the unsafe factors can not be ignored, mainly focusing on nurse qualifications, medical safety and so on.

　　According to National Health Commission2008The Measures for the Administration of Nurses’ Professional Registration, which was implemented in, stipulates that nurses can only engage in nursing work according to the registered practice place after obtaining the Nurse’s Practice Certificate through practice registration. According to the reporter’s understanding from National Health Commission, at present, except for Beijing, Tianjin and Guangdong, which are pilot areas for regional registration of nurses, nurses in most other provinces have no multi-point qualification.

　　"This means that the on-site service is actually carried out outside the registered practice place and is suspected of illegal practice." Analysis of Zhou Xuefeng, a lawyer of Beijing Jingshi Law Firm.

　　In addition, how to avoid the medical risks in the nurse’s home service center? It is the key to whether the "shared nurse" platform is reliable. The reporter noticed that the current shared nursesAPPFor patients with higher risks, they will generally not take orders, and nurses will also choose orders with lower risks. Yang Jie, who has many years of nursing experience, admits that the biggest risk of door-to-door infusion lies in its uncontrollable nature, and patients may have adverse reactions during infusion. The patients’ families lack emergency rescue equipment, "not only the patients will be very dangerous, but also the disputes between doctors and patients will be difficult to sort out."

　　Relevant policies are on the way.

　　this yearfourmoon28On April 20, the General Office of the State Council officially released "On Promoting the Internet"+Opinions on the development of medical health. Require a sound "Internet"+Medical health "service system. Promote the integration of Internet and medical and health services from the aspects of medical treatment, public health, family doctor signing, drug supply guarantee, medical insurance settlement, medical education, popular science and artificial intelligence application. It covers many aspects of medical treatment, medicine and medical insurance.

　　In an interview with a reporter from the Central Broadcasting Bureau, the relevant departments of National Health Commission pointed out that some provinces and cities with conditions have explored the "shared nurse" door-to-door service, which has solved the problem of the elderly and patients with mobility difficulties, brought convenience to the people, and is an exploration of nursing service entering the family.

　　According to the forecast of the World Health Organization,2050In, China will have.35%The population of more than60Years old, which means that China is also facing strong aging pressure under the background of building a well-off society in an all-round way. In Zhao Fei’s view, aging+The limited medical resources have created many urgent needs for Chinese to see a doctor at home. "Although the’ shared nurse’ has some flaws, it has responded to some extent.The basic desire of "seeing a doctor at home". Wu Zhipan, a professor at Peking University, said, "Most norm makers are facing the Internet.+"Mode, it is inevitable to behave behind some, should set aside time. "

　　Regarding whether it is legal for nurses to sign contracts with the online platform, the relevant authorities said in an interview that the multi-point practice of signing online platforms and physical medical institutions is not the same, but there is no relevant policy. National Health Commission said that the next step will be to gradually revise and improve the policies related to nurse practice management on the basis of summing up the pilot experience, combining with the promotion of graded diagnosis and treatment and the continuous deepening of medical reform. At the same time, further implement the "General Office of the State Council on promoting the Internet"+Opinions on the development of medical health, combined with the experience of exploring and developing "shared nurses" in various places, guides standardized development to meet the diversified and multi-level health needs of the public.

　　Cctv newsToday (August 30th), Zhang Ying, director of the Employment Promotion Department of the Ministry of Human Resources and Social Security, answered a reporter’s question about youth employment at a policy briefing in the State Council, saying that young people are the most active and dynamic force in the whole society, and there is great potential for innovation and creation. Promoting youth employment is related to the improvement of people’s livelihood, high-quality development and the future of the country. The 14th Five-Year Plan for Employment Promotion not only emphasizes the continuous employment of college graduates, but also clearly puts forward the promotion of youth employment for the first time and makes separate arrangements.

　　Zhang Ying said that the overall consideration is to promote youth employment and entrepreneurship through multiple channels through the efforts of the supply and demand sides and the support of policy services. The specific measures are as follows:

　　First, focus on creating diversified employment opportunities.Expand employment and entrepreneurship opportunities in new industries, new formats and new modes, connect with the optimized industrial layout, coordinated regional development and the talent demand of enterprises in key industries, improve the demand forecasting, factor allocation and coordinated development mechanism of human resources, and support young people to find jobs and start businesses in areas that are in urgent need.

　　The second is to enhance the ability of career development.Improve the job-seeking ability through career guidance, increase the guidance of career planning, career experience and job-seeking methods, and enhance the adaptability of young people in the workplace. Through vocational training, improve professional skills, expand special ability training, new vocational training, and replace training with work to enhance the growth of youth employment. Increase practical experience through employment internship, provide more internship opportunities for management and technical positions, and enhance the post competence of young people.

　　The third is to focus on enhancing the pertinence of employment services.We will improve the employment service model that meets the needs of young people, and provide employment services such as job introduction according to their employment wishes, so as to improve their accuracy in choosing jobs. Open the channels of information services, organize professional and professional recruitment activities, combine online and offline, and innovate more employment service models such as "live broadcast with posts" that meet the characteristics of young people.

　　The fourth is to focus on helping the difficulties.We will implement the youth employment sailing plan, provide practical guidance, classified guidance and follow-up assistance to unemployed young people, and guide them to stand on their own feet and enter the market and integrate into society. At the same time, we will provide employment assistance to some unemployed young people who are in difficulty and secure the bottom line of employment.

　　College graduates have always been the most important among the youth groups. For recent college graduates, the Plan has defined a special employment and entrepreneurship support plan to continuously expand market-oriented and socialized employment channels. For previous unemployed graduates, they can also get better support through relevant measures and arrangements to promote youth employment.

　　Zhang Ying said, we will do our best to create conditions for young people to find jobs and start businesses, and help them contribute to the country with their wisdom and talents, so as to forge ahead and serve the society.

On February 9th, Mary, the actor who made his eighth appearance on the stage of the Spring Festival Evening, came to the interview room. She said that every time she comes to the Spring Festival Gala, like the exam, she is particularly nervous and under great pressure. When she has good works, she will be more confident in acting, but this year’s time is relatively hasty.

Mary said that it is actually more difficult for an actress to act in comedy than an actor, because she is not willing to "sell" or "play", but rather wants to start from the characters, so whether it is the structure or the character of the role, it is still more challenging to act.

Talking about the upcoming film Article 20, Mary said that he didn’t expect to cooperate with director Zhang Yimou one day. From the day he joined the group, he felt that everything was like a dream. Mary also said that Zhang Yimou’s state of filming on the spot, his unique ideas, his requirements for actors and his control of all the plays made him feel that the director is the most attractive and soul person in the crew and the soul of a movie. "I think the director is like a god to me."

Recalling that in 2023, Mary admitted that he was a model worker. Last year, there were 3 or 4 films and played some very powerful female roles. The creative process was happy, but it was also very painful. The result was very satisfactory for himself. I hope I can give myself a holiday in the new year.

autoplay

Air-conditioning, watermelon, and WiFi are essential for summer homes.

Online classes, playing games and watching videos have become the daily life of friends.

Recently, there is a small partner private letter Xiaobian.

I found that my mobile phone traffic was "secretly running"

"The mobile phone is clearly connected to WiFi for 24 hours.

Why do you still generate traffic data? "

In order to protect the "money bag" of friends.

Xiaobian, this will reveal the secret for you.

Two misunderstandings

1. Some friends think that after the WiFi connection is successful, there is no need to turn off the data traffic. In fact, when the WiFi signal is unstable, it is still possible to consume traffic.

2. Some friends think that the mobile phone is still running traffic when connected to WiFi, which is either a problem with the mobile phone or a bug in the traffic. In fact, there is a problem with the mobile phone traffic settings.

1. When the WiFi is unstable or disconnected, the mobile phone may switch back to the 2G/3G/4G/5G network by default;

2. Some public WiFi has a time limit and will automatically switch back to the data network after the use time is over;

3. Due to the problem of mobile phone settings, WiFi； connection failed;

4. Some mobile phone systems will automatically switch to the data network when the WiFi connection signal is weak.

solution

1. Turn off the mobile data when connecting to the WiFi network.

2. Many smart phones will automatically open the data network when the WiFi signal is weak by default, so we’d better turn this function off.

Android system (take Huawei mobile phone as an example): Click "Settings-WLAN-WLAN+"to close it.

IOS system (for example, iOS9 and above): Click "Settings-Cellular Network-WLAN Assistant" to close it;

3. When the mobile phone is set to WLAN connection disconnection, it will prompt to use mobile data connection, such as Android system (taking Huawei mobile phone as an example), and click "Settings-Mobile Network-Mobile Data-Advanced-WLAN/Mobile Data Connection Switching Prompt-Prompt to Use Mobile Data Connection".

Today’s mobile phone traffic secrets are shared here!

Have you learned?

If you find it useful

Original title: "Traffic is" sneaking "? The truth is coming … "

Read the original text

10moon17The 9th china international forum on work safety Fire Safety Sub-forum, hosted by the Fire Rescue Bureau of the Ministry of Emergency Management and undertaken by the China Fire Protection Association, was held in Hangzhou, Zhejiang. Experts and scholars from domestic and foreign fire protection fields had in-depth exchanges around "strengthening fire accident prevention and promoting the development of fire protection". Zhou Tian, Chief Engineer of Fire Rescue Bureau of Emergency Management Department, presided over the sub-forum, and Chen Weiming, President of China Fire Protection Association, attended and delivered a speech. Responsible persons of fire departments of fire brigades, responsible persons of fire research institutes and fire product conformity assessment centers, as well as representatives of relevant scientific research institutions, research institutions and enterprises.300More than 200 people attended the sub-forum, and at the same time, the Japanese Fire Protection Association, national fire protection association, the International Federation of Fire Protection Associations and German were invited.VDSExperts and scholars of certification bodies.

Zhou Tian said that this forum is the first large-scale international forum held after the establishment of the Emergency Management Department. During this period, a sub-forum on fire safety was established for the first time, which fully reflected the concern and attention of the Emergency Management Department to the fire-fighting cause and the integration and docking of fire-fighting work and safety production work.

Chen Weiming said in his speech that as the organizer of this china international forum on work safety fire safety sub-forum, it is very meaningful for China Fire Protection Association to provide a high-standard communication platform for fire professionals from all corners of the country.

This sub-forum on fire safety invited domestic fire departments, scientific research institutes, universities, fire-fighting enterprises and fire-fighting experts and scholars from overseas to hold.14The keynote speech included not only the latest achievements in fire risk analysis and prevention and control technology research of high-rise and underground buildings, petrochemical enterprises, large-scale urban complexes and new energy vehicles, but also smart fire protection construction, external wall insulation materials, fire accident investigation, volunteer fire brigade management and certification of domestic fire protection products entering overseas markets, which are all hot, difficult and focus issues in current fire safety work.

Participants in the sub-forum said that it is very rare for Chinese and foreign counterparts to have such an exchange opportunity. Through one day’s discussion and exchange, they not only enhanced mutual understanding, but also enhanced cooperation and friendship, and gained a lot.

CCTV News:During the harvest season, many new farmers are active in the vast fields. They are using newer ideas, better technology and more scientific management mode to change the traditional agricultural planting methods and harvest their own "bumper life".

PPT will be put on first in the meeting. Data and flow are high-frequency words that pop up from time to time in the discussion. You may not think that this group of young people with an average age of less than 29 are actually dealing with land every day.

Li Ting is the head of this team. After graduating from Jiangxi Agricultural University in 2015, she went to an eco-agricultural company in Guangdong. At the end of 2016, Li Ting resigned and returned to his hometown Yingshang County, Anhui Province to start a business.

Compared with the traditional farmers facing the loess and facing the sky, Li Ting’s team is labeled as a "new farmer". The 11 members are all university graduates, including those who study agriculture, finance and journalism. In Li Ting’s view, their advantage lies in making good use of data to guide farming.

Data becomes new agricultural materials to help traditional agricultural production

Then, how did Li Ting and his team apply the new agricultural material "data" to farming? Let’s continue to read the report.

The cycle of crop growth, the change of market conditions, the performance of sales terminals and the portrait of customer groups are as important to Li Ting and his team as seeds, fertilizers and pesticides. At present, this 200-acre spinach is just the harvest that Li Ting and others "grabbed" with data. Before, because of the continuous high temperature, the sprouting rate of edamame was not good even after two crops were planted in the field, and it was about to be harvested.

In order to make good use of data, a new agricultural resource, Li Ting has set the development direction of "market-oriented, order-based planting". Although the planting structure of seedlings of pepper, chestnut pumpkin, Trichosanthes kirilowii and cauliflower has been adjusted, it can ensure that all the seedlings are "explosive". There are jobs in the greenhouse all year round, and more than 60 villagers have a relatively stable job.

The action of "two strengths and one increase" helps new farmers "wisdom" to cultivate land

In order to further improve the efficiency of vegetable planting, Li Ting and others are going to upgrade the previous greenhouse, but the upfront investment in facility agriculture is very large, and the cost of upgrading the digital greenhouse is even higher. How did they solve the problem of funds?

Just when Li Ting’s team was at a loss for funds, Anhui Province launched the action of "strengthening agriculture by science and technology, strengthening agriculture by machinery and increasing farmers’ income", providing a series of policies and financial support for digital agriculture projects.

With the support of various policies and funds of the local government, Li Ting’s base has gradually established a digital seedling factory, a cold storage room, a movable seedbed, an automatic sprinkler system and a visual Internet of Things system. These "new farm tools" exchanged for real money have made farming more scientific and technological and easier.

Just last year, Li Ting became a science and technology correspondent in Yingshang County, and his base has also become a local exhibition area for promoting modern agriculture. Almost every week, people come to visit and study.

Digitalization empowers new farmers to become farmers.

Li Ting and his friends have used what they have learned to become new farmers, realizing their own value and driving more and more people around them.

At present, the planting base of Li Ting has grown to 560 mu, and the surrounding planting area is 3,000 mu driven by radiation. Everyone knows that following Li Ting, there is no need to sell vegetables.

In the past two years, in addition to the flourishing facilities vegetable project, Li Ting and his team have successively transferred more than 2,000 mu of cultivated land, planting staple foods such as rice and wheat. Growing vegetables and raising seedlings, they already have rich experience and stable sales channels. Why should they go out of the comfort zone? Li Ting’s goal in mind is not small.

Li Ting, head of Anhui Yingshang Shili Ecological Agriculture Technology Co., Ltd.:We do field crops mainly based on the consideration of "digital" farmland, and we want to digitally empower in the field. At the same time, there is no need to panic when we have food in our hands, and the issue of national food security is also our responsibility as a new farmer.

Since March 2021, the influenza activity in southern and northern provinces has been higher than that in the same period in 2020, and since September, the level of influenza activity in southern provinces has shown an obvious upward trend. The risk of overlapping epidemic of COVID-19 epidemic and influenza and other respiratory infectious diseases still exists this winter and next spring. Recently, it coincided with a large-scale cooling in China, and the flu vaccine quickly "warmed up". However, how to choose a flu vaccine that suits you?

I. Types of domestic influenza vaccines

At present, there are trivalent inactivated influenza vaccine (IIV3), tetravalent inactivated influenza vaccine (IIV4) and trivalent live attenuated vaccine (LAIV3) approved for marketing in China.

Among them, trivalent influenza vaccine is suitable for children and adults over 6 months, which can prevent influenza caused by two influenza A viruses (H1N1, H3N2) and one influenza B virus (Victoria).

Four-valent influenza vaccine has more protection against one type of influenza B virus (Yamagata) than three-valent influenza vaccine, but the current four-valent influenza vaccine in China needs to be over 3 years old to be vaccinated.

Second, the way of influenza vaccine administration

At present, there are two ways to administer influenza vaccine in China, one is traditional injection and the other is nasal spray.

Among them, the nasal spray method is unique to the nasal spray influenza vaccine, which was only listed in China in August 2020, but it is not the first in China. It has existed abroad for a long time (the United States and the European Union approved the use of nasal spray influenza vaccine in 2003 and 2012, and both of them are tetravalent), but the market share has not been high. This vaccination method can effectively avoid puncture and "needle fainting" caused by injection, but as for whether it can really make children not afraid of getting flu vaccine, it seems that it is not. Although it doesn’t seem to hurt, the nasal mucosa is also very sensitive, and the way of "nasal spray" is not necessarily more comfortable than intramuscular injection. It is difficult for children to ensure the accuracy of vaccination dose, and the technical operation requirements for vaccinators are relatively high.

Third, the safety of influenza vaccine

Influenza-like vaccines are all split or subunit, that is, inactivated vaccines. After years of practice, the safety of all kinds of inactivated vaccines is relatively high. Its contraindications are limited to allergies to vaccine ingredients, and there is no restriction on egg allergies. Even during pregnancy and some elderly people with basic diseases are recommended to be vaccinated.

Then let’s take a look at the new nasal spray influenza vaccine: this vaccine simulates the process of natural influenza infection. After the vaccine is atomized, it enters the body through the nasal cavity, and the first barrier is mucosal immunity, and then cellular immunity and humoral immunity are generated by activating lymphocytes. However, this means that the nasal spray vaccine must be an attenuated live vaccine. From the point of view of safety, attenuated live vaccine may expel vaccine virus strains after inoculation, and occasionally it is reported that the live virus discharged from the vaccinator is transmitted to the uninoculated. Therefore, it is not recommended to vaccinate children with severe immunocompromised patients with nasal spray influenza vaccine.

Relatively speaking, the live attenuated vaccine has more contraindications (rhinitis, asthma, immune problems, etc.), and the range of people who can be vaccinated is narrower. The vaccination age range of this vaccine is 3-17 years old, which directly avoids children under 3 years old and the elderly who may have basic diseases. Pregnancy is also a contraindication. Even people who have used anti-influenza drugs such as oseltamivir and zanamivir (or traditional Chinese medicine with antiviral components) 48 hours before vaccination are not recommended to be vaccinated with this nasal spray vaccine.

Some foreign researchers have summarized the cases of influenza still diagnosed after receiving nasal spray vaccine or attenuated live vaccine or inactivated vaccine for injection. Among 17,173 patients aged 2-17, 4,579 received inactivated vaccine by injection, 1,979 received nasal spray vaccine or live attenuated vaccine, and 10,615 were not vaccinated. It was found that the effectiveness of inactivated vaccine for injection against influenza A (H1N1) was 67%, and the effectiveness of nasal spray vaccine or attenuated live vaccine was 20%. Compared with the recipients of inactivated vaccine by injection, the probability of infection with influenza A (H1N1) is significantly higher among those vaccinated with nasal spray vaccine or live attenuated vaccine.

Fourth, the effectiveness of influenza vaccine

As far as the effectiveness of protection scope is concerned, the tetravalent influenza vaccine containing four influenza virus strains (two types A and two types B) is better than the trivalent influenza vaccine containing three influenza virus strains (two types A and one type B).

Based on five studies from 2013 to 2016, the effect of nasal spray vaccine or live attenuated vaccine on influenza A (H1N1) is lower than that of inactivated vaccine by injection in all children’s age groups. Therefore, the American ACIP (Advisory Committee on Immunization Practice) did not recommend nasal spray influenza vaccine in 2016-2017 and 2017-2018.

A meta-study published online in Pediatrics in January 2019, entitled "Live Attenuated and In Activated Influenza Vaccination Effectiveness", recorded the reasons (and reviewed Meta) why AAP and CDC did not recommend nasal influenza vaccine in 2016-17 and 2017-18.

Please see the figure below for a detailed comparison list.

(Click to view larger image)

Finally, to sum up:Under the age of 3, there is no choice but to get trivalent flu vaccine. Above 3 years old, tetravalent vaccine is definitely the first choice in terms of protection effect. However, the price of trivalent vaccine is half cheaper than that of tetravalent vaccine (50 yuan VS110 yuan). If the money is not bad, then choose tetravalent vaccine. As for the nasal spray vaccine, if you are over 3 years old and under 17 years old, you happen to be "dizzy" or have extreme fear of injection, then it is much better to vaccinate the nasal spray vaccine than to do nothing.

　References:

1.Chung JR, Flannery B, Ambrose CS, Bégué RE, Caspard H, DeMarcus L, Fowlkes AL, Kersellius G, Steffens A, Fry AM; Influenza Clinical Investigation for Children Study Team; Influenza Incidence Surveillance Project; US Influenza Vaccine Effectiveness Network. Live Attenuated and Inactivated Influenza Vaccine Effectiveness. Pediatrics. 2019 Feb; 143(2):e20182094. doi: 10.1542/peds.2018-2094. Epub 2019 Jan 7. PMID: 30617239; PMCID: PMC6361354.

2. Yang Penghui, Yang Lufang. Study on immune defense mechanism of respiratory mucosal infection of influenza virus. International Journal of Immunology, 2006,72(5):294-298.

3. Technical Guide for Influenza Vaccination in China (2020-2021)

4.https://www.cdc.gov/flu/prevent/nasalspray.htm

5 Changchun 100 grams of biological nasal spray attenuated trivalent influenza vaccine instructions

Successful listing does not mean that you can sit back and relax. How to make the brand develop for a long time after listing is the beginning of the test.

This article was originally published by Hongcan.com (ID: hongcan18), by Jian Yuhao; Editor: Jing Xue.

On April 23rd, Chabaidao (2555.HK) was officially listed on the main board of the Hong Kong Stock Exchange. However, the performance on the first day of listing was not ideal. On the morning of 23rd, Chabaidao opened at HK$ 15.74 per share, which was lower than the issue price of HK$ 17.5. At the close, Chabaidao recorded HK$ 12.80 per share, with a market value of only HK$ 18.914 billion. In intraday trading, the share price of Chabaidao once fell to HK$ 10.80/share.

Time goes back to a week ago. On April 15, the first day of the public offering of Chabaidao, it attracted attention because the public offering did not achieve full subscription. In addition, at that time, Chabaidao did not introduce cornerstone investors. Many investors have said that if a company with a valuation of tens of billions does not introduce cornerstone investors, it may mean that the valuation of this enterprise is too expensive, or institutional investors are not optimistic about the future profit prospects of the enterprise.　

Although it was successfully listed, there are different opinions in the industry about "the second share of new tea". On the one hand, the successful listing is a milestone achievement for Chabaidao. However, in the eyes of some people in the industry, listing is not once and for all. In the increasingly competitive new tea circuit, there are still many uncertainties in the future development of Chabaidao.　

After 01.80, the couple sold milk tea with a net worth of over 14 billion.

According to public reports, the founder of Chabaidao, Wang Xiaolong, and his wife, Liu Yuhong, were both born in the 1980s. Wang Xiaolong was a senior tea artist and his wife was a tea lover. Because they have accumulated rich tea knowledge and practical experience in their past work and life, they started the entrepreneurial experience of a tea shop.　

In 2008, near Wenjiang No.2 Middle School in Chengdu, Sichuan, the first Chabaidao opened. This store, which is less than 20 square meters, is mainly for students with low spending power, and mainly sells powdered milk tea in the form of foreign belts.　

At that time, compared with the hot demand of portable brewing milk tea, the existing tea was still in its infancy. The emergence of "Tea Hundred Ways" just fills this blank. With good products and affordable prices, it has successfully attracted the attention of students’ consumer groups. The blank of the market itself, coupled with the advantages of site selection, enabled Wang and his wife to successfully earn the first bucket of gold. A year later, they opened a second branch on the campus of Southwestern University of Finance and Economics (Liulin Campus).　

In 2010, the trademark "Tea Hundred Roads" was officially registered. In the same year, two major desktop milk tea brands, Diandian and coco, successively entered the mainland for development. In the following years, a number of existing tea brands such as Xicha, Lujiao Lane and Naixue Tea began to rise, and new Chinese tea officially entered the stage of branding and chain development.　

△ Image source: Chabaidao official little red book　

In 2016, Chabaidao opened its franchise in Chengdu for the first time, upgraded its stores and started its brand operation. This year, the number of stores in Chabaidao exceeded 100.　

Generally speaking, the development speed of Tea Hundred Roads in the early stage is not fast, and the sense of existence is not strong.　

It was not until 2018 that this situation began to change. This year, Chabaidao began to aim at the whole country, which opened the expansion of the whole country, and the rapid growth of Chabaidao began to enter the investor’s field of vision.　

In May and June, 2023, Chabaidao successively received two rounds of financing totaling 970 million yuan, which was led by Lanxin Asia, followed by many well-known investment institutions such as Zhengxin Valley, Grassroots Zhiben, CICC and Tomato Capital, with a post-investment valuation of 17.6 billion yuan.　

According to the latest prospectus information of Chabaidao, Wang Hao and Liu Yuhong hold about 81.75% of the shares of Chabaidao. According to the valuation of 18 billion, their net worth has reached about 14.5 billion yuan. Wang Hao and Liu Yuhong also made the Hurun Report in 2023 and became the new "dark horse" in the rich list in 2023.　

02.99% of the revenue depends on franchisees, and the pressure on the supply chain is not small.

Looking back on the development of Tea Hundred Roads, we can see that joining in business is an important driving force for the rapid development of Tea Hundred Roads.　

According to the prospectus, as of December 31st, 2023, Chabaidao has opened 8,016 stores in China, covering 31 provinces and cities across the country, achieving comprehensive coverage of all provinces and county-level cities in China. Among them, the proportion of franchise stores accounted for 99%.　

On the surface, it seems that Chabaidao is a direct consumer-oriented business, but in fact, Chabaidao is similar to Mixue Ice City, and it is also a supply chain company wearing a milk tea coat. Selling goods and equipment to franchisees is the core business of Chabaidao.　

According to the prospectus, from 2021 to 2023, Chabaidao achieved revenues of 3.625 billion yuan, 4.197 billion yuan and 5.659 billion yuan through franchise stores, accounting for more than 99% of the total revenue; Among them, the income from selling goods and equipment to franchise stores accounts for about 95%, and the gross profit margin of this business is also maintained at about 32%.　

△ Chart source: screenshot of Cha Baidao prospectus　

The core of this business model, similar to S2B2C, is to reduce the operating costs of franchisees and improve the overall profitability through the advantages of supply chain and standardized processes.　

However, unlike the self-built supply chain of Mixue Ice City, Chabaidao mainly relies on third-party suppliers and other business partners to provide raw materials and services for it.　

According to the prospectus, in 2023, the procurement ratio of Chabaidao from its top five external suppliers (including dairy products, sugar, juice and other ingredients, packaging materials, etc.) was as high as 36.6%.　

△ Chart source: screenshot of Cha Baidao prospectus　

Perhaps it is also realized that there is no small risk in relying on third-party suppliers. Therefore, in the past several rounds of financing, Cha Baidao has repeatedly mentioned that the funds raised are mainly used to improve the overall operational capability and strengthen the supply chain capability.　

At present, Chabaidao has established a supply chain center covering every key link of supply chain management from product development, procurement, logistics to after-sales service and quality control. At the same time, Sichuan Tea Co., Ltd. was established to provide brand logistics and distribution services.　

In addition, Chabaidao and Bawang Chaji jointly established Sichuan Chabenyuan New Materials Technology Co., Ltd.. The company’s business scope includes research and development of new materials technology, manufacturing of bio-based materials, standardization services, sales and manufacturing of plastic products, sales of packaging materials and products, and import and export of goods.　

It is worth noting that in addition to the continuous strengthening of the supply chain, Chabaidao has been actively exploring overseas markets and coffee tracks in the past two years.　

In December 2023, Chabaidao opened the first store of coffee sub-brand "Coffee Ash" in Chengdu, and entered the coffee track for the first time.　

In January 2024, Chabaidao officially went to sea, and the first overseas store was selected in Gangnam-gu, Seoul, South Korea. Later, stores were opened in Seoul Hongda and Seoul Yau Pavilion. As of April 20, 2024, the number of Chabaidao stores in Korea has reached three.　

At present, it remains to be seen whether Chabaidao has explored the new amount in terms of going to sea and coffee business.　

03. Queue for listing, and the 2024 New Tea Listing Competition started.

In fact, in addition to the hundreds of teas, there are many tea brands waiting in line for listing.　

In January this year, Mi Xue Bing Cheng and Gu Ming submitted prospectuses to the Hong Kong Stock Exchange at the same time. Subsequently, on February 14th, Auntie Shanghai, a tea brand, submitted a prospectus to the Hong Kong Stock Exchange. The co-sponsors were CITIC Securities, haitong international and Dongzheng International.　

△ Image source: Red Meal Network photo　

On April 11th, the Hong Kong Economic Daily also reported that Bawang Tea Ji would go public in the United States as soon as the middle of this year, raising between 200 million and 300 million US dollars (a contract of 1.57 billion to 2.35 billion Hong Kong dollars).　

Why do new tea brands start to get together and go public? In this regard, there are many views in the industry that whoever can take the lead in successful IPO will seize the opportunity among the tea drinks that are "rolled out of the sky".　

In particular, tea brands need a lot of financial support to cope with the competition in the current tea track such as "joining war", "sinking war" and "price war".　

In the past year, in addition to hundreds of teas, brands such as Guming and Auntie in Shanghai have also announced the sprint of 10,000 stores. In order to achieve this goal first, brands often need more funds to spread the store network. With the cooling of the new consumer investment market, the attention of the primary market to the new tea market has obviously declined. Therefore, listing has become a new way for new tea drinkers to obtain funds.　

But the success of listing does not mean that the brand can sit back and relax. Take Chabaidao as an example, it and most new tea brands are in the mid-range price range of 10-20 yuan, including the above-mentioned Guming, Shanghai Auntie and Bawang Tea Ji, which are already waiting in line for listing.　

There are many competitors, and the homogenization of new tea itself has become more and more serious. It is conceivable that these new tea brands in the middle price zone will still face a lot of competitive pressure in the future.